Textbook of Neuropathology

Textbook of Neuropathology

2nd Edition - January 1, 1946

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  • Author: Arthur Weil
  • eBook ISBN: 9781483225968

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Textbook of Neuropathology, Second Edition covers some of the significant advances in understanding the theoretical and experimental aspects of neuropathology. Neuropathology is the study of the nervous tissue in disease and the determination of deviations of its structures from the normal. This edition is composed of 13 chapters, and begins with the description of the chemical changes occurring in the cell through autolysis and fixation. The subsequent chapters are devoted to studies on better understanding of the vitamin deficiencies, the discovery of the sulfonamides and their contribution to the therapy of meningitis, and the different forms of shock treatment applied to selected cases of neurosis and psychosis. The remaining chapters explore the contribution of neuropathological investigation in various medical conditions, including anemic softening, arteriosclerosis, inflammation, infections, intoxications, injuries, degenerative diseases, tumors, and congenital malformations. This book will be of use to neuropathologists and workers and researchers in the allied fields.

Table of Contents

  • Preface to the First Edition

    Preface to the Second Edition


    Chapter I. Changes through Autolysis and Fixation


    Postmortem Infection

    Action of Ferments


    Effect of Formalin Fixation

    Effect of Alcohol Fixation

    Corpora Amylacea and Amyloid Bodies

    Chapter II. Diseases of the Neuron

    Normal Variations and Postmortem Changes

    Specific Reactions



    Glycogen and Amyloid

    Chapter III. The Glia and Its Pathology




    Degenerative (Regressive) Changes of Glia Cells

    Chapter IV. Pathology of the Myelin Sheath and the Axis-Cylinder

    Experimental Demyelinization

    Degeneration of the Myelin Sheaths

    Disease of the Axis-Cylinders

    Regeneration of the Peripheral Nerves

    Chapter V. Anemic Softening

    The Oxygen Consumption of the Brain


    Etiology of Anemia

    Anemic Softening of the Brain

    Hemorrhagic Softening of the Brain

    Brain Purpura

    Chapter VI. Arteriosclerosis

    Vascular Disease in Arteriosclerosis



    Calcification of the Media

    Arteriocapillary Fibrosis

    Pathology of the Brain


    The Arteriosclerotic Brain

    Arteriosclerosis of the Spinal Cord

    Chapter VII. Inflammation


    The Hemato-Encephalic Barrier

    Chapter VIII. Infections

    The Mode of Invasion of Micro-organisms

    Classification of Infections

    1. Meningo-Encephalitis

    2. Metastatic or Embolic Disseminated Encephalitis

    3. Diffuse Polio-Encephalitis

    4. Disseminated Polio-Encephalitis

    5. Disseminated Encephalitis with Demyelinization

    6. Diffuse Perivenous Focal Encephalitis

    Tissue Alterations Following Infection

    Exudation and Proliferation


    Acute Leptomeningitis

    Chronic Leptomeningitis


    Epidemic Meningitis

    Nonepidemic Forms of Purulent Meningitis

    Infectious Encephalitis and Myelitis

    Purulent Encephalitis and Brain Abscess

    Purulent Myelitis

    Acute Epidemic Encephalitis

    Acute Poliomyelitis

    Tuberculosis of the Central Nervous System

    Tuberculous Meningitis


    Pott's Disease

    Syphilis of the Central Nervous System

    Syphilitic Meningitis


    Syphilitic Meningo-Encephalitis

    Syphilitic Meningomyelitis

    Vascular Syphilis

    General Paralysis

    Tabes Dorsalis

    Blastomyces Infections

    Protozoal Infections

    Acute Disseminated Encephalomyelitis

    Disseminated Sclerosis

    Diffuse Sclerosis

    Chapter IX. Intoxications


    Alkaloids and Narcotics

    Lead and Arsenic

    Insulin and Metrazol

    Carbon Monoxide

    Endogenous Intoxication

    Meat Poisoning

    Liver Disease



    Subacute Combined Degeneration

    Chapter X. Injuries

    The Brain


    Skull Fractures and Brain Wounds

    The Spinal Cord



    The Peripheral Nerves

    Effects of X Rays, Heat, and Electrical Current

    Chapter XI. Degenerative Diseases

    The Muscular Dystrophies

    Dystrophia Musculorum

    Dystrophia Myotonica

    Myotonia Congenita

    Myasthenia Gravis

    The Amyotrophies

    Progressive Neuropathic (Peroneal) Muscular Atrophy

    Progressive Muscular Atrophies

    Amyotrophic Lateral Sclerosis

    The Heredofamilial Ataxias


    Chronic Progressive Chorea (Huntington)

    Infectious Chorea


    Familial Amaurotic Idiocy

    Cerebral Cortical Degeneration

    Senile Cortical Degeneration

    Pick's Disease (Lobar Sclerosis)

    Chapter XII. Tumors

    Tumors of the Meninges

    Tumors of the Glia

    Group 1: 1. Astrocytoma. 2. Oligodendroglioma.

    Group 2: 1. Glioblastoma multiforme. 2. Spongioblastoma Polare. 3. Astroblastoma. 4. Medulloblastoma. 5. Neuro-epithelioma. 6. Medullo-epithelioma

    Tumors of the Neuron

    1. Ganglioneuroma

    2. Neuroblastoma

    Tumors of the Ependyma

    Tumors of the Choroidal Epithelium

    Tumors of the Blood Vessels

    Tumors of the Hypophysis

    Tumors of the Craniopharyngeal Duct

    Tumors of the Pineal Gland

    Tumors of the Nerves

    Tumors of the Spinal Cord


    Metastatic Tumors

    Chapter XIII. Congenitcal Malformations

    Cortical Malformation

    Tuberous Sclerosis

    Malformations of the Sheaths of the Central Nervous System

    Hydrocephalus Internus

    Little's Disease


    Tables 23-30

    Autopsy and Fixation of the Central Nervous System

    Staining Methods


    1. Axis-Cylinders

    2. Myelin Sheaths

    3. Nissl Bodies and Nuclei

    4. Connective Tissue

    5. Micro- and Oligodendroglia

    6. Astrocytes

    7. Microglia

    8. Glia Fibers

    9. Fat Stain

    10. Hematoxylin-Eosin Stain



Product details

  • No. of pages: 370
  • Language: English
  • Copyright: © Butterworth-Heinemann 1946
  • Published: January 1, 1946
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483225968

About the Author

Arthur Weil

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