The Business of Precision Medicine - 1st Edition - ISBN: 9780128153246

The Business of Precision Medicine

1st Edition

How to Create and Develop a Sustainable and Scalable Business in Precision Medicine

Authors: Manuel Corpas
Paperback ISBN: 9780128153246
Imprint: Academic Press
Published Date: 1st July 2019
Page Count: 200
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Description

In a short period of time, precision medicine has grown from a new medical science to an implementable set of clinical methods and technologies whose concrete applications are revolutionizing the healthcare sector.

With The Business of Precision Medicine, Dr. Manuel Corpas bridges knowledge gaps and brings true business advantage to those seeking to harness fresh opportunities in todays’ global precision medicine landscape. Beginning with a basic overview of the precision medicine paradigm shift, this book provides in-depth case studies of companies, start-ups, and institutions of various kinds in the public and private sectors, demonstrating how they successfully adopted new genomic technologies and databases—including bioinformatics tools, genetic signatures, and gene panels—to build robust and scalable businesses. Dr. Corpas offers sound, evidence-driven approaches to incorporate genomic data discovery and access, DNA testing & diagnosis, direct to consumer genetic testing, genomics in individual health planning, biomarker development, companion diagnostics, and conducting clinical trials into your commercial strategy.

With robust case studies and thoughtful business frameworks, The Business of Precision Medicine supports a diverse community of industry professionals, clinicians, and entrepreneurs driving the evolution of Precision Medicine. Those already working in and those who would like to enter precision medtech, biopharma, and healthcare, as well as life science industry representatives from pharmaceutical and diagnostic industries, will discover an invaluable guide in this practical text.

Key Features

  • Plan a business strategy that considers the impact of future research and clinical implementation of precision medicine
  • Successfully navigate the regulatory environment that frames technology application in precision medicine
  • Adopt fast-evolving ’data landscapes’ and big data innovation frameworks in your business strategy
  • Harness a variety of viable commercial models around bio banking, bioinformatics, and genomic analysis for stratified medicine

Readership

Business executives; scientist-entrepreneurs; students; physicians, and researchers in the field of medical genetics, precision medicine, business, and entrepreneurship; clinical innovators; hospital executives; health policy makers; patient advocates; entrepreneurs; angel and venture capital investors; medical practitioners across medical disciplines as well as systems biology, molecular medicine, and genetic epidemiology; genetic counselors; human geneticists in industry and pharma

Table of Contents

1. Introduction to Precision Medicine
2. Ethical and Practical Challenges in Precision Medicine
o Limitations
o Ethical challenges
o Data Issues
o Case study: prenatal diagnosis
3. Clinical Genomics
o Progress in sequencing technologies
o Application to diagnostics
o Case study: the DECIPHER database & the Deciphering Developmental Diseases project
4. The Role of Genomic Data in Precision Medicine
o Genomic data generation
o Big Data Challenges
o Products and services
o Case study: Genomics England
5. Challenges in Data Discovery and Access
o The Population-Scale National Genome Project Race
o Data repositories
o Access governance models
o Case study: Repositive
6. The Business of DNA Testing & Diagnosis
o Business models
o Direct to consumer genetic testing
o Case study 23andMe
o Genomics as part of individual health planning
o Open vs. close access
o Case study: Veritas Genetics vs. Human Longevity
7. Development of biomarkers
o Global markets for biomarkers
o Biomarkers for Precision Medicine
o Companion Diagnostics
o Use case: Inivata (Liquid biopsies)
8. Clinical trials
o Precision Medicine Clinical Trial Case Study
9. Implementation – build a strategy for adopting a precision medicine approach

Details

No. of pages:
200
Language:
English
Copyright:
© Academic Press 2019
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128153246

About the Author

Manuel Corpas

Dr. Manuel Corpas is Scientific Lead at Repositive, a Cambridge, UK start-up company focusing on efficient human genomic data discovery, access, and sharing. He is also a 2016 Fellow of the Software Sustainability Institute and sits on the Board of Directors of the International Society for Computational Biology. Previously Dr. Corpas was Technical Coordinator of the Horizon 2020 Research Infrastructure ELIXIR-UK, Coordinator of the BioJS open source community, and Chair of the Technical Committee for the Global Organisation for Bioinformatics Learning, Education and Training (GOBLET). Dr. Corpas received a M.Sc. in Bioinformatics from the University of Manchester, UK, and a B.Sc. in Biology from the University of Navarra, Spain. He holds a Ph.D. in Computer Science from the University of Manchester, and completed post-doctoral work in clinical genomics at the Wellcome Trust Sanger Institute, Cambridge, developing the DECIPHER database. Dr. Corpas has taught several 3 day Master Classes and podcasts in Precision Medicine in the US, UK, and Europe, covering precision medicine fundamentals, ethics, and business and entrepreneurial aspects.

Affiliations and Expertise

Scientific Lead, Repositive, Cambridge, UK

Ratings and Reviews