Textbook of Neuropathology

Textbook of Neuropathology, Second Edition covers some of the significant advances in understanding the theoretical and experimental aspects of neuropathology. Neuropathology is the study of the nervous tissue in disease and the determination of deviations of its structures from the normal. This edition is composed of 13 chapters, and begins with the description of the chemical changes occurring in the cell through autolysis and fixation. The subsequent chapters are devoted to studies on better understanding of the vitamin deficiencies, the discovery of the sulfonamides and their contribution to the therapy of meningitis, and the different forms of shock treatment applied to selected cases of neurosis and psychosis. The remaining chapters explore the contribution of neuropathological investigation in various medical conditions, including anemic softening, arteriosclerosis, inflammation, infections, intoxications, injuries, degenerative diseases, tumors, and congenital malformations.
This book will be of use to neuropathologists and workers and researchers in the allied fields.

Preface to the First Edition

Preface to the Second Edition

Introduction

Chapter I. Changes through Autolysis and Fixation

Autolysis

Postmortem Infection

Action of Ferments

Fixation

Effect of Formalin Fixation

Effect of Alcohol Fixation

Corpora Amylacea and Amyloid Bodies

Chapter II. Diseases of the Neuron

Normal Variations and Postmortem Changes

Specific Reactions

Incrustations

Lipoids

Glycogen and Amyloid

Chapter III. The Glia and Its Pathology

Astrocytes

Oligodendroglia

Microglia

Degenerative (Regressive) Changes of Glia Cells

Chapter IV. Pathology of the Myelin Sheath and the Axis-Cylinder

Experimental Demyelinization

Degeneration of the Myelin Sheaths

Disease of the Axis-Cylinders

Regeneration of the Peripheral Nerves

Chapter V. Anemic Softening

The Oxygen Consumption of the Brain

Anoxemia

Etiology of Anemia

Anemic Softening of the Brain

Hemorrhagic Softening of the Brain

Brain Purpura

Chapter VI. Arteriosclerosis

Vascular Disease in Arteriosclerosis

Atherosclerosis

Arteriolosclerosis

Calcification of the Media

Arteriocapillary Fibrosis

Pathology of the Brain

Apoplexy

The Arteriosclerotic Brain

Arteriosclerosis of the Spinal Cord

Chapter VII. Inflammation

Definition

The Hemato-Encephalic Barrier

Chapter VIII. Infections

The Mode of Invasion of Micro-organisms

Classification of Infections

1. Meningo-Encephalitis

2. Metastatic or Embolic Disseminated Encephalitis

3. Diffuse Polio-Encephalitis

4. Disseminated Polio-Encephalitis

5. Disseminated Encephalitis with Demyelinization

6. Diffuse Perivenous Focal Encephalitis

Tissue Alterations Following Infection

Exudation and Proliferation

Meningitis

Acute Leptomeningitis

Chronic Leptomeningitis

Ependymitis

Epidemic Meningitis

Nonepidemic Forms of Purulent Meningitis

Infectious Encephalitis and Myelitis

Purulent Encephalitis and Brain Abscess

Purulent Myelitis

Acute Epidemic Encephalitis

Acute Poliomyelitis

Tuberculosis of the Central Nervous System

Tuberculous Meningitis

Tuberculoma

Pott's Disease

Syphilis of the Central Nervous System

Syphilitic Meningitis

Gumma

Syphilitic Meningo-Encephalitis

Syphilitic Meningomyelitis

Vascular Syphilis

General Paralysis

Tabes Dorsalis

Blastomyces Infections

Protozoal Infections

Acute Disseminated Encephalomyelitis

Disseminated Sclerosis

Diffuse Sclerosis

Chapter IX. Intoxications

Alcohol

Alkaloids and Narcotics

Lead and Arsenic

Insulin and Metrazol

Carbon Monoxide

Endogenous Intoxication

Meat Poisoning

Liver Disease

Uremia

Avitaminosis

Subacute Combined Degeneration

Chapter X. Injuries

The Brain

Concussion

Skull Fractures and Brain Wounds

The Spinal Cord

Concussion

Compression

The Peripheral Nerves

Effects of X Rays, Heat, and Electrical Current

Chapter XI. Degenerative Diseases

The Muscular Dystrophies

Dystrophia Musculorum

Dystrophia Myotonica

Myotonia Congenita

Myasthenia Gravis

The Amyotrophies

Progressive Neuropathic (Peroneal) Muscular Atrophy

Progressive Muscular Atrophies

Amyotrophic Lateral Sclerosis

The Heredofamilial Ataxias

Chorea

Chronic Progressive Chorea (Huntington)

Infectious Chorea

Parkinsonism

Familial Amaurotic Idiocy

Cerebral Cortical Degeneration

Senile Cortical Degeneration

Pick's Disease (Lobar Sclerosis)

Chapter XII. Tumors

Tumors of the Meninges

Tumors of the Glia

Group 1: 1. Astrocytoma. 2. Oligodendroglioma.

Group 2: 1. Glioblastoma multiforme. 2. Spongioblastoma Polare. 3. Astroblastoma. 4. Medulloblastoma. 5. Neuro-epithelioma. 6. Medullo-epithelioma

Tumors of the Neuron

1. Ganglioneuroma

2. Neuroblastoma

Tumors of the Ependyma

Tumors of the Choroidal Epithelium

Tumors of the Blood Vessels

Tumors of the Hypophysis

Tumors of the Craniopharyngeal Duct

Tumors of the Pineal Gland

Tumors of the Nerves

Tumors of the Spinal Cord

Syringomyelia

Metastatic Tumors

Chapter XIII. Congenitcal Malformations

Cortical Malformation

Tuberous Sclerosis

Malformations of the Sheaths of the Central Nervous System

Hydrocephalus Internus

Little's Disease

Appendix

Tables 23-30

Autopsy and Fixation of the Central Nervous System

Staining Methods

Embedding

1. Axis-Cylinders

2. Myelin Sheaths

3. Nissl Bodies and Nuclei

4. Connective Tissue

5. Micro- and Oligodendroglia

6. Astrocytes

7. Microglia

8. Glia Fibers

9. Fat Stain

10. Hematoxylin-Eosin Stain

Bibliography

Index