The Clinical Biology of Sodium

1st Edition

The Physiology and Pathophysiology of Sodium in Mammals

Authors: A. R. Michell
Hardcover ISBN: 9780080408422
eBook ISBN: 9781483100821
Imprint: Pergamon
Published Date: 1st January 1995
Page Count: 388
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Description

The Clinical Biology of Sodium: The Physiology and Pathophysiology of Sodium in Mammals presents a comparative view of mammalian sodium regulation and its clinical disturbances. This book covers a wide range of topics, including the physiological basis of fluid therapy, oral rehydration for diarrhea, the pathogenesis of edema, hypovolemia, endocrine regulation and disturbances, and nutritional requirement.

Organized into 12 chapters, this book begins with an overview of the distribution and physiological functions of sodium. This text then explores the two processes that provide the basis of most of the non-endocrine functions of the kidneys, namely, glomerular filtration and tubular reabsorption of sodium. Other chapters consider the avoidable human and material costs of hypertension. This book discusses as well the molecular biology of sodium transport. The final chapter deals with the three mechanisms capable of detecting changes in cardiovascular filling.

This book is a valuable resource for doctors, nurses, and veterinarians.

Table of Contents


Preface


Introduction


1. Body Sodium in Context: Distribution, Functions and Regulation


Introduction: Some Problems in Context


Distribution and Concentration of Sodium


Basic Principles


Simple Disturbances


Oedema


Bone Sodium


Sodium in Brain and Cerebrospinal Fluid


Functions of Sodium


Sodium Transport: Na-K ATPase


Isoforms


Factors Affecting Activity


Na+-H+ Exchange


Conclusion


2. Renal Sodium Regulation


Introduction


Segmental Distribution of Sodium Reabsorption


Effects of Hypovolaemia


Endocrine Aspects of Renal Sodium Regulation


Glomerular Filtration


Ultrafiltration


Proximal Reabsorption


Loop of Henlé


Ascending Thick Limb


Regulation of ADH Release


Distal Nephron


Immaturity of Renal Function


Conclusion


3. Enteric Sodium Uptake


Introduction


Enteric Sodium Transport


Enteric Sodium Regulation


Enteric Responses to Changes in Sodium Balance


Diarrhoea


Oral Rehydration


Principles and Criteria of Efficacy


Amino Acids


Bicarbonate Precursors


Sodium


Sequestration: Third Space'


Iatrogenic Disturbances


Conclusion


4. Behavioural Regulation of Sodium Intake


General Issues


An Assumed Need, or a Real One?


Experimental Approaches


Early Studies of Salt Appetite


Studies in Sodium-Depleted Sheep


1. Neural Aspects


Taste


Details

No. of pages:
388
Language:
English
Copyright:
© Pergamon 1995
Published:
Imprint:
Pergamon
eBook ISBN:
9781483100821
Hardcover ISBN:
9780080408422

About the Author

A. R. Michell