The Cell Cycle

The Cell Cycle

Gene-Enzyme Interactions

1st Edition - January 1, 1969

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  • Editors: G. M. Padilla, G. L. Whitson, I. L. Cameron
  • eBook ISBN: 9781483274508

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The Cell Cycle: Gene Enzyme Interactions presents the primary regulatory mechanisms of the cell cycle. This book provides theoretical and methodological discussions concerning cell cycles. Organized into 17 chapters, this book begins with an overview of cell evolution and thermodynamics. This text then examines the regulation of initiation of chromosome replication, and the coordination between this event and cell division, in Escherichia coli. Other chapters consider the operon model for the control of genetic expression in bacterial cells, which provides an understanding of the regulatory mechanisms of gene function. This book discusses as well the observations and experiments on the timing of events in the cell cycles of some bacteria and attempts to provide explanations in terms of established control systems. The final chapter deals with DNA markers, which serve as a convenient starting point for exploring the general principles of cell cycle markers. This book is a valuable resource for cell biologists.

Table of Contents

  • List Of Contributors


    1. Thoughts on Cell Evolution and Thermodynamics

    I. Introduction

    II. Genome Evolution

    III. Selection and Thermodynamics


    2. Regulation of Chromosome Replication and Cell Division in Escherichia coli

    I. Introduction

    II. Coordination Between Chromosome Replication and Cell Division

    III. Regulation of Chromosome Replication and Cell Division

    IV. Cellular Response to Nutritional Alterations

    V. Conclusions


    3. Temporal Control of Gene Expression in Bacteria

    I. Introduction

    II. Rate of Induced Enzyme Synthesis in Synchronous Populations

    III. Change in Rate of Induced Enzyme Synthesis and Sequential Gene Replication

    IV. Synthesis of Enzymes in Synchronous Populations

    V. Metabolic Oscillations and the Temporal Control of Enzyme Synthesis

    VI. Unstable Enzymes and the Cell Cycle

    VII. DNA Replication and the Integration of Cell Growth and Division

    VIII. Summary and Conclusions


    4. Synchrony and the Formation and Germination of Bacterial Spores

    I. Introduction to Germination and Sporulation

    II. Analysis of Synchrony During Sporulation

    III. Germination Synchrony

    IV. Microcycle Sporulation

    V. Future Possibilities or Problems Possibly Solvable by a Synchronous System of Sporulation


    5. Synthesis of Macromolecules During the Cell Cycle in Yeast

    I. Introduction

    II. Gene Position and Enzyme Timing

    III. Syntheses of Ribosomal and Transfer RNA During the Cell Cycle

    IV. The Number of Ribosomal RNA Cistrons in Nuclear DNA of Saccharomyces cerevisiae

    V. Synthesis of Mitochondrial DNA During the Cell Cycle of Saccharomyces lactis

    VI. Conclusions


    6. Investigations During Phases of Synchronous Development and Differentiation in Neurospora crassa

    I. Introduction

    II. Phasing of the Asexual Cycle—Synchronization

    III. Utilization of the Phased Asexual Cycle of Neurospora crassa

    IV. Summary and Conclusions


    7. Nuclear DNA Replication and Transcription During the Cell Cycle of Physarum

    I. Introduction

    II. DNA Replication

    III. DNA Transcription

    IV. Summary and Conclusions


    8. Control of Enzyme Synthesis During the Cell Cycle of Chlorella

    I. Introduction

    II. Mass-Culture Technique for Synchronized Cells

    III. Control of Enzyme Synthesis During the Cell Cycle

    IV. Isozymes and Subcellular Organelles

    V. Enzymatic Control of Biosynthetic Pathways


    9. Light-Dependent Formation of Nucleic Acids and Its Relation to the Induction of Synchronous Cell Division in Chlorella

    I. Introduction

    II. Organism and Growth Conditions

    III. Synchronization

    IV. Induction of Cell Division

    V. Nucleic Acid Formation in Synchronized Chlorella Cultures

    VI. Discussion of the Linkage Between Nucleic Acid Formation and Induction of Cell Division


    10. Effects of High Pressure on Macromolecular Synthesis in Synchronized Tetrahymena

    I. Introduction

    II. Effects of Pressure on Division

    III. Ribosomal Studies

    IV. Proteins Associated with Division

    V. Pressure Effects on RNA and Protein Synthesis

    VI. Discussion


    11. The Role of Microtubules in the Cell Cycle

    I. Introduction

    II. Function and Distribution of Microtubules

    III. Structure of Microtubules

    IV. Microtubules in the Cell Cycle

    V. Summary


    Note Added in Proof

    12. Biochemical Aspects of Morphogenesis in the Brine Shrimp, Artemia salina

    I. Introduction

    II. Nucleotides and Nucleic Acid Metabolism in Encysted Embryos and Nauplii

    III. Studies on Protein Synthesis During Preemergence Development

    IV. Concluding Remarks: Adaptation and the Development of Encysted Embryos



    13. The Program of Structural and Metabolic Changes Following Fertilization of Sea Urchin Eggs

    I. Introduction

    II. Structural Changes

    III. Permeability Changes

    IV. Cation and Coenzyme Changes

    V. Respiratory Changes

    VI. Changes in Synthesis of Macromolecules

    VII. The Program of Fertilization Changes—1968

    VIII. Interrelationships Between Fertilization Changes

    IX. Concluding Remarks


    14. Polysomes of Sea Urchins: Retention of Integrity

    I. Introduction

    II. Organism and Culture Conditions

    III. Analytical Tools

    IV. Polysome Studies

    V. Concluding Remarks


    15. Relation of Fine Structure to Biochemical Changes in Developing Sea Urchin Eggs and Zygotes

    I. Introduction

    II. Nuclear-Cytoplasmic Interaction in Early Sea Urchin Development

    III. Characterization of Nucleus-Related Structures

    IV. Timing of Developmental Stages and Biochemical Sampling

    V. Discussion: A Morphologist's Point of View

    VI. Conclusion


    16. Essential Biosynthetic Activity in Synchronized Mammalian Cells

    I. Introduction

    II. Life-Cycle Analysis

    III. Conditions Affecting Quality of Cell Synchrony

    IV. Timing of Biosynthetic Events

    V. Stability of mRNA Associated with Cell Division

    VI. Suitability of Synchronized Cells for Marker Characterization

    VII. Discussion

    VIII. Summary and Conclusions


    17. Markers in the Cell Cycle

    I. Cycle History

    II. Cycle Markers


    Author Index

    Subject Index

Product details

  • No. of pages: 420
  • Language: English
  • Copyright: © Academic Press 1969
  • Published: January 1, 1969
  • Imprint: Academic Press
  • eBook ISBN: 9781483274508

About the Editors

G. M. Padilla

G. L. Whitson

I. L. Cameron

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