Textbook of Medical Virology

Textbook of Medical Virology

1st Edition - March 30, 1983

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  • Editors: Erik Lycke, Erling Norrby
  • eBook ISBN: 9781483191942

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Textbook of Medical Virology presents a critical review of general principles in the field of medical virology. It discusses the description and molecular structures of virus. It addresses the morphology and classifications of viruses. It also demonstrates the principal aspects of virus particle structure. Some of the topics covered in the book are the symmetrical arrangements of viruses; introduction to different families of animal viruses; biochemistry of virus particles; the immunological properties and biological activities of viral gene products; description of enzymatic activities of viruses; and haemagglutination, cell fusion, and haemolysis of viruses. The description and characteristics of viral antigens are covered. The identification and propagation of viruses in tissue and cell cultures are discussed. An in-depth analysis of the principles of virus replication is provided. A study of the morphogenesis of virions is also presented. A chapter is devoted to virus-induced changes of cell structures and functions. The book can provide useful information to virologists, microbiologists, students, and researchers.

Table of Contents

  • 1 Viruses - A Unique Kind of Infectious Agent

    2 The Morphology of Virus Particles. Classification of Viruses

    Infectious Nucleic Acid

    Principal Aspects of Virus Particle Structure

    Live or Dead Materia?

    Structural Proteins - Symmetry Arrangements

    The Virus Envelope

    Classification of Viruses

    Introduction to Different Families of Animal Viruses

    3 The Biochemistry of Virus Particles



    Virus Proteins

    Additional Components in Virions

    4 Viral Gene Products; Their Immunological Properties and Biological Activities

    Viral Antigens


    Cell Fusion and Haemolysis

    Enzymatic Activities of Viral Gene Products

    5 Cultivation of Viruses

    Identification and Propagation of Viruses in Tissue and Cell Cultures

    Identification and Propagation of Viruses in Embryonated Hen's Eggs

    Identification and Cultivation of Viruses in Experimental Animals

    6 General Views on Virus Replication

    Morphological Methods for Analysis of Virus Replication

    Molecular Methods for Characterization of Virus Replication

    Quantitative Determination of Virus Infectivity

    Quantitative Determination of Other Biological Properties of Viral Products

    The Different Phases of Virus Replication

    7 Attachment of Viruses to Cell Receptors and Penetration of Viruses Into Cells

    Virus and Receptors


    8 Replication, Transcription and Translation of RNA Viruses

    Classes of RNA Viruses




    Rhabdoviruses and Paramyxoviruses



    9 Replication, Transcription and Translation of DNA Viruses






    10 The Morphogenesis of Virions

    The Maturation and Release of Non-Enveloped Viruses

    The Morphogenesis of Enveloped Viruses

    11 Virus-Induced Changes of Cell Structures and Functions

    Cytopathic Changes

    Inclusions in Virus-Infected Cells

    The Effect of Integration of Viral Antigens in Cellular Membranes

    Effects of Viruses on Functions of Highly Specialized Cells

    Chromosomal Changes

    Virus-Induced Cell Transformation


    12 Virus Genetics



    Phenotypic Mixing and Complementation

    13 General Aspects of Pathogenesis of Virus Infections

    Modes of Transmission of Virus Diseases

    The Importance of Cellular and Viral Receptor Functions

    The Spread of Virus Infections within The Body

    The Importance of Barrier Systems in Limiting the Spread of the Infection

    Influence of Immune Reactions On The Pathogenesis

    Influence of Constitution, Age, Sex and Genetic Background

    14 Pathogenesis of Acute Virus Infections

    Respiratory Infections

    Infections of Visceral Organs

    Infections of the Skin and Mucous Membranes

    Infections of the Nervous System

    15 The Pathogenesis of Congenital Infections

    Different Ways by Which a Virus May Cause Fetal Damage

    Spread of Virus in Congenital Infections

    Direct Effects of Fetal Infections

    Indirect Fetal-Damaging Effects in Connection with Infections of Pregnant Women

    16 The Pathogenesis of Persistent Infections

    Chronic Subclinical Infections with Immune Pathological Reactions

    Latent Infections

    Slow Virus Infections Caused by Conventional Viruses

    17 Slow Infections Caused by Non-Immunogenic Infectious Agents

    Different Forms of Infectious Encephalopathy

    Biological and Physical-Chemical Properties of Atypical Infectious Agents

    How do Atypical Infectious Agents Spread?

    18 Viruses and Tumors

    Tumor Viruses in Animals

    Human Tumor Viruses

    Human Tumor Virus Candidates

    19 Mechanisms of Defense Against Virus Infections

    Non-Specific Immunity

    Humoral Immunity

    Cell-Mediated Immunity

    Immunopathological Effects of Virus Infections

    Virus Infections in Connection with Malignant Diseases and Immune Suppression

    Immunological Defense Against Congenital Virus Infections

    20 Laboratory Techniques for Diagnosis of Virus Infections

    Isolation of Viruses

    Direct Identification of Virus or Viral Antigens in Samples from Patients

    Analysis of Antibody Response In Patients

    Evaluation of Laboratory Results

    21 The Epidemiology of Virus Diseases

    Methods of Surveillance of the Epidemiological Occurrence of Infectious Diseases

    The Dissemination Mechanisms of Virus Infections

    Epidemiological Patterns of Virus Infections

    Examples of the Epidemiology of Some Virus Diseases

    22 Inactivation of Viral Infectivity and Disinfection

    23 Immune Prophylaxis

    Passive Immunization

    Active Immunization

    24 Antiviral Drugs

    Mechanisms of Action of Antiviral Drugs

    Antiviral Drugs Used for Clinical Chemotherapy

    Antiviral Drugs with a Potential Clinical Usefulness


    25 Picornaviruses

    Properties of Picornaviruses



    26 Togaviruses



    Rubellavirus (Rubivirus)

    27 Orthomyxoviruses (Influenza Viruses)

    Properties of the Virus

    Clinical Features



    Laboratory Diagnosis


    28 Paramyxoviruses

    Parainfluenza Virus

    Mumps Virus

    Measles Virus

    Respiratory Syncytial (RS) Virus

    29 Adenoviruses

    Properties of the Virus

    Clinical Features



    30 Hepatitis Viruses

    Properties of the Virus

    Clinical Features



    Laboratory Diagnosis



    31 Herpesviruses

    Properties of the Virus

    Latency and Transformation

    Herpes Simplex Virus (HSV) Infections

    Varicella Zoster Virus (VZV) Infections

    Cytomegalovirus (CMV) Infections

    Epstein-Barr Virus (EBV) Infections

    32 Poxviruses


    Properties of the Virus

    Variola (Smallpox)

    Smallpox Vaccine (Vaccinia Virus)

    The WHO Smallpox Eradication Program

    Clinical Features of Variola

    Laboratory Diagnosis

    Other Medically Important Poxviruses

    33 Other Viruses






    Rhabdoviruses (Rabies Virus)

    Marburg/Ebola Virus



    34 Viral Syndromes

    Respiratory Tract Infections

    Infections of the Pharynx

    Infections with Exanthemas


    Gastrointestinal Infections

    Urogenital Infections

    Infections of the Nervous System

    Infections of the Sensory Organs

    Neonatal Infections

    Appendix. Chlamydia

    Microbiology of Chlamydiae

    Chlamydia Psittaci Infections

    Chlamydia Trachomatis Infections

    Laboratory Diagnosis

    Susceptibility of Chlamydiae to Antibiotics


Product details

  • No. of pages: 384
  • Language: English
  • Copyright: © Butterworth-Heinemann 1983
  • Published: March 30, 1983
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483191942

About the Editors

Erik Lycke

Erling Norrby

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