The Autoimmune Diseases

The Autoimmune Diseases

6th Edition - October 15, 2019
This is the Latest Edition
  • Editors: Noel Rose, Ian Mackay
  • Hardcover ISBN: 9780128121023
  • eBook ISBN: 9780128122426

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The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment.

Key Features

  • Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy
  • Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases
  • Keeps readers abreast of current trends and emerging areas in the field
  • Ensures that content is not only up-to-date, but applicable and relevant
  • Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy


Basic and clinical scientists working in immunology, rheumatology and autoimmune diseases

Table of Contents

  • Section 1: Immunologic Basis of Autoimmunity
    1. Prelude: Historical introduction to autoimmunity and autoimmune disease
    2. Structural and Functional Aspects of the Innate and Adaptive Systems of Immunity
    3. General Features of Autoimmune Diseases
    4. Antigen Presentation, Dendritic Cells, and Autoimmunity
    5. T cells and their subsets
    6. Role of Th1 Th2 Th17 Cells in Autoimmunity
    7. Tolerance and Autoimmunity: T Cells
    8. Regulatory T Cells
    9. B Cells and Autoimmunity
    10. Immunological memory T cells
    11. Immunological memory B cells 12. Apoptotic Cells as a Source of Autoantigens
    13. Effector Mechanisms of Autoimmunity: Antibodies and Immune Complexes
    14. Functional Effects of Autoantibodies
    15. Cytokine Chemokines
    16. Signaling Pathways in T and B Lymphocytes
    17. HLA Genetics and Autoimmunity
    18. Non HLA Genetics
    19. AIRE related Autoimmunity
    20. Immune Deficiencies and Autoimmunity
    21. Infections and Autoimmunity
    22. Noninfectious Environmental Agents and Autoimmunity
    23. Sex, Pregnancy and Autoimmunity
    24. Animal Models of Autoimmune Disease

    Section 2: Multisystem Diseases
    25. Systemic Lupus Erythematosus
    26. Systemic Sclerosis, Scleroderma
    27. Antiphospholipid Syndrome
    28. Sjogren Syndrome
    29. Rheumatoid Arthritis
    30. Spondyloarthritis and Chronic Idiopathic Arthropathies
    31. Myositis
    32. Thyroid Disease
    33. Type 1 Diabetes
    34. Adrenalitis
    35. Polyendocrine Syndromes
    36. Gastritis and Pernicious Anemia
    37. Hypophysitis
    38. Hemolytic Anemia
    39. Thrombocytopenic Purpura
    40. Neutropenia
    41. Aplastic Anemia
    42. Clotting Disorders
    43. Multiple Sclerosis
    44. Peripheral Neuropathy
    45. Myasthenia Gravis
    46. Ocular Disease
    47. Inner Ear Disease
    48. Celiac Disease
    49. Inflammatory Bowel Diseases: Ulcerative Colitis and Crohn’s Disease
    50. Chronic Hepatitis
    51. Primary Billiary Cirrhosis
    52. Primary Sclerosing Cholangitis
    53. Pancreatitis
    54. Bullous Skin Diseases: Pemphigus and Pemphigoid
    55. Non-Bullous Skin Diseases: Alopecia, Vitiligo, Psoriasis and Urticaria
    56. Kidney Disease: Goodpasture’s Disease, Lupus Nephritis, ANCA-Associated Glomerulonephritis
    57. Orchitis and Male Infertility
    58. Oophoritis
    59. Rheumatic Heart Disease
    60. Myocarditis and Dilated Cardiomyopathy
    61. Necrotizing Arteritis and Small Vessel Vasculitis
    62. Large and Medium Vessel Vasculitides
    63. Autoimmune Disorders of the Lung
    64. Paraneoplastic Diseases
    65. Antibody-Associated Neurological Diseases
    66. Autoinflammatory and other Related Diseases

    Section 3: Diagnosis, Prevention, and Therapy
    67. Autoantibody Assays, Testing, and Standardization
    68. Prediction of Autoimmune Disease
    69. Emerging Therapies for Autoimmune Diseases
    70. Postlude

Product details

  • No. of pages: 1532
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: October 15, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128121023
  • eBook ISBN: 9780128122426
  • About the Editors

    Noel Rose

    Noel Rose
    Noel Rose was born in Stamford, Connecticut. He attended Yale University for his undergraduate education followed by the University of Pennsylvania for a Ph.D. and State University of New York at Buffalo for an MD. He was a member of the faculty of the State University of New York at Buffalo School of Medicine for a period of 20 years, rising through the ranks to become a professor of Microbiology and Medicine, Director of Clinical Laboratories and Director of the Center for Immunology. He then spent ten years at Wayne State University School of Medicine where he chaired the Department of Immunology and Microbiology. In 1981, he joined the faculty of Johns Hopkins University as chairman of the Department of Immunology and Infectious Diseases. He presently holds professorial appointments in the Departments of Pathology, Molecular Microbiology and Immunology, Medicine and Environmental Health Sciences at The Johns Hopkins University and directs the Center for Autoimmune Disease Research. Dr. Rose’s original investigations on the autoimmune basis of thyroid disease in 1956 opened the present era of research on autoimmunity. He has since investigated many areas of autoimmunity and related issues in clinical and basic immunology. Dr. Rose is the author or co-author of over 800 scientific papers and editor or co-editor of 24 books. He has received numerous honors, including two honorary doctoral degrees, election to fellowship in national or international societies, service in national and international organizations and editorial boards of leading journals.

    Affiliations and Expertise

    Director, Center for Autoimmune Disease Research, Bloomberg School of Public Health, John's Hopkins University, Baltimore, MD, USA

    Ian Mackay

    In the 1950s and 1960s Professor Mackay led the field of research into autoimmune diseases, coining the term ‘autoimmunity’. In 1963, he and Sir Macfarlane Burnet published a definitive monograph on the subject, firmly placing autoimmunity on the research map. Professor Mackay defined major autoimmune diseases of the liver and devised a life-saving protocol for autoimmune hepatitis that remains standard today. He also advanced knowledge on many other expressions of autoimmunity.

    Affiliations and Expertise

    Professor, Monash University, Clayton, Victoria, Australia

    Latest reviews

    (Total rating for all reviews)

    • SandraBoek Fri Aug 28 2020

      Autoimmune Disease

      The definitive textbook in autoimmune disease - how fortunate to have this 6th edition!

    • MarvinFritzler Sat Jan 25 2020

      The latest on Autoimmunity in one volume

      A very thorough information and reference source for the ever-expanding field of autoimmune diseases.