The Alkaloids

The Alkaloids

Chemistry and Physiology

1st Edition - January 1, 1955

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  • Editor: R. H. F. Manske
  • eBook ISBN: 9781483221922

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The Alkaloids: Chemistry and Physiology, Volume V: Pharmacology deals with the chemistry and pharmacology of the alkaloids. This book discusses the general pharmacology of morphine, cryptopine-like compounds, toad poisons, and respiratory stimulants. The appraisal of the utility of alkaloids as antimalarials, uterine stimulants, metabolism of cocaine, and optical isomerism-activity relationship are also elaborated. This publication likewise covers the parasympathetic blocking agents as mydriatics, methods of measuring mydriatic activity, alkaloids exhibiting curariform activity, and minor alkaloids of unknown structure. Other topics include the fate of morphine, tropane group, factors affecting cocaine anesthesia, and sympathomimetic mydriatics. This volume is intended for chemists and pharmacologists concerned with alkaloids.

Table of Contents

  • Preface v

    Narcotics and Analgesics

    I. Introduction

    II. General Pharmacology of Morphine

    III. Analgesia

    IV. Addiction and Withdrawal Phenomena

    V. Morphine Derivatives and Related Analgesics

    VI. Fate of Morphine

    VII. References

    Cardioactive Alkaloids

    I. Introduction

    II. Cinchona Alkaloids

    III. Cryptopine-Like Compounds

    IV. Sparteine and Related Substances

    V. Rauwolfia Alkaloids

    VI. Toad Poisons (Bufotoxins)

    VII. Erythrophleum Alkaloids

    VIII. References

    Respiratory Stimulants

    I. Introduction

    II. Choline Group

    III. Veratrine Group

    IV. Nicotine Group

    V. Tropane Group

    VI. Sympathomimetic Group

    VII. Purine Bases

    VIII. References


    I. Introduction

    II. Cinchona Alkaloids

    III. Other Alkaloids

    IV. Appraisal of the Utility of Alkaloids as Antimalarials

    V. References

    Uterine Stimulants

    I. Introduction

    II. Ergot Alkaloids

    III. Cinchona Alkaloids

    IV. Sparteine and Related Alkaloids

    V. Muscarine, Arecoline, Pilocarpine, and Physostigmine

    VI. Isoquinoline Alkaloids

    VII. Miscellaneous Alkaloids

    VIII. Discussion

    IX. References

    Alkaloids as Local Anesthetics

    I. History

    II. Derivatives of Cocaine

    III. Metabolism of Cocaine

    IV. Other Alkaloids

    V. Factors Affecting Cocaine Anesthesia

    VI. Evolution of Anesthetic Structures

    VII. References

    Pressor Alkaloids

    I. Introduction

    II. Aromatic Amines

    III. Alkyl Amines

    IV. Indolealkyl Amines

    V. Synthetic Products of Medicinal Interest

    VI. Structure-Activity Relationship

    VII. Optical Isomerism-Activity Relationship

    VIII. References

    Mydriatic Alkaloids

    I. Innervation and Musculature of the Eye

    II. Methods of Measuring Mydriatic Activity

    III. Parasympathetic Blocking Agents as Mydriatics

    IV. Sympathomimetic Mydriatics

    V. References

    Curare-Like Effects

    I. Introduction

    II. Curariform Activity

    III. Alkaloids Exhibiting Curariform Activity

    IV. Synthetic Curarizing Agents

    V. References

    The Lycopodium Alkaloids

    I. Occurrence

    II. Structure

    III. Pharmacology

    IV. References

    Minor Alkaloids of Unknown Structure

    I. Introduction

    II. Plants Containing Alkaloids of Unknown Structure

    III. References

    Author Index—Volume V

    Subject Index—Volume V

    Subject Index—Volumes I-IV

Product details

  • No. of pages: 398
  • Language: English
  • Copyright: © Academic Press 1955
  • Published: January 1, 1955
  • Imprint: Academic Press
  • eBook ISBN: 9781483221922

About the Editor

R. H. F. Manske

Affiliations and Expertise

Dominion Rubber Research Laboratory, Guelph, Ontario

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