The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle

The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle

1st Edition - March 26, 2019

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  • Editor: Eric Murillo-Rodriguez
  • eBook ISBN: 9780128167427
  • Hardcover ISBN: 9780128164303

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The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle provides the first comprehensive overview on the molecular methodologies used to evaluate sleep while also examining the cellular, biochemical, genetic, and therapeutic aspects of the sleep-wake cycle. There have been profound changes in the landscape of approaches to the study of sleep – mainly in the areas of molecular biology and molecular techniques. With this great focus on using multidisciplinary molecular methods, chapters address significant advances in the molecular mechanisms underlying sleep and the techniques researchers use to study this phenomenon. Written by world-leading experts in the area, this book is of great interest to researchers working in the sleep field and to anyone interested in one of the most mysterious phenomena in science – why we sleep and why we cannot survive without it.

Key Features

  • Reviews the neurobiological and cellular mechanisms of the sleep-wake cycle
  • Provides the implications of sleep in health and disease
  • Contrasts different techniques to study molecular mechanisms
  • Contains case studies to better illustrate points
  • Covers sleep disturbance and health problems involved in sleep
  • Includes chapters on the ontogeny of sleep, along with multiple mechanisms for sleep generation


Neuroscientists, graduate and undergraduate students in biological and biomedical sciences, post-doctoral fellows, researchers

Table of Contents

  • Preface
    Ritchie E. Brown, VA Boston Healthcare System and Harvard Medical School, Boston, MA. USA
    1. The Sleep-Wake Cycle. An Overview
    Timothy A Roehrs, Sleep Disorders and Research Center of Henry Ford Health System, Detroit, MI. USA
    2. Multiple experimental approaches for studying the sleep-wake cycle
    Carlos Blanco-Centurión, The Medical University of South Carolina, USA
    3. Phylogeny of Sleep
    Patrick McNamara, VA New England Healthcare System and Boston University, Boston, MA. USA
    4. Neuromolecular Mechanism for Sleep Generation
    Miguel Garzón, Universidad Autonoma de Madrid. Madrid, Spain
    5. Physiological Mechanism for Control of Waking
    Edgar Garcia-Rill, University of Arkansas for Medical Sciences. Little Rock, AR. USA
    6. Pharmacology of Sleep
    Pablo Torterolo, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay
    7. Electrophysiological correlates of the sleep-wake cycle
    Subimal Datta, University of Tennessee. Knoxville, TN. USA
    8. Sleep Disturbances
    Seithikurippu R. Pandi-Perumal, Somnogen Canada Inc. Toronto, ON. Canada
    9. Obesity and sleep disturbances
    Edward O. Bixler, Penn State University College of Medicine. Hershey, PA.USA
    10. Alcoholism and sleep
    Mahesh M. Thakkar, University of Missouri. Columbia, MI. USA

Product details

  • No. of pages: 220
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: March 26, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128167427
  • Hardcover ISBN: 9780128164303

About the Editor

Eric Murillo-Rodriguez

Dr. Murillo-Rodríguez is a Psychologist and PhD in Biomedical Sciences, having completed his post-doctoral training at Harvard Medical School. He has served as editor of multiple journals such as The International Journal of Neuropsychopharmacology and PLoS ONE, among many others. He is a member of several scientific societies, including the Society for Neuroscience. He has received academic awards such as the Young Investigator Award from the World Federation of Sleep Research and Sleep Research Societies Society, and is a member of the National System of Researchers (Level 2) of the National Council of Science and Technology (México). He is also the author of The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy (Elsevier, May 2017).

Affiliations and Expertise

Psychologist, Universidad Anáhuac Mayab, Mexico

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