Description

Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.

Key Features

New to This Edition: * Tissue-specific interventions to arrest or "cure" autoimmune disease * Bone marrow eradication and replacement * Both basic science and clinical medicine is covered * Boxed points to emphasize key features of each chapter

Readership

Basic and clinical scientists working in immunology, rheumatology and autoimmune diseases

Table of Contents

IMMUNOLOGIC BASIS OF AUTOIMMUNITY AUTOIMMUNITY: A HISTORY OF THE EARLY STRUGGLE FOR RECOGNITION STRUCTURAL AND FUNCTIONAL ASPECTS OF THE INNATE AND ADAPTIVE SYSTEMS OF IMMUNITY GENERAL FEATURES OF THE AUTOIMMUNE DISEASES ANTIGEN PRESENTATION, DENDRITIC CELLS AND AUTOIMMUNITY MHC COMPLEX AND AUTOIMMUNITY T CELLS AND AUTOIMMUNITY ROLE OF TH1 AND TH2 CELLS IN AUTOIMMUNITY TOLERANCE AND AUTOIMMUNITY – T CELLS REGULATORY T CELLS PEPTIDE-BASED INSTRUCTION OF SUPPRESSOR COMMITMENT IN NAÏVE T CELLS B CELLS AND AUTOIMMUNITY MEMORY B CELL DEVELOPMENT TOLERANCE AND AUTOIMMUNITY – B CELLS GENERATION OF T CELL ANTIGENIC DETERMINANTS IN AUTOIMMUNITY AND THEIR RECOGNITION APOPTOTIC CELLS AS A SOURCE OF AUTOANTIGENS EFFECTOR MECHANISMS OF AUTOIMMUNITY: ANTIBODIES, IMMUNE COMPLEXES FUNCTIONAL EFFECTS OF ANTIBODIES ADHESION MOLECULES AND CHEMOATTRACTANTS: RELEVANCE TO THE PATHOGENESIS AND TREATMENT OF AUTOIMMUNE DISEASES SIGNALING PATHWAYS IN T AND B LYMPHOCYTES GENETICS AND AUTOIMMUNITY: ROLE OF HLA IN AUTOIMMUNE DISEASES GENETICS AND AUTOIMMUNITY - NON-MHC INFECTIONS, IMMUNITY AND AUTOIMMUNITY NON-INFECTIOUS ENVIRONMENTAL AGENTS AND AUTOIMMUNITY VACCINES AND AUTOIMMUNE DISEASES SEX, PREGNANCY AND AUTOIMMUNITY MULTISYSTEM DISEASES ANIMAL MODELS FOR AUTOIMMUNE DISEASE SYSTEMIC LUPUS ERYTHEMATOSUS, CHRONIC CUTANEOUS LUPUS, AND MIXED CONNECTIVE TISSUE DISEASE THE IMMUNOLOGY OF SYSTEMIC LUPUS ERYTHEMATOSUS SYSTEMIC SCLEROSIS- SCLERODERMA ANTIPHOSPHOLIPID SYNDROME SJÖGREN’S SYNDROME (AUTOIMMUNE EPITHELITIS)

Details

No. of pages:
1160
Language:
English
Copyright:
© 2006
Published:
Imprint:
Academic Press
Electronic ISBN:
9780080454740
Print ISBN:
9780125959612

Reviews

"...edited by Noel R. Rose and Ian R. Mackay, widely recognized experts in autoimmunity and its pathophysiological and clinical aspects...This thoughtfully updated new edition takes into consideration important developments in basic and clinical science...This book will be a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune diseases, to scientists who want to follow developments in the field, and to all those who enjoyed the previous edition." - Martha M. Eibl, M.D. for NEW ENGLAND JOURNAL OF MEDICINE (Jan 2006)