The Antigens - 1st Edition - ISBN: 9780126355031, 9781483269566

The Antigens

1st Edition

Volume III

Editors: Michael Sela
eBook ISBN: 9781483269566
Imprint: Academic Press
Published Date: 28th September 1975
Page Count: 640
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Description

The Antigens, Volume III is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from microbial polysaccharides and lymphocytic receptors for antigens to antigenic determinants and antibody-combining sites. Allergens and the genetics of allergy are also explored.

Comprised of seven chapters, this volume begins with a review of microbial polysaccharides as antigens, followed by a discussion on antigenic determinants and their specific reaction with antibody-combining sites. The reader is then introduced to the reaction of antigens with their specific receptors on lymphocytes. The next four chapters are concerned with several categories of more complex antigens which, in most cases, have yet to be characterized adequately at a molecular level: allergens, histocompatibility antigens, antigens of Mycoplasmatales and chlamydiae, and animal viruses. The book concludes with an analysis of virus infections and the immune responses they elicit.

This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Table of Contents


List of Contributors


Preface


Contents of Other Volumes


Chapter 1 Microbial Polysaccharides


I. Introduction


II. Chemistry of Microbial Polysaccharide Antigens


III. Immunochemistry of Microbial Polysaccharide Antigens


IV. Immunobiology of Microbial Polysaccharide Antigens


V. Summary and Conclusions


References


Chapter 2 Antigenic Determinants and Antibody Combining Sites


I. Introduction


II. The Structural Specificity of Hapten — Antibody Interactions


III. Antigenic Determinants


IV. The Antibody Combining Site


V. Immunogenic Determinants


VI. Concluding Remarks


References


Chapter 3 Lymphocytic Receptors for Antigens


I. Introduction


II. Historical


III. Two Classes of Lymphocytes


IV. The Lymphocyte Plasma Membrane


V. Relevant Properties of Immunoglobulins


VI. Immunoglobulins on the Lymphocyte Plasma Membrane


VII. The Binding of Antigen to Lymphocytes


VIII. Specificity and Immunocompetence of ABC


IX. Receptors on Lymphocytes for Antigens


X. Antigens, The Antigen —Receptor Complex, and Mitogens


XI. Inside the B Cell


References


Chapter 4 Allergens and the Genetics of Allergy


I. Introduction


II. Historical Development (1872-about 1960)


III. Nomenclature


IV. Modern Allergen Research


V. Nature of Allergenic Sensitization and Stimulation


VI. Genetics of Allergy


VII. Practical Considerations


VIII. Concluding Remarks


References


Chapter 5 A Biologic and Chemical Profile of Histocompatibility Antigens


I. Introduction


II. Hi

Details

No. of pages:
640
Language:
English
Copyright:
© Academic Press 1975
Published:
Imprint:
Academic Press
eBook ISBN:
9781483269566

About the Editor

Michael Sela

Ratings and Reviews