The Cerebellum: From Embryology to Diagnostic Investigations

The Cerebellum: From Embryology to Diagnostic Investigations

Handbook of Clinical Neurology Series

1st Edition - June 8, 2018

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  • Editors: Mario Manto, Thierry Huisman
  • eBook ISBN: 9780444639578
  • Hardcover ISBN: 9780444639561

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The Cerebellum: From Embryology to Diagnostic Investigations, Volume 154 is designed to update the reader on the latest and clinically relevant advances in the study of cerebellar diseases in children and adults. It is organized into sections detailing: (1) Embryology, Anatomy and Function, and (2) Diagnostic investigations: Neuroimaging, and includes content on conventional sequences, diffusion tensor imaging, functional MRI, and connectivity studies. Its companion volume, The Cerebellum: Disorders and Treatment, describes disorders (starting from the fetal cerebellum, to adult cerebellum) encountered during daily practice and therapy (including insights into innovative drug and rehabilitative approaches to treat children and adults with cerebellar disorders).

Key Features

  • Provides an in-depth understanding of the cerebellum and its involvement in a wide variety of diseases
  • Explores the long-term outcome data of pediatric cerebellar diseases and potential problems in adult life for patients with pediatric cerebellar diseases
  • Features chapters co-authored by two experts, combining expertise in both pediatric and adult cerebellar diseases


Basic and clinical researchers in neuroscience; fellows, residents, and practicing clinicians in neurology, pediatric neurology, neuropathology, and movement disorders

Table of Contents

  • Section I. Introduction
    1. Historical view

    Section II. Embryology, Anatomy and Function
    2. Embryology
    3. Principles of organization of the human cerebellum: macro and microanatomy
    4. Functional topography of the human cerebellum
    5. Topography of the cerebellum in relationship to social brain regions and emotions
    6. Physiology of the cerebellum
    7. Cerebellar networks and neuropathology of cerebellar developmental disorders
    8. The neuropathology of the adult cerebellum
    9. Cerebellar motor syndrome from children to the elderly
    10. Cognitive aspects: sequencing, behavior and executive functions
    11. Language and the cerebellum

    Section III. Diagnostic Investigations
    12. Ultrasound and CT of the posterior fossa in neonates
    13. Conventional MRI
    14. Probing the neuroanatomy of the cerebellum using tractography
    15. Nuclear medicine of the cerebellum
    16. Genetics of cerebellar disorders
    17. Laboratory investigations
    18. Neurophysiology of gait
    19. Neuro-ophthalmologic assessment and investigations in children and adults with cerebellar diseases
    20. Scales for the clinical evaluation of cerebellar disorders


Product details

  • No. of pages: 368
  • Language: English
  • Copyright: © Elsevier 2018
  • Published: June 8, 2018
  • Imprint: Elsevier
  • eBook ISBN: 9780444639578
  • Hardcover ISBN: 9780444639561

About the Series Volume Editors

Mario Manto

Mario Manto
Dr. Mario Manto is a Neurologist at the Université Libre de Bruxelles (Belgium) with more than 20 years of experience in clinical neurology, particularly cerebellar ataxia. He is a Professor of Neuroanatomy at the University of Mons (Belgium) and Researcher at the FNRS (Belgium). He has been appointed Head of the Department of Neurology of the Centre Hospitalier Universitaire (CHU) de Charleroi (Belgium). The focus of his career for more than 20 years has been the study of cerebellar disorders, from a clinical and basic science point of view. He published more than 160 peer reviewed scientific articles and 15 book chapters on cerebellar topics and he is the editor of 6 books on cerebellar disorders. He is the Founding Editor and Editor in chief of two scientific journals: The Cerebellum and Cerebellum & Ataxias. He is Deputy Editor of the Journal of Neuroengineering and Rehabilitation and a Member of Faculty 1000. He has received many grants from several foundations including the NIH, European Commission, and the Fonds National de la Recherche Scientifique of Belgium.

Affiliations and Expertise

Professor of Neurology, Free University of Brussels; Professor of Neuroanatomy, University of Mons, Mons, Belgium

Thierry Huisman

Thierry Huisman
Thierry A.G.M. Huisman serves as Chairman of the Department of Imaging and Imaging Science at the Johns Hopkins Bayview Medical Center. In addition he is Director of the Division of Pediatric Radiology and Pediatric Neuroradiology at the Johns Hopkins Hospital in Baltimore and Co-Director of the Neurointensive Care Nursery (NICN), the Johns Hopkins Fetal Program and Center for Translational and Molecular Imaging (CTMI). Dr. Huisman is a Professor of Radiology, Pediatrics, Neurosurgery and Neurology. He graduated cum laude from Medical School at the Erasmus University in Rotterdam, the Netherlands, before completing residencies in Radiology and Pediatrics and fellowships in Pediatric Radiology and Neuroradiology at the University Hospital Zurich, Switzerland. He became Chairman and Radiologist-in-Chief of the Department of Diagnostic Imaging at the University Children’s Hospital Zurich in 2005 before he was recruited to Johns Hopkins in 2007. Dr. Huisman enjoyed a research sabbatical at the Massachusetts General Hospital NMR center between 2000-2002. His primary field of expertise and research focuses on advanced, quantitative, precision imaging in the field of Pediatric Neuroradiology. He has given more than 370 invited lectures, published 310 articles and reviews, 57 book chapters, 5 books, serves on multiple scientific committees of the various radiological societies and has organized multiple national and international meetings in Europe and the USA. He has been the founding member of the Swiss Symposium in Pediatric Neuroradiology. Dr. Huisman is a faculty member of the AIRP course in Washington, DC and course advisor for the IDKD course in Davos, Switzerland. Furthermore he has built several patient and family focused multidisciplinary programs and is actively involved in mentorship programs. He is a reviewer for multiple scientific journals and is an editorial member of 5 journals. He served as president of the American Society of Pediatric Neuroradiology (2014/15) and is an elected fellow of the International Cancer Imaging Society. Finally he is a senior editor of the American Journal of Neuroradiology.

Affiliations and Expertise

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Hospital, Baltimore, MD, USA

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