Textbook of Medical Virology - 1st Edition - ISBN: 9780407002531, 9781483191942

Textbook of Medical Virology

1st Edition

Editors: Erik Lycke Erling Norrby
eBook ISBN: 9781483191942
Imprint: Butterworth-Heinemann
Published Date: 30th March 1983
Page Count: 384
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Description

Textbook of Medical Virology presents a critical review of general principles in the field of medical virology. It discusses the description and molecular structures of virus. It addresses the morphology and classifications of viruses. It also demonstrates the principal aspects of virus particle structure. Some of the topics covered in the book are the symmetrical arrangements of viruses; introduction to different families of animal viruses; biochemistry of virus particles; the immunological properties and biological activities of viral gene products; description of enzymatic activities of viruses; and haemagglutination, cell fusion, and haemolysis of viruses. The description and characteristics of viral antigens are covered. The identification and propagation of viruses in tissue and cell cultures are discussed. An in-depth analysis of the principles of virus replication is provided. A study of the morphogenesis of virions is also presented. A chapter is devoted to virus-induced changes of cell structures and functions.
The book can provide useful information to virologists, microbiologists, students, and researchers.

Table of Contents


1 Viruses - A Unique Kind of Infectious Agent

2 The Morphology of Virus Particles. Classification of Viruses

Infectious Nucleic Acid

Principal Aspects of Virus Particle Structure

Live or Dead Materia?

Structural Proteins - Symmetry Arrangements

The Virus Envelope

Classification of Viruses

Introduction to Different Families of Animal Viruses

3 The Biochemistry of Virus Particles

Virus-DNA

Virus-RNA

Virus Proteins

Additional Components in Virions

4 Viral Gene Products; Their Immunological Properties and Biological Activities

Viral Antigens

Haemagglutination

Cell Fusion and Haemolysis

Enzymatic Activities of Viral Gene Products

5 Cultivation of Viruses

Identification and Propagation of Viruses in Tissue and Cell Cultures

Identification and Propagation of Viruses in Embryonated Hen's Eggs

Identification and Cultivation of Viruses in Experimental Animals

6 General Views on Virus Replication

Morphological Methods for Analysis of Virus Replication

Molecular Methods for Characterization of Virus Replication

Quantitative Determination of Virus Infectivity

Quantitative Determination of Other Biological Properties of Viral Products

The Different Phases of Virus Replication

7 Attachment of Viruses to Cell Receptors and Penetration of Viruses Into Cells

Virus and Receptors

Penetration

8 Replication, Transcription and Translation of RNA Viruses

Classes of RNA Viruses

Reoviruses

Picornaviruses

Togaviruses

Rhabdoviruses and Paramyxoviruses

Orthomyxoviruses

Retroviruses

9 Replication, Transcription and Translation of DNA Viruses

Parvoviruses

Papovaviruses

Adenoviruses

Herpesviruses

Poxviruses

10 The Morphogenesis of Virions

The Maturation and Release of Non-Enveloped Viruses

The Morphogenesis of Enveloped Viruses

11 Virus-Induced Changes of Cell Structures and Functions

Cytopathic Changes

Inclusions in Virus-Infected Cells

The Effect of Integration of Viral Antigens in Cellular Membranes

Effects of Viruses on Functions of Highly Specialized Cells

Chromosomal Changes

Virus-Induced Cell Transformation

Interferon

12 Virus Genetics

Mutations

Recombination

Phenotypic Mixing and Complementation

13 General Aspects of Pathogenesis of Virus Infections

Modes of Transmission of Virus Diseases

The Importance of Cellular and Viral Receptor Functions

The Spread of Virus Infections within The Body

The Importance of Barrier Systems in Limiting the Spread of the Infection

Influence of Immune Reactions On The Pathogenesis

Influence of Constitution, Age, Sex and Genetic Background

14 Pathogenesis of Acute Virus Infections

Respiratory Infections

Infections of Visceral Organs

Infections of the Skin and Mucous Membranes

Infections of the Nervous System

15 The Pathogenesis of Congenital Infections

Different Ways by Which a Virus May Cause Fetal Damage

Spread of Virus in Congenital Infections

Direct Effects of Fetal Infections

Indirect Fetal-Damaging Effects in Connection with Infections of Pregnant Women

16 The Pathogenesis of Persistent Infections

Chronic Subclinical Infections with Immune Pathological Reactions

Latent Infections

Slow Virus Infections Caused by Conventional Viruses

17 Slow Infections Caused by Non-Immunogenic Infectious Agents

Different Forms of Infectious Encephalopathy

Biological and Physical-Chemical Properties of Atypical Infectious Agents

How do Atypical Infectious Agents Spread?

18 Viruses and Tumors

Tumor Viruses in Animals

Human Tumor Viruses

Human Tumor Virus Candidates

19 Mechanisms of Defense Against Virus Infections

Non-Specific Immunity

Humoral Immunity

Cell-Mediated Immunity

Immunopathological Effects of Virus Infections

Virus Infections in Connection with Malignant Diseases and Immune Suppression

Immunological Defense Against Congenital Virus Infections

20 Laboratory Techniques for Diagnosis of Virus Infections

Isolation of Viruses

Direct Identification of Virus or Viral Antigens in Samples from Patients

Analysis of Antibody Response In Patients

Evaluation of Laboratory Results

21 The Epidemiology of Virus Diseases

Methods of Surveillance of the Epidemiological Occurrence of Infectious Diseases

The Dissemination Mechanisms of Virus Infections

Epidemiological Patterns of Virus Infections

Examples of the Epidemiology of Some Virus Diseases

22 Inactivation of Viral Infectivity and Disinfection

23 Immune Prophylaxis

Passive Immunization

Active Immunization

24 Antiviral Drugs

Mechanisms of Action of Antiviral Drugs

Antiviral Drugs Used for Clinical Chemotherapy

Antiviral Drugs with a Potential Clinical Usefulness

Interferon

25 Picornaviruses

Properties of Picornaviruses

Enteroviruses

Rhinoviruses

26 Togaviruses

Alphaviruses

Flaviviruses

Rubellavirus (Rubivirus)

27 Orthomyxoviruses (Influenza Viruses)

Properties of the Virus

Clinical Features

Pathogenesis

Epidemiology

Laboratory Diagnosis

Prophylaxis

28 Paramyxoviruses

Parainfluenza Virus

Mumps Virus

Measles Virus

Respiratory Syncytial (RS) Virus

29 Adenoviruses

Properties of the Virus

Clinical Features

Epidemiology

Prophylaxis

30 Hepatitis Viruses

Properties of the Virus

Clinical Features

Pathogenesis

Immunity

Laboratory Diagnosis

Epidemiology

Prophylaxis

31 Herpesviruses

Properties of the Virus

Latency and Transformation

Herpes Simplex Virus (HSV) Infections

Varicella Zoster Virus (VZV) Infections

Cytomegalovirus (CMV) Infections

Epstein-Barr Virus (EBV) Infections

32 Poxviruses

Classification

Properties of the Virus

Variola (Smallpox)

Smallpox Vaccine (Vaccinia Virus)

The WHO Smallpox Eradication Program

Clinical Features of Variola

Laboratory Diagnosis

Other Medically Important Poxviruses

33 Other Viruses

Reoviruses

Retroviruses

Bunyaviruses

Arenaviruses

Coronaviruses

Rhabdoviruses (Rabies Virus)

Marburg/Ebola Virus

Parvoviruses

Papovaviruses

34 Viral Syndromes

Respiratory Tract Infections

Infections of the Pharynx

Infections with Exanthemas

Hepatitis

Gastrointestinal Infections

Urogenital Infections

Infections of the Nervous System

Infections of the Sensory Organs

Neonatal Infections

Appendix. Chlamydia

Microbiology of Chlamydiae

Chlamydia Psittaci Infections

Chlamydia Trachomatis Infections

Laboratory Diagnosis

Susceptibility of Chlamydiae to Antibiotics

Index


Details

No. of pages:
384
Language:
English
Copyright:
© Butterworth-Heinemann 1983
Published:
Imprint:
Butterworth-Heinemann
eBook ISBN:
9781483191942

About the Editor

Erik Lycke

Erling Norrby

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