Description

This book contains a collection of papers on the molecular biology of the band 3 proteins and their various functions: as anion transporters, binding proteins for membrane skeleton, hemoglobin and glycolytic enzymes, and as a recognition signal for the removal of senescent cells by the immuno-system of the body. The papers presented were written to provide an overview of the work carried out during the past five years in most of the laboratories engaged in research on band 3. They serve to give the reader factual information on nearly all aspects of band 3 research, to introduce him to the current literature and to give him a feeling for the philosophy behind the approaches chosen in the various laboratories.

Table of Contents

I. Molecular Biology of Band 3 1. Molecular and cell biological aspects of the AE anion exchanger gene family (S.L. Alper). 2. Structure, molecular genetics and topology of the human red cell anion transporter (AE1) (M.J.A. Tanner, et al.). II. Kinetics 3. Kinetics of anion transport across the red cell membrane (J. Brahm, et al.). 4. Mechanisms of substrate binding, inhibitor binding and ion translocation in band 3 and band 3 related proteins (P.A. Knauf, et al.). 5. Pressure dependence of anion transport in erythrocytes (V.A. Canfield, R.I. Macey). 6. Molecular probing of a hydrophilic/hydophobic interface in the transport domain of the anion exchange protein (AEP) (Z.I. Cabantchik, et al.). 7. Anion binding site in band 3 protein (L. Zaki). 8. Protein chemistry of the anion transport center of erythrocyte band 3. (N. Hamasaki, et al.). 9. Chemical labeling of a glutamate residue involved in proton-sulfate cotransport catalyzed by band 3 (M.L. Jennings). 10. Exploration of the mechanism of mouse erythroid band 3-mediated anion exchange by site-directed mutagenesis (H. Passow, et al.). 11. Evidence for a high and a low affinity C1-/HCO3- exchange system in human red cells (G.F. Fuhrmann, et al.). III. NMR and Spin Label Studies 12. Rates of anion transfer across erythrocyte membranes measured with NMR spectroscopy (P.W. Kuchel, et al.). 13. Spin labeling of band 3, the anion transport protein of the erythrocyte membrane (K.F. Schnell, et al.).14. Studies of band 3 function using substrate analogs: substrate specificity, thermodynamics, and anion binding (R. Labotka, et al.). IV. Electical Properties of Band 3 and the Red Cell Membrane 15. Potential dependence of mouse band 3-mediated anion exchange in Xenopus oocytes. (W. Schwarz, et al.). 16. Oscillating electric fields as possible probes for studying fast ion exchange (E. Donath, M. Egger). 17. Estimates of the Electrical C

Details

No. of pages:
374
Language:
English
Copyright:
© 1992
Published:
Imprint:
Elsevier Science
Electronic ISBN:
9780444599834
Print ISBN:
9780444895479

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