The Antigens

The Antigens

Volume I

1st Edition - January 28, 1974

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  • Editor: Michael Sela
  • eBook ISBN: 9781483269894

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Description

The Antigens, Volume I is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology, structure and function, their initiation of the immune response, and the nature of the products of this response. The nature of the reaction of antigens with antibodies and with sensitized cells is also explored. Comprised of seven chapters, this volume begins with a discussion on the antigenic functions of nucleic acids as well as their immunogenicity, hapten functions, and serologic reactions. The reader is then introduced to the immunochemistry and antigenic determinants of enzymes, along with the structure and phylogeny of immunoglobulins and immunoglobulin allotypes. The evolution of proteins and their structure and function is also considered, paying particular attention to evolution by the random fixation of selectively neutral alleles, the rates of protein evolution, gene duplication, and divergence or convergence. The final chapter is devoted to the chemistry and biology of immunoglobulin E as well as the regulation of formation of their antibodies. This book will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Table of Contents


  • List of Contributors

    Preface

    Contents of Volume II

    Chapter 1 Nucleic Acid Antigens

    I. Introduction

    II. Criteria for Establishing a Nucleic Acid Immune System

    III. Possible Antigenic Determinants and the Meaning of Specificity

    IV. Experimentally Induced Antibodies to Nucleic Acids

    V. The Natural Occurence of Antibodies to Nucleic Acids

    VI. Applications of Antibodies to Nucleic Acids

    VII. Conclusion

    References

    Chapter 2 Immunochemistry of Enzymes

    I. Introduction

    II. Inhibition and Enhancement of Enzyme Activity by Specific Antibodies

    III. Immunologic Approach to Evolution of Enzymes

    IV. Antigenic Determinants of Enzymes

    V. Structure-Function Correlation Pertaining to Catalytic and Immunologic Activities

    VI. Immunologic Relationship Between Enzymes and Their Inactive Precursors

    VII. Enzymes and Apoenzymes

    VIII. Multiple Forms of Enzymes

    IX. Allosteric Enzymes

    X. Individual Enzymes: Immunochemical Characterization

    XI. Concluding Remarks

    References

    Chapter 3 Structure of Immunoglobulins

    I. Introduction

    II. History

    III. Nomenclature

    IV. Tertiary and Quanternary Structure

    V. Disulfide Bond Arrangements

    VI. Primary Structure of Immunoglobulin Chains

    VII. The Nature of the Antibody Combining Site

    VIII. Immunoglobulins as Antigens

    IX. Immunoglobulin Genetic Markers

    X. Immunoglobulin Gene Translocation

    XI. The Origin of Immunoglobulin Diversity

    XII. Future Prospects

    References

    Chapter 4 Immunoglobulin Allotypes

    I. Introduction

    II. Allotypes of Rabbit (Oryctolagus cuniculus) Immunoglobulins

    III. The Allotypes and Idiotypes of Mouse (Mus musculus) Immunoglobulins

    IV. Allotypes of Human Immunoglobulins

    References

    Chapter 5 The Evolution of Proteins

    I. Introduction

    II. Goals of the Study of Protein Evolution

    III. Data Collection for Studies of Protein Evolution

    IV. The Evolution of Structure and Function

    V. Evolution by the Random Fixation of Selectively Neutral Alleles

    VI. The Rates of Protein Evolution

    VII. Gene Duplication and Divergence or Convergence

    VIII. The Future

    Refereces

    Chapter 6 Phylogeny of Immunoglobulins

    I. Introduction

    II. Natural Agglutinins

    III. Cyclostome Immunoglobulins

    IV. Elasmobranch Immunoglobulins

    V. OSteichthyes Immunoglobulins

    VI. Amphibian Immunoglobulins

    VII. Reptile Immunoglobulins

    VIII. Avian Immunoglobulins

    IX. Amino Acid Sequence Analysis of Nonmammalian Vertebrate Immunoglobulins

    X. The Specificity, Affinity, and Heterogeneity of Antibody Response in Nonmammalian Vertebrates

    XI. Evolution of a Four-Chain Immunoglobulin Molecule

    XII. Conclusions and Summary

    Refereces

    Chapter 7 Chemistry and Biology of Immunoglobulin E

    I. Introduction

    II. Identification of IgE

    III. Physicochemical Properties and Structure

    IV. Immunologic Properties

    V. Formation and Metabolism

    VI. Molecular and Cellular Basis of Sensitization

    VII. Immune Mechanisms of Reaginic Hypersensitivity Reactions

    VIII. Biologic Role of IgE System

    IX. Regulation of IgE Antibody Formation

    References

    Author Index

    Subject Index

Product details

  • No. of pages: 588
  • Language: English
  • Copyright: © Academic Press 1974
  • Published: January 28, 1974
  • Imprint: Academic Press
  • eBook ISBN: 9781483269894

About the Editor

Michael Sela

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