The Antigens

The Antigens

Volume III

1st Edition - September 28, 1975

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  • Editor: Michael Sela
  • eBook ISBN: 9781483269566

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The Antigens, Volume III is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from microbial polysaccharides and lymphocytic receptors for antigens to antigenic determinants and antibody-combining sites. Allergens and the genetics of allergy are also explored. Comprised of seven chapters, this volume begins with a review of microbial polysaccharides as antigens, followed by a discussion on antigenic determinants and their specific reaction with antibody-combining sites. The reader is then introduced to the reaction of antigens with their specific receptors on lymphocytes. The next four chapters are concerned with several categories of more complex antigens which, in most cases, have yet to be characterized adequately at a molecular level: allergens, histocompatibility antigens, antigens of Mycoplasmatales and chlamydiae, and animal viruses. The book concludes with an analysis of virus infections and the immune responses they elicit. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    Chapter 1 Microbial Polysaccharides

    I. Introduction

    II. Chemistry of Microbial Polysaccharide Antigens

    III. Immunochemistry of Microbial Polysaccharide Antigens

    IV. Immunobiology of Microbial Polysaccharide Antigens

    V. Summary and Conclusions


    Chapter 2 Antigenic Determinants and Antibody Combining Sites

    I. Introduction

    II. The Structural Specificity of Hapten — Antibody Interactions

    III. Antigenic Determinants

    IV. The Antibody Combining Site

    V. Immunogenic Determinants

    VI. Concluding Remarks


    Chapter 3 Lymphocytic Receptors for Antigens

    I. Introduction

    II. Historical

    III. Two Classes of Lymphocytes

    IV. The Lymphocyte Plasma Membrane

    V. Relevant Properties of Immunoglobulins

    VI. Immunoglobulins on the Lymphocyte Plasma Membrane

    VII. The Binding of Antigen to Lymphocytes

    VIII. Specificity and Immunocompetence of ABC

    IX. Receptors on Lymphocytes for Antigens

    X. Antigens, The Antigen —Receptor Complex, and Mitogens

    XI. Inside the B Cell


    Chapter 4 Allergens and the Genetics of Allergy

    I. Introduction

    II. Historical Development (1872-about 1960)

    III. Nomenclature

    IV. Modern Allergen Research

    V. Nature of Allergenic Sensitization and Stimulation

    VI. Genetics of Allergy

    VII. Practical Considerations

    VIII. Concluding Remarks


    Chapter 5 A Biologic and Chemical Profile of Histocompatibility Antigens

    I. Introduction

    II. History

    III. Genetics

    IV. Serologie Detection of H Antigens

    V. Cell Surface Expression of H Antigens

    VI. Cross-Reactivity of H Antigens

    VII. Extraction, Purification, and Biologic Activity of Soluble H Antigens

    VIII. Chemical and Molecular Nature of HL-A Antigens

    IX. Perspectives


    Chapter 6 Antigens of the Mycoplasmatales and Chlamydiae

    I. Introduction

    II. Classification and Nomenclature

    III. Biology

    IV. Phylogenetic Relationships

    V. Antigenic Analysis of Mycoplasmata

    VI. Antigenic Analysis of Chlamydiae

    VII. Growth Inhibition and Mycoplasmacidal Activity of Serum

    VIII. Antigenic Structure


    Chapter 7 Virus Infections and the Immune Responses They Elicit

    I. Introduction

    II. Viral Antigens

    III. Humoral Responses

    IV. Secretory Antibody Responses

    V. Thymus Dependence of Viral Antigens

    VI. B Lymphocyte Memory and "Original Antigenic Sin"

    VII. Neutralization

    VIII. Capacity of Macrophages to Support Virus Replication

    IX. Ontogeny of Macrophage Resistance to Viral Infections

    X. Surface Changes of Virus-Infected Cells

    XI. Evidence for Cell-Mediated Immunity to Viral Antigens

    XII. Persistence of Immunity to Viruses

    XIII. Tolerance to Viral Antigens

    XIV. Cooperative Effects of Viral Antigens on Immunogenicity

    XV. Influence of Virus Infections on Immune Responses

    XVI. Concluding Remarks


    Author Index

    Subject Index

Product details

  • No. of pages: 640
  • Language: English
  • Copyright: © Academic Press 1975
  • Published: September 28, 1975
  • Imprint: Academic Press
  • eBook ISBN: 9781483269566

About the Editor

Michael Sela

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