The Biochemistry of Poliomyelitis Viruses - 1st Edition - ISBN: 9780080101118, 9781483150338

The Biochemistry of Poliomyelitis Viruses

1st Edition

A Synopsis of Poliomyelitis Infection and Research

Authors: Ernest Kovács
Editors: P. Alexander Z. M. Bacq
eBook ISBN: 9781483150338
Imprint: Pergamon
Published Date: 1st January 1964
Page Count: 284
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The Biochemistry of Poliomyelitis Viruses deals with the interrelationships and differences of positions in the field of poliomyelitis research.
This volume presents a general introduction to viruses as to their descriptions and biological, biochemical, and epidemiological aspects. Clinical poliomyelitis, test measurements in the cerebrospinal fluid, and the actions of the poliomyelitis virus are explained. The isolation of the poliomyelitis virus and some aspects of its immunology and serology through refinements of serologic tools and special techniques, plus the state of poliovirus purification, are noted. This book also gives assumptions about the virus' synthetic activities in vivo based on experiments conducted in other viral diseases other than the polio virus. This text also notes that important discoveries such as those made by Gierer and Schramm or Fraenkel-Conrat provide updated poliomyelitis research. Other research studies are taken into consideration and emphasis is given to the biochemical concept of the polio infection and the related features induced during infection such as the presence of tumors. The most promising trend in research is in the study of enzymes of infected cells leading to an understanding of the biochemistry of viral diseases. The use of inference microscopy and X-ray analysis of cell mass is recommended.
This book will prove invaluable for microbiologists, disease investigators, clinical workers, and research scientists.

Table of Contents



Chapter 1. The Viruses (A General Introduction)

A. Virus in Older Definitions

B. Virus as it Looks Now

References to Chapter 1

Chapter 2. The Biological, Biochemical and Epidemiological Aspects of Poliomyelitis of Man and Animals

The Human Disease

1. General Notions

2. Clinical Poliomyelitis

3 . Biochemical Aspects

References to Chapter 2

Chapter 3. Experimental Poliomyelitis

1. The Disease in Animals

2. Isolation of the Poliomyelitis Virus and Its Bioassay

Virus Identification and Titration on Experimental Animal

The Use of Cells in Culture for Identification of the Poliomyelitis Viruses

Some Aspects of the Immunology and Aerology of Poliovirus

References to Chapter 3

Chapter 4. Biochemical Data on Poliovirus

Purification, Crystallization, Biochemical and Biophysical Characterization of Poliomyelitis Viruses

Preparation of Crystalline and Radioactive Poliovirus

Physical and Chemical Parameters of Purified Poliovirus

Additional Biological, Biochemical and Biophysical Characteristics of Poliovirus

Effect of Electronic and/or Ionizing Radiation

Specific Infectivity and the Infectious Unit

Virus Nucleic Acid and Infectivity

Resistance of Poliovirus to Cytolytic Agents and Enzymes

Resistance of Poliovirus to some Physical Factors

Effect of Chemical Agents and Disinfectants

References to Chapter 4

Chapter 5. Biochemistry of Animal-Adapted Poliomyelitis Infection, In Vivo


Respiration and Glycolysis

Phosphate Metabolism and Change in the Activity of Oxidative Enzymes

Biochemical Data of Chromatolytic Neurons and Virus Infected Tissues

Further Intracellular Localization of Virus Growth

The Role of Nutrition and Co-factors

The Application of Enzyme Inhibitors

Environmental Conditions and Conditional Factors

Effect of Hormones

Data on the Effect of X-Ray Radiation, Physical and Chemical Agents

References to Chapter 5

Chapter 6. Further Considerations of the General Biology, Biochemistry and Pathology of Experimental Poliomyelitis Infection in Animals

1. Nucleic Acid of the Host and the Virus during Experimental Poliomyelitis, In Vivo

2. Complementary Data on the Biology of Animal Infection

References to Chapter 6

Chapter 7. The Host Cells in General

1. General Properties of the Cells in Culture In Vitro

2. Light Microscopic Cytopathic Changes due to the Poliovirus Infection

3. Some Facts on the Cellular Organization as Revealed by Utrastructural Research

References to Chapter 7

Chapter 8. Some Cytological and Biological Effects of Poliomyelitis Virus on Cells in Culture

1. General Notions

2. Changes in Cell Morphology

3. General Biological Observations and Use of Special Techniques

References to Chapter 8

Chapter 9. Biochemistry of Poliovirus Infection in Cells in Culture

General Notions, Respiration and Glycolysis

Effect of Nutrition and Environmental Temperature

Work with Radioactive Tracers

Quantitative Nucleic Acid Changes

Recent Findings Regarding the Biosynthesis of the Protein and Nucleic Acid of Poliovirus

Some Biochemical Data of Latent Infection

References to Chapter 9

Chapter 10. Change in the Physiology of Cells during Poliovirus Infection, In Vitro

1. Further Data on Biochemical and Especially Enzyme Changes in the Host Cells

2. Early Irreversible Enzyme Alterations Leading to the Destruction of the Host

3 . The Influence of Hormones and Other Biological Agents Administered In Vitro

References to Chapter 10

Chapter 11. The Role of Heredity

1. Genetic Aspects of Clinical and Experimental Poliomyelitis

2. Virus Genetics

3 . Hypotheses on the Biochemical Mechanism of Heredity

References to Chapter 11

Chapter 12. Further Considerations on the Epidemiology and Immunology of Poliomyelitis Infection

1. General Notions

2. The Question of Immunity against Poliomyelitis

3. Defense Against Poliomyelitis and the Efforts for the Prevention of the Disease

References to Chapter 12

Chapter 13. Facts and Speculations on the Biosynthesis of the Poliovirus, a Working Hypothesis of the Author

References to Chapter 13

Chapter 14. Chemical, Physical and Biological Foundation of Virus Research

1. Essential Notions of Nucleic Acid and Protein Biochemistry

Physical and Chemical Properties and Structure of Polynucleotides

Structure, Enzymic Degradation and Synthesis of RNA and DNA

2. Chemical Structure and Biochemistry of Proteins

Proteolytic Enzymes

3. Biosynthesis of the Proteins and Nucleic Acids

Uptake of the Aminoacids into the Cells

Synthesis of Proteins in Subcellular Components

The pH-5 Enzyme and Aminoacid Activation

Essential Aspects of the Biosynthesis of Nucleic Acids

Enzymatic Synthesis of Polynucleotides

4. Nucleic Acid Synthesis in Animal Systems

References to Chapter 14

Chapter 15. The Biochemical Concept of Poliomyelitis Virus Infection

References to Chapter 15

Chapter 16. Biochemical Aspects of Some Other Features of the Virus Problem

Virology and Tumors

References to Chapter 16

Chapter 17. Recent Developments in Poliomyelitis Research

References to Chapter 17

Chapter 18. Discussion and Conclusions

Author Index

Subject Index

Other Titles in this Series


No. of pages:
© Pergamon 1964
eBook ISBN:

About the Author

Ernest Kovács

About the Editor

P. Alexander

Z. M. Bacq