Telomeres in Health and Disease, Volume 125

• Preface
• Chapter One: Telomere and Telomerase Biology
  • Abstract
  • 1 Introduction
  • 2 The General Structure of Telomeric DNA
  • 3 Replication of Telomeres
  • 4 Telomeric Chromatin: Implications for End Protection, Telomere Replication, and Telomere Length Regulation
  • 5 TERRA: The Telomeric RNA Transcript
  • 6 Consequences of Telomere Deprotection
  • Acknowledgments
• Chapter Two: Human Telomeres and Telomere Biology Disorders
  • Abstract
  • 1 Introduction
  • 2 Telomere Biology in Humans
  • 3 What Is a TBD?
  • 4 Clinical Features of the TBDs
  • 5 Germ-Line Genetics of TBDs
  • 6 Diagnosing TBDs
  • 7 Genetic Counseling Considerations
  • 8 Clinical Management
  • 9 Summary and Future Directions
  • Acknowledgments
• Chapter Three: Telomere Biology in Stem Cells and Reprogramming
  • Abstract
  • 1 Introduction
  • 2 Telomere Homeostasis in Stem Cells
  • 3 Cellular Reprogramming
  • 4 Conclusions
• Chapter Four: Telomere Dynamics and Aging
  • Abstract
  • 1 Introduction: Telomere Structure, Determinants of Telomere Dynamics, Measurement Parameters, and Regulation Mechanisms
  • 2 Telomere Connection to the Characteristics of Aging: Cell Senescence and Apoptosis, Mitochondrial Function, and Metabolism
  • 3 Telomeres Dynamics in Early Embryonic Development, Stem Cells, and Infancy
  • 4 Telomere Dynamics and Aging-Related Disorders
  • 5 Perspective
  • Acknowledgments
• Chapter Five: Telomeres in Molecular Epidemiology Studies
  • Abstract
  • 1 Introduction
  • 2 TL in Accessible Tissue as a Surrogate for the Disease Site
  • 3 Considerations in Observational Studies of TL
  • 4 Epidemiological Evaluation of the Role of Telomeres in Human Health
  • 5 The Effect of TL Method of Measurement on Study Results
  • 6 Analytic Considerations in TL Epidemiology Studies
  • 7 Conclusions
  • Acknowledgment
• Chapter Six: Telomere Dysfunction and Hematologic Disorders
  • Abstract
  • 1 Introduction
  • 2 Bone Marrow Failure
  • 3 Dyskeratosis Congenita
  • 4 Disease Anticipation
  • 5 Aplastic Anemia
  • 6 Clinical Management in Bone Marrow Failure Syndromes
  • 7 Telomere Shortening in Other Bone Marrow Failure Syndromes
  • 8 Animal Models
  • 9 Telomeres and Hematologic Cancers
• Chapter Seven: The Role of Telomeres in Liver Disease
  • Abstract
  • 1 Telomeres and Telomerase, an Overview
  • 2 Telomere Shortening and Disease Progression
  • 3 The Role of Telomere Dysfunction in Cirrhosis Formation
  • 4 Association of Telomerase Mutations With Liver Cirrhosis
  • 5 The Role of Telomeres in Metabolic Liver Disease
  • 6 The Role of Telomeres During Carcinogenesis
  • 7 Chromosomal Instability and Hepatocarcinogenesis
  • 8 Telomere Dysfunction Promotes Hepatocarcinogenesis
  • 9 Conclusion
  • Conflict of Interests
• Chapter Eight: Telomeres in Lung Diseases
  • Abstract
  • 1 Introduction
  • 2 Idiopathic Pulmonary Fibrosis
  • 3 Telomeres and Emphysema
  • 4 Telomeres and Development of Lung Disease
  • 5 Conclusions
• Index

This special volume of Progress in Molecular Biology and Translational Science focuses on telomeres in health and disease. This volume covers a variety of topics with reviews written by experts in the field.

• Contributions from specialists in telomere diseases
• Informs and updates on how telomere dysfunction may cause disease in humans

PhDs in the fields of molecular and cellular biology and MDs and physician-scientists in internal medicine, hematology, oncology, pulmonology, and gastroenterology.