The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle - 1st Edition - ISBN: 9780128164303, 9780128167427

The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle

1st Edition

Editors: Eric Murillo-Rodriguez
Hardcover ISBN: 9780128164303
eBook ISBN: 9780128167427
Imprint: Academic Press
Published Date: 27th March 2019
Page Count: 220
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The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle provides the first comprehensive overview on the molecular methodologies used to evaluate sleep while also examining the cellular, biochemical, genetic, and therapeutic aspects of the sleep-wake cycle. There have been profound changes in the landscape of approaches to the study of sleep – mainly in the areas of molecular biology and molecular techniques. With this great focus on using multidisciplinary molecular methods, chapters address significant advances in the molecular mechanisms underlying sleep and the techniques researchers use to study this phenomenon.

Written by world-leading experts in the area, this book is of great interest to researchers working in the sleep field and to anyone interested in one of the most mysterious phenomena in science – why we sleep and why we cannot survive without it.

Key Features

  • Reviews the neurobiological and cellular mechanisms of the sleep-wake cycle
  • Provides the implications of sleep in health and disease
  • Contrasts different techniques to study molecular mechanisms
  • Contains case studies to better illustrate points
  • Covers sleep disturbance and health problems involved in sleep
  • Includes chapters on the ontogeny of sleep, along with multiple mechanisms for sleep generation


Neuroscientists, graduate and undergraduate students in biological and biomedical sciences, post-doctoral fellows, researchers

Table of Contents

Ritchie E. Brown, VA Boston Healthcare System and Harvard Medical School, Boston, MA. USA
1. The Sleep-Wake Cycle. An Overview
Timothy A Roehrs, Sleep Disorders and Research Center of Henry Ford Health System, Detroit, MI. USA
2. Multiple experimental approaches for studying the sleep-wake cycle
Carlos Blanco-Centurión, The Medical University of South Carolina, USA
3. Phylogeny of Sleep
Patrick McNamara, VA New England Healthcare System and Boston University, Boston, MA. USA
4. Neuromolecular Mechanism for Sleep Generation
Miguel Garzón, Universidad Autonoma de Madrid. Madrid, Spain
5. Physiological Mechanism for Control of Waking
Edgar Garcia-Rill, University of Arkansas for Medical Sciences. Little Rock, AR. USA
6. Pharmacology of Sleep
Pablo Torterolo, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
7. Electrophysiological correlates of the sleep-wake cycle
Subimal Datta, University of Tennessee. Knoxville, TN. USA
8. Sleep Disturbances
Seithikurippu R. Pandi-Perumal, Somnogen Canada Inc. Toronto, ON. Canada
9. Obesity and sleep disturbances
Edward O. Bixler, Penn State University College of Medicine. Hershey, PA.USA
10. Alcoholism and sleep
Mahesh M. Thakkar, University of Missouri. Columbia, MI. USA


No. of pages:
© Academic Press 2019
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editor

Eric Murillo-Rodriguez

Dr. Murillo-Rodríguez is a psychologist and PhD in Biomedical Sciences, both degrees obtained at the National Autonomous University of Mexico (UNAM). He completed his post-doctoral training at Harvard Medical School. He serves as editor in scientific journals such as The International Journal of Neuropsychopharmacology, PLoS ONE, among others. He has published over 50 articles published in peer-review journals, 10 chapters in books and numerous presentations in domestic and international scientific meetings. He is a member of several scientific societies, including the Society for Neuroscience (USA). He has received academic awards such as the Young Investigator Award from the World Federation of Sleep Research and Sleep Research Societies Society, and am member of the National System of Researchers (Level 1) of National Council of Science and Technology (México). His scientific interest lies in the study of the neurobiological mechanisms of the endocannabinoid system on modulating the sleep-wake cycle.

Affiliations and Expertise

Universidad Anáhuac Mayab, Mexico

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