The Choroid Plexus and Cerebrospinal Fluid - 1st Edition - ISBN: 9780128017401, 9780128018422

The Choroid Plexus and Cerebrospinal Fluid

1st Edition

Emerging Roles in CNS Development, Maintenance, and Disease Progression

Editors: Josh Neman Thomas C. Chen
eBook ISBN: 9780128018422
Hardcover ISBN: 9780128017401
Imprint: Academic Press
Published Date: 1st October 2015
Page Count: 210
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The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression combines new and established work to allow for cross-disciplinary discussion and showcase newfound excitement surrounding the choroid plexus and cerebrospinal fluid (CSF). This book is of great utility to neuroscientists interested in biological questions about cancer, multiple sclerosis, Alzheimer’s, choroid plexus, or CSF research, and especially for researchers looking to expand their research into later stages of their disease of interest, such as metastasis. No other resource is currently available which addresses these issues in this fashion. The focus on the choroid plexus provides a practical resource on modeling clinical issues influenced by this brain region for researchers from students to principal investigators.

Key Features

  • Presents recent progress made in the research of choroid plexus and cerebrospinal fluid across multi-disciplinary fields, including neuroscience, cancer biology, and immunology
  • Includes numerous illustrations of light, fluorescent, and electron micrographs
  • Provides data analysis boxes in each chapter to help with data interpretation and offer guidelines on how best to represent results
  • Includes chapters written by prominent researchers in the field


Graduate students in biological and biomedical sciences, post-doctoral students and fellows, as well as all researchers and clinicians seeking a resource on the interactions of choroid plexus, cerebrospinal fluid during normal development, maintenance of brain microenvironment and neurodegenerative diseases (Multiple Sclerosis and Alzheimer’s Disease) and brain tumors (primary and metastatic).

Table of Contents

  • Dedication
  • List of Contributors
  • About the Editors
  • Preface
  • Acknowledgment
  • List of Abbreviations
  • Chapter 1: Introduction to the Ventricular System and Choroid Plexus
    • Abstract
    • Development of the ventricular system
    • Formation of the choroid plexus
    • Cerebrospinal fluid
    • Vascular supply of the choroid plexus
  • Chapter 2: Development of Brain Ventricles and Choroid Plexus
    • Abstract
    • Introduction
    • Neural plate and neural tube formation
    • Ventricular system development
    • Choroid plexus development
  • Chapter 3: Choroid Plexus: Structure and Function
    • Abstract
    • Basic anatomy
    • Inflammatory cells in the choroid plexus
    • Macrophages
    • Dendritic cells
    • T Lymphocytes
    • Cerebrospinal fluid
    • Conclusions
    • Acknowledgment
  • Chapter 4: Toward an Artificial Choroid Plexus, Concept and Clinical Implications
    • Abstract
    • Introduction
    • The CP is the major site for CSF formation, really?
    • CP as a site for secretion of biologically active compounds
    • Pharmacological considerations for the distribution of peptides within the CSF space
    • Toward an artificial choroid plexus
    • Conclusions
  • Chapter 5: Choroid Plexus Tumors
    • Abstract
    • Introduction
    • Primary choroid plexus tumors
    • Secondary choroid plexus tumors
  • Chapter 6: Role of Blood–Brain Barrier, Choroid Plexus, and Cerebral Spinal Fluid in Extravasation and Colonization of Brain Metastases
    • Abstract
    • Brain metastases
    • Blood–brain barrier versus blood–CSF barrier
    • Successful drug delivery through the BBB
  • Chapter 7: The Role of the Choroid Plexus in the Pathogenesis of Multiple Sclerosis
    • Abstract
    • The neural immune system compared with the peripheral immune system
    • The importance of the presence of immune cells in the neural parenchyma
    • The choroid plexus as a possible hot spot for immune cell infiltration
    • Background on multiple sclerosis
    • The relationship between the choroid plexus and multiple sclerosis pathogenesis
    • Physical changes that occur in the choroid plexus as a result of immune cell infiltration
    • Future directions
    • Conclusions
  • Chapter 8: The Choroid Plexus and Cerebrospinal Fluid System: Roles in Neurodegenerative Diseases
    • Abstract
    • Introduction
    • Part 1: Choroid plexus, cerebrospinal fluid, interstitial fluid: relationship with glymphatic system
    • Part 2: Choroid plexus: inflammation and neurodegenerative diseases
    • Part 3: CSF/ISF process in neurodegenerative diseases: pathophysiology and biomarkers
    • Conclusions
    • Acknowledgments
  • Chapter 9: Delivery Considerations for Targeting the Choroid Plexus–Cerebrospinal Fluid Route
    • Abstract
    • Introduction
    • Anatomical considerations
    • Pros and cons of drug delivery via the choroid plexus–CSF barrier
    • Novel methods for CSF delivery and choroid plexus targeting
    • Clinical implications of drug delivery to choroid plexus
    • Conclusions
  • Glossary
  • Subject Index


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About the Editor

Josh Neman

Josh Neman

Dr. Josh Neman completed his doctoral training in neurobiology at UCLA where he studied the development of oligodendrocytes from embryonic stem cells. Dr. Neman then chose to pursue his postdoctoral fellowship at City of Hope, where it would enable him to solidify the bridge between bench to bedside care for cancer patients. His current research investigates the biology of glioblastoma multiforme and breast to brain metastases. Dr. Neman’s expertise and strengths in stem cells, glial biology, neural development, synaptic plasticity, and trauma, have allowed for the development of novel approaches to study the brain and tumor microenvironment ---a vantage point that is currently lacking in the field of brain metastases. His research studies have established that the physiologic microenvironment of the brain must become a tumor-favorable microenvironment for successful metastatic colonization by circulating breast cancer cells. Dr. Neman has more than 30 peer reviewed original research articles (in PNAS, PLoS One, Spine, Neurosurgery, and Developmental Neurobiology), reviews, abstracts, and book chapters to his name. He is currently in process of co-editing the second edition of “Clinical Cases: Neuroscience” which is scheduled to be published in late 2014. Moreover, he has been recipient of research awards from NIH-NCI and California Institute for Regenerative Medicine.

Affiliations and Expertise

Department of Neurological Surgery, Keck School of Medicine, USC, Los Angeles, CA, USA

Thomas C. Chen

Dr. Chen is currently Professor of Neurological Surgery and Pathology at the University of Southern California. Highly experienced in the area of translational research aimed at the development of clinical trials and novel therapeutics for malignant brain tumours, he is the head of the Glioma Research Group at USC. He completed his neurological surgery residency and PhD in pathobiology at the University of Southern California, followed by fellowship training in spinal surgery from the Medical College of Wisconsin. Dr. Chen is a physician, a board certified neurosurgeon, and the Director of Surgical Neuro-oncology – recognized both for his skills as a neurosurgeon and his cutting edge research examining glioma biology.

Affiliations and Expertise

Department of Neurological Surgery, Keck School of Medicine, USC, Los Angeles, CA, USA

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