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The Cell Cycle - 1st Edition - ISBN: 9781483227979, 9781483274508

The Cell Cycle

1st Edition

Gene-Enzyme Interactions

Editors: G. M. Padilla G. L. Whitson I. L. Cameron
eBook ISBN: 9781483274508
Imprint: Academic Press
Published Date: 1st January 1969
Page Count: 420
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The Cell Cycle: Gene Enzyme Interactions presents the primary regulatory mechanisms of the cell cycle. This book provides theoretical and methodological discussions concerning cell cycles.

Organized into 17 chapters, this book begins with an overview of cell evolution and thermodynamics. This text then examines the regulation of initiation of chromosome replication, and the coordination between this event and cell division, in Escherichia coli. Other chapters consider the operon model for the control of genetic expression in bacterial cells, which provides an understanding of the regulatory mechanisms of gene function. This book discusses as well the observations and experiments on the timing of events in the cell cycles of some bacteria and attempts to provide explanations in terms of established control systems. The final chapter deals with DNA markers, which serve as a convenient starting point for exploring the general principles of cell cycle markers.

This book is a valuable resource for cell biologists.

Table of Contents

List Of Contributors


1. Thoughts on Cell Evolution and Thermodynamics

I. Introduction

II. Genome Evolution

III. Selection and Thermodynamics


2. Regulation of Chromosome Replication and Cell Division in Escherichia coli

I. Introduction

II. Coordination Between Chromosome Replication and Cell Division

III. Regulation of Chromosome Replication and Cell Division

IV. Cellular Response to Nutritional Alterations

V. Conclusions


3. Temporal Control of Gene Expression in Bacteria

I. Introduction

II. Rate of Induced Enzyme Synthesis in Synchronous Populations

III. Change in Rate of Induced Enzyme Synthesis and Sequential Gene Replication

IV. Synthesis of Enzymes in Synchronous Populations

V. Metabolic Oscillations and the Temporal Control of Enzyme Synthesis

VI. Unstable Enzymes and the Cell Cycle

VII. DNA Replication and the Integration of Cell Growth and Division

VIII. Summary and Conclusions


4. Synchrony and the Formation and Germination of Bacterial Spores

I. Introduction to Germination and Sporulation

II. Analysis of Synchrony During Sporulation

III. Germination Synchrony

IV. Microcycle Sporulation

V. Future Possibilities or Problems Possibly Solvable by a Synchronous System of Sporulation


5. Synthesis of Macromolecules During the Cell Cycle in Yeast

I. Introduction

II. Gene Position and Enzyme Timing

III. Syntheses of Ribosomal and Transfer RNA During the Cell Cycle

IV. The Number of Ribosomal RNA Cistrons in Nuclear DNA of Saccharomyces cerevisiae

V. Synthesis of Mitochondrial DNA During the Cell Cycle of Saccharomyces lactis

VI. Conclusions


6. Investigations During Phases of Synchronous Development and Differentiation in Neurospora crassa

I. Introduction

II. Phasing of the Asexual Cycle—Synchronization

III. Utilization of the Phased Asexual Cycle of Neurospora crassa

IV. Summary and Conclusions


7. Nuclear DNA Replication and Transcription During the Cell Cycle of Physarum

I. Introduction

II. DNA Replication

III. DNA Transcription

IV. Summary and Conclusions


8. Control of Enzyme Synthesis During the Cell Cycle of Chlorella

I. Introduction

II. Mass-Culture Technique for Synchronized Cells

III. Control of Enzyme Synthesis During the Cell Cycle

IV. Isozymes and Subcellular Organelles

V. Enzymatic Control of Biosynthetic Pathways


9. Light-Dependent Formation of Nucleic Acids and Its Relation to the Induction of Synchronous Cell Division in Chlorella

I. Introduction

II. Organism and Growth Conditions

III. Synchronization

IV. Induction of Cell Division

V. Nucleic Acid Formation in Synchronized Chlorella Cultures

VI. Discussion of the Linkage Between Nucleic Acid Formation and Induction of Cell Division


10. Effects of High Pressure on Macromolecular Synthesis in Synchronized Tetrahymena

I. Introduction

II. Effects of Pressure on Division

III. Ribosomal Studies

IV. Proteins Associated with Division

V. Pressure Effects on RNA and Protein Synthesis

VI. Discussion


11. The Role of Microtubules in the Cell Cycle

I. Introduction

II. Function and Distribution of Microtubules

III. Structure of Microtubules

IV. Microtubules in the Cell Cycle

V. Summary


Note Added in Proof

12. Biochemical Aspects of Morphogenesis in the Brine Shrimp, Artemia salina

I. Introduction

II. Nucleotides and Nucleic Acid Metabolism in Encysted Embryos and Nauplii

III. Studies on Protein Synthesis During Preemergence Development

IV. Concluding Remarks: Adaptation and the Development of Encysted Embryos



13. The Program of Structural and Metabolic Changes Following Fertilization of Sea Urchin Eggs

I. Introduction

II. Structural Changes

III. Permeability Changes

IV. Cation and Coenzyme Changes

V. Respiratory Changes

VI. Changes in Synthesis of Macromolecules

VII. The Program of Fertilization Changes—1968

VIII. Interrelationships Between Fertilization Changes

IX. Concluding Remarks


14. Polysomes of Sea Urchins: Retention of Integrity

I. Introduction

II. Organism and Culture Conditions

III. Analytical Tools

IV. Polysome Studies

V. Concluding Remarks


15. Relation of Fine Structure to Biochemical Changes in Developing Sea Urchin Eggs and Zygotes

I. Introduction

II. Nuclear-Cytoplasmic Interaction in Early Sea Urchin Development

III. Characterization of Nucleus-Related Structures

IV. Timing of Developmental Stages and Biochemical Sampling

V. Discussion: A Morphologist's Point of View

VI. Conclusion


16. Essential Biosynthetic Activity in Synchronized Mammalian Cells

I. Introduction

II. Life-Cycle Analysis

III. Conditions Affecting Quality of Cell Synchrony

IV. Timing of Biosynthetic Events

V. Stability of mRNA Associated with Cell Division

VI. Suitability of Synchronized Cells for Marker Characterization

VII. Discussion

VIII. Summary and Conclusions


17. Markers in the Cell Cycle

I. Cycle History

II. Cycle Markers


Author Index

Subject Index


No. of pages:
© Academic Press 1969
1st January 1969
Academic Press
eBook ISBN:

About the Editors

G. M. Padilla

G. L. Whitson

I. L. Cameron

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