COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
α-Tertiary Amines en Route to Natural Products - 1st Edition - ISBN: 9780128222621

α-Tertiary Amines en Route to Natural Products

1st Edition

0.0 star rating Write a review
Authors: Abdul Hameed Mariya Al-Rashida Muhammad Raza Shah
Paperback ISBN: 9780128222621
Imprint: Elsevier
Published Date: 1st January 2021
Page Count: 242
Sales tax will be calculated at check-out Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Description

α-Tertiary Amines en Route to Natural Products presents the multistep synthesis of natural products using schematic diagrams. This approach provides a quick-and-easy way to review and understand new and novel synthetic strategies to construct structural frameworks of natural products. The book covers the class of natural products bearing the α,α-disubstituted α-amino acid motif. Featured natural product molecules include Altemicidin, Amathaspiramide (A-F), Kaitocephalin, Lactacystin, Salinosporamide, Manzacidins (A,C), Neooxazolomycin, Sphingofungins (E,F), (1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid (ACPD), Total synthesis of cephalotaxine and related molecules, α-amino acids based natural products, α amino acid based natural products and Tetrodotoxin.

This book is ideal for chemists working in the area of organic synthesis, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis.

Key Features

  • Outlines synthetic strategies for natural products bearing α-tertiary amines and α,α-disubstituted α-amino acid motif
  • Describes multistep synthetic routes that highlight key steps
  • Covers asymmetric and diastereoselective synthetic approaches towards targeted natural products
  • Illustrates multistep synthetic routes related to -amino acids based natural products and -amino acids based natural products

Readership

Researchers working in the area of organic synthesis and natural products, especially those who are involved in the development of new, efficient and novel methodologies for natural product synthesis

Table of Contents

1. Introduction: α,α-Disubsituted α-Amino Acids
2. Altemicidin
3. Amathaspiramide(A-F)
4. Kaitocephalin
5. Lactacystin
6. Salinosporamide
7. Manzacidins (A, C)
8. Sphingofungins (E, F) Synthesis
9. ACPD ((1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid)
10. Miscellaneous alkaloids: (+)-LY35470, Piperidine based alkaloids and Tetrodotoxin
11. Introduction: α,α-Disubsituted α-Amino Acids
12. Altemicidin
13. Amathaspiramide(A-F)
14. Kaitocephalin
15. Lactacystin
16. Salinosporamide
17. Manzacidins (A, C)
18. Sphingofungins (E, F) Synthesis
19. ACPD ((1S,3R)-1-Aminocyclopentane-1,3-diarboxylic Acid)
20. Miscellaneous alkaloids: (+)-LY35470, Piperidine based alkaloids and Tetrodotoxin

Details

No. of pages:
242
Language:
English
Copyright:
© Elsevier 2021
Published:
1st January 2021
Imprint:
Elsevier
Paperback ISBN:
9780128222621

About the Authors

Abdul Hameed

Dr. Abdul Hameed completed his PhD in Organic Chemistry from The University of Nottingham, UK. He worked in the area of natural products synthesis. He was a post-doc fellow at Max-Planck Institut für Polymerforschung, Germany in synthetic division headed by Prof. Dr. Klaus Müllen. He worked on the functionalization of adenylyl cyclsase inhibitors via chemical methods to conjugate them with monoclonal antibody to study their biological potential in Regulatory T cells (Treg). He is also the recipient of Gold Medal (2017/18) for Scientists under 40 in the Field of Chemistry by The Chemical Society of Pakistan. His current research interests are including the development of novel methodologies, their utilization in natural products synthesis, the synthesis heterocyclic compound compounds to evaluate their biological potential.

Affiliations and Expertise

H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Mariya Al-Rashida

Dr. Mariya al-Rashida is a synthetic chemist and has expertise in the area of organic synthesis. She completed Ph.D. in chemistry from the Institute of Chemistry, University of the Punjab, Lahore, Pakistan in 2011. Her area of expertise is synthetic and computational medicinal chemistry. She is currently working towards the synthesis of metalloenzyme inhibitors (carbonic anhydrase, and ecto-nucleotidases). She is an Associate Professor and Chairperson of the Department of Chemistry, Forman Christian College (A Chartered University), Lahore, Pakistan. She has published more than 60 research articles with a cumulative Impact Factor > 150 in various peer review international journals. She has been the recipient of many awards including the prestigious CSP Gold Medal Award for Chemist Under 40.

Affiliations and Expertise

Department of Chemistry, Forman Christian College, Lahore, Pakistan

Muhammad Raza Shah

Muhammad Raza Shah is Full Professor at the International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University of Karachi, Pakistan. He is also the Head of the Center for Bioequivalence Studies and Clinical Research (CBSCR) and the recipient of numerous awards, including the civil award Tamgha-i-Imtiaz from the President of Pakistan, Salam prize, Prof. Atta ur Rahman gold medal and the Dr. M. Raziuddin Siddiqi Prize (2015) for Scientists under 40 in the Field of Chemistry by the Pakistan Academy of Sciences. He was selected TWAS Young Affiliate in 2010 by Third World Academy of Sciences. He has authored three books (Elsevier) and also edited two books (Elsevier) in addition contributing over 350 peer-reviewed journal papers with impact factor more than 820. One of his authored books was declared best book of year 2017 by Government of Pakistan, Higher Education Commission. He is fellow International Union of Pure and Applied Chemistry and Fellow the Chemical Society of Pakistan. He is editor the Journal of the Chemical Society of Pakistan. He is mentor of Pakistani International Chemistry Olympiad team since 2009. He is also member of National Nanotechnology Foresight Committee constituted by PCST. He remained a member of COMSTECH consultative working group of scientists from OIC countries, to prepare agenda and action plan for the Ten-Year Plan of Action (TYPOA 2016-2025).

Affiliations and Expertise

Full Professor, International Center for Chemical and Biological Sciences, H.E.J. Research Institute of Chemistry University, Karachi, Pakistan

Ratings and Reviews