The Cause of Pyloric Stenosis of Infancy

The Cause of Pyloric Stenosis of Infancy

1st Edition - March 10, 2021

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  • Author: Ian Munro Rogers
  • Paperback ISBN: 9780323897761
  • eBook ISBN: 9780323899932

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The Cause of Pyloric Stenosis of Infancy chronicles the debate surrounding the cause of pyloric stenosis from its earliest discovery 300 years ago to the present. The Primary Hyperacidity Theory offers a credible explanation for all the classical signs and symptoms of pyloric stenosis as well a its associated features. In addition, this book comprehensively explores the medical and surgical treatment options as well as the general features used for diagnosis. An understanding of the true cause of pyloric stenosis will thus allow for treatment that is more individualized and sensitive to patients’ needs.

Key Features

  • Catalogues the classical signs and symptoms of pyloric stenosis and relates to their proposed causes
  • Investigates previously unexplained time-sensitive symptoms by relating them to a delay in maturation of the negative feedback between gastrin and acidity
  • Solves the mysteries of first-born preponderance, male predominance, and familiar inheritance
  • Includes stories from real life families dealing with pyloric stenosis to supplement science


Pediatric researchers, pediatric surgeons, pediatricians. Medical students

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Foreword
  • Acknowledgments
  • Introduction
  • The first boy
  • Preamble
  • Chapter 1: The early descriptions
  • Abstract
  • Overview
  • The 1911 M.D. Thesis
  • Early adjuvant diagnostic procedures
  • Chapter 2: The early theories of causation
  • Abstract
  • Were the retained stomach contents different in any way?
  • Chapter 3: History of medical treatment
  • Abstract
  • Medical treatment
  • Antispasmodic drugs
  • Dietary measures used to treat PS
  • Other methods
  • Chapter 4: Early surgical treatment
  • Abstract
  • Preliminary jejeunostomy
  • Gastro-enterostomy (GE)
  • Divulsion of the pylorus (Nicoll-Loreta’s operation)
  • Pylorectomy
  • Pyloroplasty (Heineke-Miculicz)
  • Pyloroplasty leaving the mucosa intact (extra-mucosal)
  • Dr. Pierre Fredet
  • Chapter 5: Ramstedt and beyond
  • Abstract
  • The UK experience
  • Chapter 6: The alkalosis story
  • Abstract
  • Histamine, histamine receptors and H2 receptor blockade
  • Alkalosis in PS and the search for the cause
  • A moment in time
  • Chapter 7: The personal story
  • Abstract
  • How it was—Acid secretion physiology
  • Where does pyloric stenosis of infancy come in?
  • The helicobacter story and duodenal ulcer
  • Chapter 8: What makes the adult pyloric sphincter contract?
  • Abstract
  • The contribution from nerves
  • An overview
  • Chapter 9: How does acid in the duodenum trigger sphincter contraction?
  • Abstract
  • Acid sensing-dependent processes in the gastrointestinal tract
  • Overview
  • Chapter 10: Stomach motility and gastric emptying
  • Abstract
  • Motility of the adult stomach
  • Function of the gastric reservoir
  • Gastric emptying and the antral pump
  • Gastric emptying
  • Regulation elicited from stomach
  • Regulation elicited from small intestine
  • Interdigestive motility of stomach and small intestine
  • Chapter 11: The pyloric sphincter and pyloric stenosis of infancy
  • Abstract
  • Chapter 12: Symptoms, signs and other clues
  • Abstract
  • The clinical clues
  • The journey
  • Chapter 13: Genetics—The seed and the soil
  • Abstract
  • Chapter 14: The gastrin connection—Is it responsible for neonatal hyperacidity?
  • Abstract
  • Chapter 15: The hesitant beginnings of the primary hyperacidity theory of cause
  • Abstract
  • The gastrin effect
  • Is a narrowed pylorus enough to kick-start PS in real life?
  • Do babies with PS have high gastrin levels?
  • The sphincter and the agents which cause it to contract
  • The feeding effect
  • Feeding frequency and the effect
  • Chapter 16: The primary hyperacidity theory
  • Abstract
  • PS and acid secretion
  • Physiology of acid secretion
  • The continuum theory
  • Erythromycin
  • The motilin story
  • Chapter 17: Clinical aspects and their explanation
  • Abstract
  • The clinical diagnosis
  • Clinical questions resolved
  • What makes some babies develop PS?
  • Supporting evidence for hyperacidity as the cause
  • Why male babies?
  • Why self-cure with time?
  • Overview
  • Why is it more frequent in the first-born?
  • Medical treatment
  • Two illustrative cases
  • Why does the tumor disappear after pyloromyotomy and not after gastro-enterostomy?
  • Why do symptoms appear at around 3–4 weeks of age?
  • Chapter 18: The link between pyloric stenosis of infancy and duodenal ulcer in adults: Feedback—negative and positive
  • Abstract
  • Pyloric sphincter contraction
  • Hyperacidity and hypertrophy—The connection
  • The acid-producing consequences of pyloric sphincter hold-up
  • The link between pyloric stenosis of infancy and duodenal ulcer in adults
  • The differences between duodenal ulcer and P.S.
  • Conclusion
  • Chapter 19: Other contemporary lines of enquiry
  • Abstract
  • The genetic story
  • Growth factors, chemical agents, and abnormalities of nerves
  • The infection theories
  • Chapter 20: Conclusion
  • Abstract
  • Chapter 21: The PS or reflux dilemma: Addendum 1
  • Abstract
  • Milk vomiting or regurgitation in the first 3 months of life
  • Conclusion
  • Chapter 22: The real world: Addendum 2
  • Index

Product details

  • No. of pages: 170
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: March 10, 2021
  • Imprint: Academic Press
  • Paperback ISBN: 9780323897761
  • eBook ISBN: 9780323899932

About the Author

Ian Munro Rogers

Ian Munro Rogers worked as a Consultant Surgeon at the Ingham Infirmary, South Shields and subsequently at South Tyneside Foundation Trust, from 1978 to 2004. He went to Allan Glen’s School, Glasgow and earned an M.B., Ch.B. from Glasgow University in 1967. Dr. Rogers received surgical training at Glasgow Royal Infirmary and Westminster Hospital London. He is the author of many papers on the cause of pyloric stenosis of infancy and other general surgical topics. Dr. Rogers was President of the North East Surgical Society of England in 2000 and, for many years, he was also a Guest Examiner in Surgery for the Royal College of Physicians and Surgeons, Glasgow. After retirement, he spent several years teaching surgery at AIMST University in Malaysia as a Visiting Professor in Surgery. Now retired, Dr. Rogers spends most of his time pursuing his hobby of music as a choir Member (Voices Together) as well as a singer in a musical trio (The Three Wise Men). He is married with 4 children

Affiliations and Expertise

Retired Consultant Surgeon, South Tyneside Hospital; Prof. Surgery AIMST University, Malaysia

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  • Dr. O. Wed Oct 26 2022

    Wonderful clear exposition of the

    Wonderful clear exposition of the true cause.. Historical challanges and background to the theory simply and fully covered. A clear pathway is indicated to a different emphasis and and a more baby-sensitive form of treatment. Should be read by every doctor dealing with the neonate.