The Choroid Plexus and Cerebrospinal Fluid

The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression combines new and established work to allow for cross-disciplinary discussion and showcase newfound excitement surrounding the choroid plexus and cerebrospinal fluid (CSF). This book is of great utility to neuroscientists interested in biological questions about cancer, multiple sclerosis, Alzheimer’s, choroid plexus, or CSF research, and especially for researchers looking to expand their research into later stages of their disease of interest, such as metastasis. No other resource is currently available which addresses these issues in this fashion. The focus on the choroid plexus provides a practical resource on modeling clinical issues influenced by this brain region for researchers from students to principal investigators.

• Presents recent progress made in the research of choroid plexus and cerebrospinal fluid across multi-disciplinary fields, including neuroscience, cancer biology, and immunology
• Includes numerous illustrations of light, fluorescent, and electron micrographs
• Provides data analysis boxes in each chapter to help with data interpretation and offer guidelines on how best to represent results
• Includes chapters written by prominent researchers in the field

Graduate students in biological and biomedical sciences, post-doctoral students and fellows, as well as all researchers and clinicians seeking a resource on the interactions of choroid plexus, cerebrospinal fluid during normal development, maintenance of brain microenvironment and neurodegenerative diseases (Multiple Sclerosis and Alzheimer’s Disease) and brain tumors (primary and metastatic).

• Dedication
• List of Contributors
• About the Editors
• Preface
• Acknowledgment
• List of Abbreviations
• Chapter 1: Introduction to the Ventricular System and Choroid Plexus
  • Abstract
  • Development of the ventricular system
  • Formation of the choroid plexus
  • Cerebrospinal fluid
  • Vascular supply of the choroid plexus
• Chapter 2: Development of Brain Ventricles and Choroid Plexus
  • Abstract
  • Introduction
  • Neural plate and neural tube formation
  • Ventricular system development
  • Choroid plexus development
• Chapter 3: Choroid Plexus: Structure and Function
  • Abstract
  • Basic anatomy
  • Inflammatory cells in the choroid plexus
  • Macrophages
  • Dendritic cells
  • T Lymphocytes
  • Cerebrospinal fluid
  • Conclusions
  • Acknowledgment
• Chapter 4: Toward an Artificial Choroid Plexus, Concept and Clinical Implications
  • Abstract
  • Introduction
  • The CP is the major site for CSF formation, really?
  • CP as a site for secretion of biologically active compounds
  • Pharmacological considerations for the distribution of peptides within the CSF space
  • Toward an artificial choroid plexus
  • Conclusions
• Chapter 5: Choroid Plexus Tumors
  • Abstract
  • Introduction
  • Primary choroid plexus tumors
  • Secondary choroid plexus tumors
• Chapter 6: Role of Blood–Brain Barrier, Choroid Plexus, and Cerebral Spinal Fluid in Extravasation and Colonization of Brain Metastases
  • Abstract
  • Brain metastases
  • Blood–brain barrier versus blood–CSF barrier
  • Successful drug delivery through the BBB
• Chapter 7: The Role of the Choroid Plexus in the Pathogenesis of Multiple Sclerosis
  • Abstract
  • The neural immune system compared with the peripheral immune system
  • The importance of the presence of immune cells in the neural parenchyma
  • The choroid plexus as a possible hot spot for immune cell infiltration
  • Background on multiple sclerosis
  • The relationship between the choroid plexus and multiple sclerosis pathogenesis
  • Physical changes that occur in the choroid plexus as a result of immune cell infiltration
  • Future directions
  • Conclusions
• Chapter 8: The Choroid Plexus and Cerebrospinal Fluid System: Roles in Neurodegenerative Diseases
  • Abstract
  • Introduction
  • Part 1: Choroid plexus, cerebrospinal fluid, interstitial fluid: relationship with glymphatic system
  • Part 2: Choroid plexus: inflammation and neurodegenerative diseases
  • Part 3: CSF/ISF process in neurodegenerative diseases: pathophysiology and biomarkers
  • Conclusions
  • Acknowledgments
• Chapter 9: Delivery Considerations for Targeting the Choroid Plexus–Cerebrospinal Fluid Route
  • Abstract
  • Introduction
  • Anatomical considerations
  • Pros and cons of drug delivery via the choroid plexus–CSF barrier
  • Novel methods for CSF delivery and choroid plexus targeting
  • Clinical implications of drug delivery to choroid plexus
  • Conclusions
• Glossary
• Subject Index