Key Features

Salient Features

    • Contains clear classification, synthetic schemes, mode of action, metabolism, assay, pharmacological uses with the dose and structure–activity relationship (SAR) of the following classes of drugs:
      • Drugs acting on inflammation
      • Drugs acting on respiratory system
      • Drugs acting on digestive system
      • Drugs acting on blood and blood-forming organs
      • Drugs acting on endocrine system

    • Contains a complete section on chemotherapy and the various classes of chemotherapeutic agents. Also includes recent topics like anti-HIV agents
    • Contains brief introduction about the physiological and pathophysiological conditions of diseases and their treatment under each topic
    • Provides well-illustrated synthetic schemes and alternative synthetic routes for majority of drugs that help in quick and enhanced understanding of the subject
    • Covers the syllabi of majority of Indian universities

Table of Contents

Preface v

Acknowledgements vii

Introduction to Medicinal Chemistry

• Processes of Drug Discovery • Drug Discovery and Design—A

Historical Outline • Modern Drug Discovery • Screening and

Designing • Nature as a Source of Drug Compounds

• Drug Designing

SECTION I Physicochemical Factors in Relation to Biological Activity of Drugs 9

Chapter 1 Physicochemical Properties 11

Chapter 2 Ferguson Principle 13

Chapter 3 Hydrogen Bonding 15

Chapter 4 Ionization and pKa Value 19

Chapter 5 Redox Potential 22

Chapter 6 Surface Tension 25

Chapter 7 Complexation 27

Chapter 8 Steric Features of Drugs 30

Chapter 9 Bioisosterism 36

SECTION II Drug Design 41

Chapter 1 Concepts of Drug Design 43

• Design of Analogues and Pro-drugs

• Design of Lead and Lead Discovery • Rational

Approach to Drug Design

Chapter 2 Receptors 49

• Types of Receptors • Theories of Receptors

• Forces Involved in Drug Receptors Interaction • Factors

Affecting the Drug-Receptors Interaction

Chapter 3 Computer-Aided Drug Design 54

• Bioinformatics Hub

Chapter 4 Structure–Activity Relationship and

Quantitative Structure–Activity Relationship 56

• Historical Development of QSAR

• Basic Requirements for QSAR Analysis • Model

Development Procedures

Chapter 5 Combinatorial Chemistry 66

• Combinatorial Compound Libraries

Chapter 6 Pro-Drugs 71

• Classification of Pro-drugs • Application

of Pro-drugs

SECTION III Drugs Acting on Central Nervous System 83


No. of pages:
© 2009
Elsevier India
eBook ISBN:
Print ISBN:

About the author