The Chlamydomonas Sourcebook

The Chlamydomonas Sourcebook

Volume 3: Cell Motility and Behavior

3rd Edition - October 1, 2022

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  • Editor: Susan Dutcher
  • Hardcover ISBN: 9780128225080

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Description

The Chlamydomonas Sourcebook, Third Edition, Volume Three: Cell Motility and Behavior has been fully revised and updated to include the wealth of new resources for the Chlamydomonas community.  The book presents the latest advances in the area from an international array of expert authors, reflecting significant advancements in our understanding of the role of basal bodies and flagella in human diseases. In addition, employing quantitative proteomics/mass spectroscopy as well as cryo EM tomography and single particle cryo EM has revolutionized our knowledge of the axoneme in terms of the location of proteins and their interactions. Current insights on mitosis and cytokinesis, flagellar assembly and motility, intraflagellar transport, and more will ensure use of this reference as a guide for understanding human diseases of the cilium.

Key Features

  • Includes a table listing the known proteins (with NCBI accession numbers) for each structure discussed, along with the known mutations that affect each structure and process
  • Presents an essential reference of a model species for the study of mechanisms of motility in free living cells
  • Includes methods for Chlamydomonas motility research

Readership

Researchers in plant science who study photosynthesis; crop scientists; fertility researchers; mammalian vision researchers; biochemistry researchers; plant physiologists; plant and molecular biologists and even human disease; University and Medical libraries. The book will also be of extreme value to both postdoctoral and graduate students

Table of Contents

  • Preface

    Introduction to Volume 3

    1. Landmark Contributions of Chlamydomonas to Understanding Cilia

    2. Basal bodies

    3. Transition Zone

    4. Dynein

    5. Axonemal Dynein Preassembly

    6. Ciliary Radial Spokes

    7. Central pair

    8. N-DRC

    9. MIPS

    10. Asymmetries

    11. The Chlamydomonas ciliary membrane and its dynamic properties

    12. Physics and mechanics of ciliary beating

    13. IFT

    14. Length control

    15. Ciliary Disassembly

    16. Deciliation

    17. The Eyespot and Behavioral Light Responses

    18. Ciliary adhesion and cilium-generated signaling during fertilization

    19. Cytoskeleton

Product details

  • No. of pages: 474
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: October 1, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128225080

About the Editor

Susan Dutcher

Susan K. Dutcher is Professor and was Director of the McDonnell Genome Institute at Washington University School of Medicine. Her lab investigates the assembly and function of basal bodies/centrioles and cilia using genetics, biochemistry, microscopy, and computational biology in Chlamydomonas as well as human tissue culture cells. The key questions that they address are how these microtubule-based structures are assembled, how they are regulated with respect to the cell cycle and how they function and influence cellular biology, development, and human health. Stemming from their comparative genomics work in 2004, the discovery of many cilia and centriole-based diseases has illustrated the incredible breath of roles that these organelles play in human health. While no longer Director, she remains as the PI of a grant she obtained to build better human and nonhuman primate references, also bringing in underrepresented minorities as undergraduates to expose them to genomics research during the summer.

Affiliations and Expertise

Professor, McDonnell Genome Institute, Washington University School of Medicine, USA

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