The Alkaloids

The Alkaloids

Chemistry and Physiology

1st Edition - January 1, 1952

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  • Editors: R. H. F. Manske, H. L. Holmes
  • eBook ISBN: 9781483221977

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Description

The Alkaloids: Chemistry and Physiology, Volume II focuses on strychnine and morphine alkaloids. This book discusses the elucidation of the structure of morphine, codeine, and thebaine; synthetic hydrophenanthrenes related to the morphine alkaloids; and stereochemistry of the morphine alkaloids and sinomenine. The elucidation of the constitution of sinomenine, biological effects of colchicine, chemistry of individual alkaloids, and alkaloids of gelsemium species are also elaborated. This text likewise covers the isolation of the alkaloids, phenanthrene nucleus of morphine, fission around the nitrogen atom, and synthetic hydrophenanthrenes related to the morphine alkaloids. This volume is useful to chemists and researchers conducting work on alkaloid chemistry.

Table of Contents


  • Preface

    The Morphine Alkaloids. I

    I. Introduction

    II. Elucidation of the Structure of Morphine, Codeine, and Thebaine

    III. The Reactions of Morphine, Codeine, and Related Products

    IV. The Reactions of Thebaine and Related Products

    V. Synthetic Hydrophenanthrenes Related to the Morphine Alkaloids

    VI. Table of Physical Constants

    VII. References

    The Morphine Alkaloids. II

    I. Introduction

    II. The Reactions of Morphine, Codeine and Neopine

    III. The Reactions of Thebaine and Related Products

    IV. The Stereochemistry of the Morphine Alkaloids and Sinomenine

    V. Rearrangement and Elimination Reactions

    VI. The Synthesis of Related Products

    VII. Tables of Physical Constants

    VIII. References

    Sinomenine

    I. Physiological Action, Isolation and Color Reactions

    II. Elucidation of the Constitution of Sinomenine

    III. Reactions of Sinomenine and Related Products

    IV. Partial Synthesis of the Antipode of 1-Bromosinomeninone

    V. Table of Physical Constants

    VI. References

    Colchicine

    I. Chemistry of Colchicine

    II. Biological Effects of Colchicine

    III. References

    Alkaloids of the Amaryllidaceae

    I. Occurrence and General History

    II. Chemistry of Individual Alkaloids

    III. References

    Acridine Alkaloids

    I. Introduction

    II. Degradation

    III. Conclusion

    IV. References

    The Indole Alkaloids

    I. Introduction

    II. The Simple Bases

    III. The Ergot Alkaloids

    IV. The Alkaloids of Peganum harmala

    V. Alkaloids of Evodia rutaecarpa

    VI. The Alkaloids of Yohimbe

    VII. The Quebracho Alkaloids

    VIII. Alkaloids of Rauwolfia Species

    IX. Alkaloids of Gelsemium Species

    X. The Alkaloids of Calycanthaceae

    XI. Alkaloids of Calabar Bean

    XII. The Iboga Alkaloids

    XIII. Alkaloids of Alstonia Species

    XIV. Alkaloids of Geissospermum vellosii

    XV. Quinamine and Cinchonamine

    XVI. C-Dihydrotoxiferine-I

    XVII. Tables

    XVIII. References

    The Erythrina Alkaloids

    I. Introduction

    II. Distribution

    III. Isolation of the Alkaloids

    IV. The Free Alkaloids

    V. The Combined Alkaloids

    VI. The Liberated Alkaloids

    VII. Table of Physical Constants

    VIII. References

    The Strychnos Alkaloids. Part II

    I. Introduction

    II. Elucidation of the Structure of Strychnine and Brucine

    III. Vomicine and Vomipyrine (425-436)

    IV. The Structure and Stereochemistry of Strychnine

    V. Tables of Physical Constants

    VI. References

    Author Index

    Subject Index

    Chapter VIII

    Part I The Morphine Alkaloids. I

    1. Introduction

    II. Elucidation of the Structure of Morphine, Codeine, and Thebaine

    1. The Phenanthrene Nucleus of Morphine

    2. Oxazine and Isoquinoline Formulas for Morphine

    3. Pyridine Formulas for Morphine

    4. Transitional Formulas

    5. The Camphane and Modern Formulas

    6. Problems Remaining

    III. The Reactions of Morphine, Codeine, and Related Products

    1. Reduction

    2. Oxidation

    3. Substitution in the Benzene Nucleus

    4. Fission around the Nitrogen Atom

    5. The Action of Organometallic Compounds

    6. The Codides and Morphides

    7. The Desoxycodeines

    IV. The Reactions of Thebaine and Related Products

    1. Reduction

    2. Oxidation

    3. The Action of Organometallic Compounds

    4. Fission Around the Nitrogen Atom

    5. Rearrangements

    V. Synthetic Hydrophenanthrenes Related to the Morphine Alkaloids

    VI. Table of Physical Constants

    VII. References

Product details

  • No. of pages: 596
  • Language: English
  • Copyright: © Academic Press 1952
  • Published: January 1, 1952
  • Imprint: Academic Press
  • eBook ISBN: 9781483221977

About the Editors

R. H. F. Manske

Affiliations and Expertise

Dominion Rubber Research Laboratory, Guelph, Ontario

H. L. Holmes

Affiliations and Expertise

University of British Columbia Vancouver, Canada

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