Textbook of Medicinal Chemistry Vol I

1st Edition


  • V Alagarsamy
    • Electronic ISBN 9788131232583

    Key Features

    Salient Features

      • Contains clear classification, synthetic schemes, mode of action, metabolism, assay, pharmacological uses with the dose and structure–activity relationship (SAR) of the following classes of drugs:
        • Drugs acting on inflammation
        • Drugs acting on respiratory system
        • Drugs acting on digestive system
        • Drugs acting on blood and blood-forming organs
        • Drugs acting on endocrine system

      • Contains a complete section on chemotherapy and the various classes of chemotherapeutic agents. Also includes recent topics like anti-HIV agents
      • Contains brief introduction about the physiological and pathophysiological conditions of diseases and their treatment under each topic
      • Provides well-illustrated synthetic schemes and alternative synthetic routes for majority of drugs that help in quick and enhanced understanding of the subject
      • Covers the syllabi of majority of Indian universities

    Table of Contents

    Preface v

    Acknowledgements vii

    Introduction to Medicinal Chemistry

    • Processes of Drug Discovery • Drug Discovery and Design—A

    Historical Outline • Modern Drug Discovery • Screening and

    Designing • Nature as a Source of Drug Compounds

    • Drug Designing

    SECTION I Physicochemical Factors in Relation to Biological Activity of Drugs 9

    Chapter 1 Physicochemical Properties 11

    Chapter 2 Ferguson Principle 13

    Chapter 3 Hydrogen Bonding 15

    Chapter 4 Ionization and pKa Value 19

    Chapter 5 Redox Potential 22

    Chapter 6 Surface Tension 25

    Chapter 7 Complexation 27

    Chapter 8 Steric Features of Drugs 30

    Chapter 9 Bioisosterism 36

    SECTION II Drug Design 41

    Chapter 1 Concepts of Drug Design 43

    • Design of Analogues and Pro-drugs

    • Design of Lead and Lead Discovery • Rational

    Approach to Drug Design

    Chapter 2 Receptors 49

    • Types of Receptors • Theories of Receptors

    • Forces Involved in Drug Receptors Interaction • Factors

    Affecting the Drug-Receptors Interaction

    Chapter 3 Computer-Aided Drug Design 54

    • Bioinformatics Hub

    Chapter 4 Structure–Activity Relationship and

    Quantitative Structure–Activity Relationship 56

    • Historical Development of QSAR

    • Basic Requirements for QSAR Analysis • Model

    Development Procedures

    Chapter 5 Combinatorial Chemistry 66

    • Combinatorial Compound Libraries

    Chapter 6 Pro-Drugs 71

    • Classification of Pro-drugs • Application

    of Pro-drugs

    SECTION III Drugs Acting on Central Nervous System 83


    No. of pages:
    © 2009
    Elsevier India
    Electronic ISBN: