Textbook of Medicinal Chemistry Vol I - 1st Edition - ISBN: 9788131221891, 9788131232583

Textbook of Medicinal Chemistry Vol I

1st Edition

Authors: V Alagarsamy
Paperback ISBN: 9788131221891
eBook ISBN: 9788131232583
Imprint: Elsevier India
Published Date: 15th May 2009
Page Count: 620


Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharm. students, this book will also be useful for M. Pharm. as well as M. Sc. organic chemistry and pharmaceutical chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing enormous information on all the topics in medicinal chemistry of synthetic drugs.

Key Features

Salient Features

    • Contains clear classification, synthetic schemes, mode of action, metabolism, assay, pharmacological uses with the dose and structure–activity relationship (SAR) of the following classes of drugs:
      • Drugs acting on inflammation
      • Drugs acting on respiratory system
      • Drugs acting on digestive system
      • Drugs acting on blood and blood-forming organs
      • Drugs acting on endocrine system

    • Contains a complete section on chemotherapy and the various classes of chemotherapeutic agents. Also includes recent topics like anti-HIV agents
    • Contains brief introduction about the physiological and pathophysiological conditions of diseases and their treatment under each topic
    • Provides well-illustrated synthetic schemes and alternative synthetic routes for majority of drugs that help in quick and enhanced understanding of the subject
    • Covers the syllabi of majority of Indian universities

Table of Contents

Preface v

Acknowledgements vii

Introduction to Medicinal Chemistry

• Processes of Drug Discovery • Drug Discovery and Design—A

Historical Outline • Modern Drug Discovery • Screening and

Designing • Nature as a Source of Drug Compounds

• Drug Designing

SECTION I Physicochemical Factors in Relation to Biological Activity of Drugs 9

Chapter 1 Physicochemical Properties 11

Chapter 2 Ferguson Principle 13

Chapter 3 Hydrogen Bonding 15

Chapter 4 Ionization and pKa Value 19

Chapter 5 Redox Potential 22

Chapter 6 Surface Tension 25

Chapter 7 Complexation 27

Chapter 8 Steric Features of Drugs 30

Chapter 9 Bioisosterism 36

SECTION II Drug Design 41

Chapter 1 Concepts of Drug Design 43

• Design of Analogues and Pro-drugs

• Design of Lead and Lead Discovery • Rational

Approach to Drug Design

Chapter 2 Receptors 49

• Types of Receptors • Theories of Receptors

• Forces Involved in Drug Receptors Interaction • Factors

Affecting the Drug-Receptors Interaction

Chapter 3 Computer-Aided Drug Design 54

• Bioinformatics Hub

Chapter 4 Structure–Activity Relationship and

Quantitative Structure–Activity Relationship 56

• Historical Development of QSAR

• Basic Requirements for QSAR Analysis • Model

Development Procedures

Chapter 5 Combinatorial Chemistry 66

• Combinatorial Compound Libraries

Chapter 6 Pro-Drugs 71

• Classification of Pro-drugs • Application

of Pro-drugs

SECTION III Drugs Acting on Central Nervous System 83</STRONG


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© Elsevier India 2009
Elsevier India
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About the Author

V Alagarsamy