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The Centrosome - 1st Edition - ISBN: 9780123947703, 9781483273426

The Centrosome

1st Edition

Editor: Vitauts I. Kalnins
eBook ISBN: 9781483273426
Imprint: Academic Press
Published Date: 23rd March 1992
Page Count: 380
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The Centrosome collates in one source the work of scientists actively engaged in studying various aspects of the centrosome, using a wide assortment of experimental approaches, techniques, and model systems. It provides useful background information on the present state of knowledge about the centrosome to researchers and advanced students interested in the organization and behavior of cells.
After presenting an overview of a particular area, the articles summarize work from the authors' own laboratories and include new, unpublished material. Emphasis is on the more dynamic aspects of the subject rather than on detailed descriptions. The contributions range from descriptions of the organization of the centrosome at the molecular level to speculations on how the centrosome may affect the behavior of entire cells.
Experimental studies are complemented by theoretical considerations to provide added insight into the structure and function of this organelle and by speculations on directions which appear most profitable for future studies. Controversial ideas and conflicting hypotheses, which often provide the driving force for new advances, have also been included.

Table of Contents



1 Structure and Functions of Isolated Centrosomes

I. Overview

II. The Isolated Centrosome

III. Future Directions and Prospects


2 Ultrastructure of Centrosome Domains and Identification of Their Protein Components

I. Introduction

II. Glycolytic Enzyme and Creatine Phosphokinase Epitopes at Microtubule Organizing Centers

III. p34cdc2 Present at Centrosome, Kinetochore, and along Kinetochore-to-Pole Microtubules

IV. Electron Spectroscopic Imaging of Centrosomes

V. Summary


3 Function and Formation of Centrioles and Basal Bodies

I. Introduction

II. Speculation about the Function of Centrioles and Basal Bodies

III. Speculation about the Formation of Centrioles and Basal Bodies

IV. Discussion

V. Summary


4 Microtubule and Intermediate Filament Patterns around the Centrosome in Interphase Cells

I. Introduction

II. Centrosome and Microtubules

III. Centrosome and Intermediate Filaments


5 Monoclonal Antibodies to Microtubule-Organizing Center Antigens

I. Introduction

II. Antibody Probes Specific for Centrosomes

III. Monoclonal Antibodies to Microtubule-Organizing Center-Containing Structures

IV. Concluding Remarks


6 Role of Centrin in Spindle Pole Dynamics

I. The Centrosome as the Division Center of the Cell

II. Flagellar Basal Apparatus and Centrosome as Functional, Structural, and Molecular Homologs

III. Striated Flagellar Roots and the Pericentriolar Lattice as Structural and Molecular Homologs

IV. Centrin-Containing Fiber Systems as Calcium-Modulated Contractile Organelles

V. Cell Cycle-Dependent Changes in the Cytoplasmic Organization of Centrin

VI. Centrin as a Component of the Cytomatrix

VII. Speculations on the Function of Centrin during Mitosis

VIII. Conclusions


7 Spindle Pole Body of Saccharomyces cerevisiae: A Model for Genetic Analysis of the Centrosome Cycle

I. Introduction

II. Anatomy of Spindle Pole Body

III. Coordination of Spindle Pole Body Cycle with Cellular Behavior

IV. Genetic Analysis of the Spindle Pole Body Cycle

V. Spindle Pole Body Components

VI. Perspectives


8 The Centrosome in Cell Division and Development of Drosophila

I. Introduction

II. Maternal Contribution to Drosophila Egg

III. Mitosis in Drosophila Embryo

IV. Centrosome Duplication in Syncytial Embryos

V. Organizational Role of Centrosome in Embryonic Development

VI. Centrosome Duplication in Mitotic Mutants

VII. Coordinating Biochemical and Genetic Approaches to Understanding Centrosomal Function


9 Control of Centrosome Inheritance in Echinoderm Development

I. Introduction

II. Centrosome Inheritance in Development

III. Centrosome Inheritance in Sea Urchin Eggs

IV. Centrosome Inheritance in Starfish

V. Origin of Centrosomes in Parthenogenetically Activated Eggs

VI. Concluding Remarks


10 The Lymphocyte Centrosome

I. Introduction

II. The Unactivated Lymphocyte

III. The Centrosome and Lymphocyte Activation

IV. The Centrosome and Effector Functions


11 The Centrosome in Stationary and Migrating Endothelial Cells

I. Introduction

II. Distribution of Centrosomes in Endothelial Cells

III. Microtubules and Polarity of Migrating Cells

IV. Position of Centrosomes in Migrating Cells

V. Changes in Centrosome Position in Aortic Endothelial Cells Induced to Migrate

VI. Significance of the Preferential Orientation of Centrosomes in Endothelial Cells of Aorta and Vena Cava

VII. Effect of Cytochalasin B and Colcemid on Centrosome Reorientation

VIII. Mechanisms for Reorientation of Centrosomes

IX. Polarity and Directional Migration of Cells


12 The Centrosome: Contributions to Cell Form

I. Introduction

II. The Centrosome as an Organizational Template Influencing Cell Form

III. Microtubule Organization in Peripheral Cytoplasm

IV. Positioning the Centrosome

V. Prospective


13 Cell Polarity and Centrosomes

I. Introduction

II. Features of the Centrosome

III. Development and Maintenance of Cell Polarity: Three Case Studies

IV. Epilogue




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© Academic Press 1992
23rd March 1992
Academic Press
eBook ISBN:

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Vitauts I. Kalnins

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