Textbook of Medicinal Chemistry Vol I - 1st Edition - ISBN: 9788131221891, 9788131232583

Textbook of Medicinal Chemistry Vol I

1st Edition

Authors: V Alagarsamy
Paperback ISBN: 9788131221891
eBook ISBN: 9788131232583
Imprint: Elsevier India
Published Date: 25th October 2009
Page Count: 620

Description

Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharm. students, this book will also be useful for M. Pharm. as well as M. Sc. organic chemistry and pharmaceutical chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing enormous information on all the topics in medicinal chemistry of synthetic drugs.

Key Features

Salient Features

    • Contains clear classification, synthetic schemes, mode of action, metabolism, assay, pharmacological uses with the dose and structure–activity relationship (SAR) of the following classes of drugs:
      • Drugs acting on inflammation
      • Drugs acting on respiratory system
      • Drugs acting on digestive system
      • Drugs acting on blood and blood-forming organs
      • Drugs acting on endocrine system

    • Contains a complete section on chemotherapy and the various classes of chemotherapeutic agents. Also includes recent topics like anti-HIV agents
    • Contains brief introduction about the physiological and pathophysiological conditions of diseases and their treatment under each topic
    • Provides well-illustrated synthetic schemes and alternative synthetic routes for majority of drugs that help in quick and enhanced understanding of the subject
    • Covers the syllabi of majority of Indian universities

Table of Contents

Preface v

Acknowledgements vii

Introduction to Medicinal Chemistry

• Processes of Drug Discovery • Drug Discovery and Design—A

Historical Outline • Modern Drug Discovery • Screening and

Designing • Nature as a Source of Drug Compounds

• Drug Designing

SECTION I Physicochemical Factors in Relation to Biological Activity of Drugs 9

Chapter 1 Physicochemical Properties 11

Chapter 2 Ferguson Principle 13

Chapter 3 Hydrogen Bonding 15

Chapter 4 Ionization and pKa Value 19

Chapter 5 Redox Potential 22

Chapter 6 Surface Tension 25

Chapter 7 Complexation 27

Chapter 8 Steric Features of Drugs 30

Chapter 9 Bioisosterism 36

SECTION II Drug Design 41

Chapter 1 Concepts of Drug Design 43

• Design of Analogues and Pro-drugs

• Design of Lead and Lead Discovery • Rational

Approach to Drug Design

Chapter 2 Receptors 49

• Types of Receptors • Theories of Receptors

• Forces Involved in Drug Receptors Interaction • Factors

Affecting the Drug-Receptors Interaction

Chapter 3 Computer-Aided Drug Design 54

• Bioinformatics Hub

Chapter 4 Structure–Activity Relationship and

Quantitative Structure–Activity Relationship 56

• Historical Development of QSAR

• Basic Requirements for QSAR Analysis • Model

Development Procedures

Chapter 5 Combinatorial Chemistry 66

• Combinatorial Compound Libraries

Chapter 6 Pro-Drugs 71

• Classification of Pro-drugs • Application

of Pro-drugs

SECTION III Drugs Acting on Central Nervous System 83

Chapter 1 Central Nervous System 85

Chapter 2 Sedatives and Hypnotics 88

• Molecular Basis of Inhibitory

Neurotransmitters • Classification • Synthesis and

Drug Profile • SAR of Barbiturates; SAR of Benzodiazepines

Chapter 3 General Anaesthetics 130

• Stages of Anaesthesia • Classification

• Synthesis and Drug Profile

Chapter 4 Local Anaesthetics 150

• Classification • Synthesis and Drug

Profile • SAR of Benzoic Acid Derivatives • SAR of Anilides

Chapter 5 Tranquillizers 178

• General Mode of Action • Classification

• Synthesis and Drug Profile • SAR of Phenothiazines;

SAR of Butyrophenones

Chapter 6 Antidepressants 204

• Classification • Synthesis and Drug Profile

• SAR of Dibenzazepines; SAR of Dibenzocylcoheptane

Derivatives

Chapter 7 CNS Stimulants 229

• Classification • Synthesis and Drug Profile

Chapter 8 Narcotic Analgesics 247

• Synthesis and Drug Profile

• SAR of Morphine Derivatives; SAR of Meperidine Analogues;

SAR of Methadone Derivatives; SAR of Benzomorphan

Derivatives • Narcotic Antagonists • Classification

• Synthesis and Drug Profile

Chapter 9 Anticonvulsants 286

• Classification • Synthesis and Drug Profile

• SAR of Hydantoins; SAR of Oxazolidine Diones;

SAR of Phenacemide Analogues

Chapter 10 Anti-Prakinsonism Agents 317

• Classification • Synthesis and Drug Profile

Chapter 11 Skeletal Muscle Relaxants 329

• Classification • Synthesis and Drug Profile

Chapter 12 Alzheimer’s Disease 344

• Pathogenesis; Treatment

SECTION IV Drugs Acting on Autonomic Nervous System 349

Chapter 1 Autonomic Nervous System 351

Chapter 2 Adrenergic Drugs 356

• Physiological Basis of Adrenergic Receptors

Function • General Classification of Adrenergic Agonists

• Synthesis and Drug Profile • Structural–Activity Relationship

Chapter 3 Cholinergic Drugs 378

• Spectrum of Cholinomimetic Drugs

• Classification • Synthesis and Drug Profile • Structure–

Activity Relationship

Chapter 4 Andrenergic Blockers 398

• Physiological Basis of Adrenergic Receptor

Antagonists • Classification • Synthesis and Drug Profile

• Structure–Activity Relationship

Chapter 5 Anticholinergic Drugs 419

• Difference Between the Quaternary and

the Tertiary Antimuscarinics • Classification • Synthesis

and Drug Profile • SAR of Atropine Analogues; SAR of

Muscarinic Antagonists

SECTION V Drugs Acting on Cardiovascular System 445

Chapter 1 Cardiovascular System 447

Chapter 2 Antihypertensive Drugs 449

• Classification • Synthesis and Drug Profile

Chapter 3 Antiarrhythmic Drugs 476

• Classification • Synthesis and Drug Profile

Chapter 4 Antihyperlipidaemic Agents 499

• Classification • Synthesis and Drug Profile

Chapter 5 Antianginals 520

• Principles of Therapy for Angina

• Classification • Synthesis and Drug Profile • SAR of

Dihydropyridine Derivatives

SECTION VI Drugs Acting on Urinary System 547

Chapter 1 Urinary System 549

Chapter 2 Diuretics 551

• Classification • Synthesis and Drug Profile; SAR of Thiazide

Derivatives; SAR Carbonic Anhydrase Inhibitors; SAR of Loop

Diuretics

 

Details

No. of pages:
620
Language:
English
Copyright:
© Elsevier India 2009
Published:
Imprint:
Elsevier India
eBook ISBN:
9788131232583
Paperback ISBN:
9788131221891

About the Author

V Alagarsamy