The Autoimmune Diseases - 4th Edition - ISBN: 9780125959612, 9780080454740

The Autoimmune Diseases

4th Edition

Editors: Ian Mackay Noel R Rose
eBook ISBN: 9780080454740
Hardcover ISBN: 9780125959612
Imprint: Academic Press
Published Date: 27th March 2006
Page Count: 1160
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Description

Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.

Key Features

New to This Edition:

  • Tissue-specific interventions to arrest or "cure" autoimmune disease
  • Bone marrow eradication and replacement
  • Both basic science and clinical medicine is covered
  • Boxed points to emphasize key features of each chapter

Readership

Basic and clinical scientists working in immunology, rheumatology and autoimmune diseases

Table of Contents

IMMUNOLOGIC BASIS OF AUTOIMMUNITY AUTOIMMUNITY: A HISTORY OF THE EARLY STRUGGLE FOR RECOGNITION STRUCTURAL AND FUNCTIONAL ASPECTS OF THE INNATE AND ADAPTIVE SYSTEMS OF IMMUNITY GENERAL FEATURES OF THE AUTOIMMUNE DISEASES ANTIGEN PRESENTATION, DENDRITIC CELLS AND AUTOIMMUNITY MHC COMPLEX AND AUTOIMMUNITY T CELLS AND AUTOIMMUNITY ROLE OF TH1 AND TH2 CELLS IN AUTOIMMUNITY TOLERANCE AND AUTOIMMUNITY – T CELLS REGULATORY T CELLS PEPTIDE-BASED INSTRUCTION OF SUPPRESSOR COMMITMENT IN NAÏVE T CELLS B CELLS AND AUTOIMMUNITY MEMORY B CELL DEVELOPMENT TOLERANCE AND AUTOIMMUNITY – B CELLS GENERATION OF T CELL ANTIGENIC DETERMINANTS IN AUTOIMMUNITY AND THEIR RECOGNITION APOPTOTIC CELLS AS A SOURCE OF AUTOANTIGENS EFFECTOR MECHANISMS OF AUTOIMMUNITY: ANTIBODIES, IMMUNE COMPLEXES FUNCTIONAL EFFECTS OF ANTIBODIES ADHESION MOLECULES AND CHEMOATTRACTANTS: RELEVANCE TO THE PATHOGENESIS AND TREATMENT OF AUTOIMMUNE DISEASES SIGNALING PATHWAYS IN T AND B LYMPHOCYTES GENETICS AND AUTOIMMUNITY: ROLE OF HLA IN AUTOIMMUNE DISEASES GENETICS AND AUTOIMMUNITY - NON-MHC INFECTIONS, IMMUNITY AND AUTOIMMUNITY NON-INFECTIOUS ENVIRONMENTAL AGENTS AND AUTOIMMUNITY VACCINES AND AUTOIMMUNE DISEASES SEX, PREGNANCY AND AUTOIMMUNITY

MULTISYSTEM DISEASES ANIMAL MODELS FOR AUTOIMMUNE DISEASE SYSTEMIC LUPUS ERYTHEMATOSUS, CHRONIC CUTANEOUS LUPUS, AND MIXED CONNECTIVE TISSUE DISEASE THE IMMUNOLOGY OF SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC SCLEROSIS- SCLERODERMA ANTIPHOSPHOLIPID SYNDROME SJÖGREN’S SYNDROME (AUTOIMMUNE EPITHELITIS) RHEUM ATOID ARTHRITIS SPONDYLOARTHRITIS AND CHRONIC IDIOPATHIC ARTHROPATHIES POLYMYOSITIS AND DERMATOMYOSITIS*

ENDOCRINE AND RELATED DISEASES THYROID DISEASE TYPE 1 DIABETES ADRENALITIS POLYENDOCRINE SYNDROMES AUTOIMMUNE GASTRITIS AND PERNICIOUS ANEMIA AUTOIMMUNE HYPOPHYSITIS

BLOOD DISEASES AUTOIMMUNE HEMOLYTIC ANEMIA AUTOIMMUNE THROMBOCYTOPENIC PURPURA AUTOIMMUNE NEUTROPENIA ACQUIRED APLASTIC ANEMIA CLOTTING DISORDERS

NEUROLOGIC DISEASES MULTIPLE SCLEROSIS PERIPHERAL NEUROPATHIES MYASTHENIA GRAVIS AND ANTI-RECEPTOR DISEASES OF THE NERVOUS SYSTEM UVEITIS INNER EAR DISEASE

INTESTINAL, HEPATIC, AND PANCREATIC DISEASES CELIAC DISEASE INFLAMMATORY BOWEL DISEASES: ULCERATIVE COLITIS AND CROHN’S DISEASE CHRONIC HEPATITIS PRIMARY BILIARY CIRRHOSIS PRIMARY SCLEROSING CHOLANGITIS AUTOIMMUNE PANCREATITIS

CUTANEOUS DISEASES BULLOUS SKIN DISEASES: PEMPHIGUS VULGARIS AND OTHER TYPES OF PEMPHIGUS NON-BULLOUS SKIN DISEASES: ALOPECIA, PSORIASIS, VITILIGO, URTICARIA

UROGENITAL DISEASES KIDNEY: GOODPASTURE’S DISEASE, LUPUS NEPHRITIS, ANCA-ASSOCIATED GLOMERULONEPHRITIS AUTOIMMUNE ORCHITIS AND MALE INFERTILITY OOPHORITIS

CARDIOVASCULAR AND PULMONARY DISEASES RHEUMATIC HEART DISEASE MYOCARDITIS AND DILATED CARDIOMYOPATHY ATHEROSCLEROSIS: AUTOIMMUNITY TO HEAT-SHOCK PROTEINS NECROTIZING ARTERITIS AND SMALL VESSEL VASCULITIS VASCULITIS IDIOPATHIC BRONCHIOLITIS OBLITERANS, IDIOPATHIC PULMONARY FIBROSIS, AND THE AUTOIMMUNE DISORDERS OF THE LUNG

NEOPLASIA AND AUTOIMMUNITY PARANEOPLASTIC DISEASES – AUTOIMMUNE RESPONSES TO TUMOR ANTIGENS LYMPHOMA AND AUTOIMMUNE DISEASE APOPTOSIS AND AUTOIMMUNITY - LYMPHOPROLIFERATIVE SYNDROMES

MISCELLANEOUS CAMEOS

DIAGNOSIS, PREVENTION, AND THERAPY AUTOANTIBODY ASSAYS, TESTING AND STANDARDIZATION T-CELL ASSAYS PREDICTION OF AUTOIMMUNE DISEASE THE PREVENTION OF AUTOIMMUNE DISEASE: TYPE 1 DIABETES AS A PARADIGM EMERGING THERAPIES IN AUTOIMMUNE DISEASES EPILOGUE - ADVOCATUS DIABOLI

Details

No. of pages:
1160
Language:
English
Copyright:
© Academic Press 2006
Published:
Imprint:
Academic Press
eBook ISBN:
9780080454740
Hardcover ISBN:
9780125959612

About the Editor

Ian Mackay

Affiliations and Expertise

Monash University, Clayton, Victoria, Australia

Noel R Rose

Noel Rose was born in Stamford, Connecticut. He attended Yale University for his undergraduate education followed by the University of Pennsylvania for a Ph.D. and State University of New York at Buffalo for an MD. He was a member of the faculty of the State University of New York at Buffalo School of Medicine for a period of 20 years, rising through the ranks to become a professor of Microbiology and Medicine, Director of Clinical Laboratories and Director of the Center for Immunology. He then spent ten years at Wayne State University School of Medicine where he chaired the Department of Immunology and Microbiology. In 1981, he joined the faculty of Johns Hopkins University as chairman of the Department of Immunology and Infectious Diseases. He presently holds professorial appointments in the Departments of Pathology, Molecular Microbiology and Immunology, Medicine and Environmental Health Sciences at The Johns Hopkins University and directs the Center for Autoimmune Disease Research. Dr. Rose’s original investigations on the autoimmune basis of thyroid disease in 1956 opened the present era of research on autoimmunity. He has since investigated many areas of autoimmunity and related issues in clinical and basic immunology. Dr. Rose is the author or co-author of over 800 scientific papers and editor or co-editor of 24 books. He has received numerous honors, including two honorary doctoral degrees, election to fellowship in national or international societies, service in national and international organizations and editorial boards of leading journals.

Affiliations and Expertise

Director, Center for Autoimmune Disease Research, Bloomberg School of Public Health, John's Hopkins University, Baltimore, MD, USA

Reviews

"...edited by Noel R. Rose and Ian R. Mackay, widely recognized experts in autoimmunity and its pathophysiological and clinical aspects...This thoughtfully updated new edition takes into consideration important developments in basic and clinical science...This book will be a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune diseases, to scientists who want to follow developments in the field, and to all those who enjoyed the previous edition." - Martha M. Eibl, M.D. for NEW ENGLAND JOURNAL OF MEDICINE (Jan 2006)