The Autoimmune Diseases

5th Edition

Editors: Ian Mackay Noel R Rose
Hardcover ISBN: 9780123849298
eBook ISBN: 9780123849304
Imprint: Academic Press
Published Date: 23rd December 2013
Page Count: 1304
Tax/VAT will be calculated at check-out
Compatible Not compatible
VitalSource PC, Mac, iPhone & iPad Amazon Kindle eReader
ePub & PDF Apple & PC desktop. Mobile devices (Apple & Android) Amazon Kindle eReader
Mobi Amazon Kindle eReader Anything else

Institutional Access


Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors.

Key Features

  • Gives a thorough and an important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and therapy
  • Provides thorough, up-to-date information on specific diseases, along with clinical applications, in an easily found reference for clinicians and researchers interested in certain diseases
  • Keeps readers abreast of current trends and emerging areas in the field
  • Ensures that content is not only up-to-date, but applicable and relevant


Basic and clinical scientists working in immunology, rheumatology and autoimmune diseases

Table of Contents

List of Contributors


Present at the Beginning

Part 1: Immunologic Basis of Autoimmunity

Chapter 1. Autoimmune Disease: The Consequence of Disturbed Homeostasis

Evolution of the Autoimmune Response

A Phylogenetic Perspective

Self and Non-Self, and the Nature of Autoantigens

Autoimmunity and Autoimmune Disease

The Common Threads

The “Proper Study…”

Towards the Future

The Last Word


Chapter 2. Autoimmunity: A History of the Early Struggle for Recognition

The Search for Autoantibodies

Challenges to the Thesis

The Shift to Immunochemistry

The Return of Immunobiology

Concluding Remarks


Chapter 3. General Features of Autoimmune Disease

Innate Immune Activation

Cells of the Adaptive Immune System

Defining Autoimmune Disease

Prevalence of Autoimmunity

Genetics of Autoimmunity

Hormones and Autoimmunity

Autoimmunity and Central Tolerance

Autoimmunity and Peripheral Tolerance

Triggers of Autommunity

Activation of the Immune System

Role of Antigen as a Driver of Autoimmunity

Defective Downregulation of an Immune Response

Regulatory Lymphocytes

The Role of the Gut Microbiota in Autoimmunity

Mechanisms of Tissue Damage

Flares and Remissions During Disease

Therapeutic Advances

Goals for the Future

Concluding Remarks



Chapter 4. The Concept of Autoinflammatory Diseases

Historical Perspective


Spectrum from Autoimmune to Autoinflammatory Disease

Mechanisms in Autoinflammation

Classical Hereditary Autoinflammatory Disorders

Polygenic or Acquired Autoinflammatory Disorders

Autoinflammatory Mechanisms of Disea


No. of pages:
© Academic Press 2014
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Ian Mackay

Affiliations and Expertise

Monash University, Clayton, Victoria, Australia

Noel R Rose

Noel Rose was born in Stamford, Connecticut. He attended Yale University for his undergraduate education followed by the University of Pennsylvania for a Ph.D. and State University of New York at Buffalo for an MD. He was a member of the faculty of the State University of New York at Buffalo School of Medicine for a period of 20 years, rising through the ranks to become a professor of Microbiology and Medicine, Director of Clinical Laboratories and Director of the Center for Immunology. He then spent ten years at Wayne State University School of Medicine where he chaired the Department of Immunology and Microbiology. In 1981, he joined the faculty of Johns Hopkins University as chairman of the Department of Immunology and Infectious Diseases. He presently holds professorial appointments in the Departments of Pathology, Molecular Microbiology and Immunology, Medicine and Environmental Health Sciences at The Johns Hopkins University and directs the Center for Autoimmune Disease Research. Dr. Rose’s original investigations on the autoimmune basis of thyroid disease in 1956 opened the present era of research on autoimmunity. He has since investigated many areas of autoimmunity and related issues in clinical and basic immunology. Dr. Rose is the author or co-author of over 800 scientific papers and editor or co-editor of 24 books. He has received numerous honors, including two honorary doctoral degrees, election to fellowship in national or international societies, service in national and international organizations and editorial boards of leading journals.

Affiliations and Expertise

Director, Center for Autoimmune Disease Research, Bloomberg School of Public Health, John's Hopkins University, Baltimore, MD, USA


"...incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders."--Anticancer Research, February 2015

"This authoritative book on autoimmune diseases is useful for clinicians and basic scientists alike. It is easy to read but is also useful as a reference. The authors provide an extensive overview of autoimmunity, ranging from basic mechanisms of disease to clinical features. Rating - 4 Stars", August 2014

"...edited by Noel R. Rose and Ian R. Mackay, widely recognized experts in autoimmunity and its pathophysiological and clinical aspects. This thoughtfully updated new edition takes into consideration important developments in basic and clinical science. This book will be a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune diseases, to scientists who want to follow developments in the field, and to all those who enjoyed the previous edition."--Martha M. Eibl, M.D. for NEW ENGLAND JOURNAL OF MEDICINE, Jan 2006