Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models.
Gives understanding of cancer biology that is appropriate for students and researchers in engineering and nanotechnology
Demonstrates cancer targeting strategies of multifunctional nanotechnology-based imaging probes
Shows how to design, synthesize and apply cancer imaging nanostructures
Researchers and students in diagnostic imaging, nanomedicine technology, biotechnology, biomedical engineering, cancer biology, molecular biology, epigenetics, oncology
Table of Contents
2. Passive Targeting 2.1 Enhanced permeability and retention effect
3. Active targeting 3.1 Tumor Microenvironment Targeting 3.1.1 Hypoxia Targeting 3.1.2 pH targeting 3.1.3 Matrix Metalloproteinase Targeting 3.1.4 Fibronectin Targeting 3.1.5 Apoptosis targeting 3.2 Vasculature Targeting 3.2.1 VEGF Targeting 3.2.2 Integrin Targeting 3.2.3 Vascular cell adhesion molecule- 1 targeting 3.3 Cancer Cell Surface Marker Targeting 3.3.1 Transferrin Receptor Targeting 3.3.2 Folate Receptor Targeting 3.3.3 EGFR Targeting 3.3.4 Glucose Transporter Targeting 3.3.5 Cathepsin Targeting 3.4 tumor type-specific targeting 3.4.1 targeted breast cancer imaging 3.4.2 targeted lung cancer imaging 3.4.3 Targeted Colorectal Cancer Imaging 3.4.4 Targeted Prostate Cancer Imaging 3.4.5 Targeted pancreatic Cancer Imaging 3.4.6 Targeted Bladder Cancer Imaging 3.4.7 Targeted Brain Cancer Imaging 3.4.8 Targeted Ovarian Cancer Imaging
4 Tumor-Specific Imaging Probes in Clinical Trials
Mehdi Azizi obtained his B.Sc. (Chemistry) from Razi University, Iran in 2012, and M.Sc. (Medical Nanotechnology) from Tehran University of Medical Sciences, Iran in 2016. He is currently a Ph.D. candidate in the Medical Nanotechnology department at Tabriz University of Medical Sciences, and working with Dr. Mohammad Mehrmohammadi group at biomedical imaging department of Wayne state University. His current research include synthesis, development and application of smart theranostic nanoplatforms.Mehdi Azizi obtained his B.Sc. (Chemistry) from Razi University, Iran in 2012, and M.Sc. (Medical Nanotechnology) from Tehran University of Medical Sciences, Iran in 2016. He is currently a Ph.D. candidate in the Medical Nanotechnology department at Tabriz University of Medical Sciences, and working with Dr. Mohammad Mehrmohammadi group at biomedical imaging department of Wayne state University. His current research include synthesis, development and application of smart theranostic nanoplatforms.
Affiliations and Expertise
Ph.D. candidate, Medical Nanotechnology Department, Tabriz University of Medical Sciences, Tabriz, Iran
Hadi Kokabi graduated in 2013 from Hamadan University School of Dentistry in Hamadan Iran. He completed his Postgraduate Periodontal Residency in 2018 at Tabriz University School of Dentistry in Tabriz, Iran. He is currently Assistant professor in Department of Periodontology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran. His current research include oral health, biomaterial and Nanobiomaterials in Clinical Dentistry
Affiliations and Expertise
Assistant professor, Department of Periodontology, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
Hassan Dianat-Moghadam received his B.Sc. degree in Medical Laboratory Sciences from the Shiraz University of Medical Sciences, Shiraz, Iran, M.Sc. in Medical Biotechnology from the Tehran University of Medical Sciences, Tehran, Iran, and Ph.D. in Medical Biotechnology from the Tabriz University of Medical Sciences, Tabriz, Iran.
Mohammad Mehrmohammadi is an assistant professor of Biomedical/Electrical and Computer Engineering at Wayne State University. He received his B.Sc. degree in Electrical Engineering from Sharif University of Technology (Tehran, Iran), the M.Sc. in Electrical and Computer Engineering from Illinois Institute of Technology (Chicago, IL), and the Ph.D. in Biomedical Engineering from the University of Texas at Austin (Austin, TX). His doctoral research at Ultrasound Imaging and Therapeutics Laboratory at UT Austin was focused on design and development of novel ultrasound-based molecular imaging. Prior to joining WSU, Mohammad worked at Mayo Clinic College of Medicine (Rochester, Minnesota) as a Senior Research Fellow where his research was mostly focused on development and clinical evaluation of various ultrasound-based tissue elastography methods for applications such as bladder poor compliance diagnosis, and thyroid and breast cancer. Mohammad is the recipient a number of awards such as DOD breakthrough award (Breast Cancer Program - 2017), College of Engineering excellence in teaching award (2017), and Karmanos Cancer Institute pilot research grant (2017). Mohammad is a member of editorial board for a number of a number of journals including Ultrasound in Medicine and Biology and Medical Physics and serves a technical committee member
for Acoustical Society of America (ASA) and SPIE Medical Imaging conferences. He is a member of institute of Electrical and Electronics Engineers (IEEE, UFFC and EMBS society), International Society for Optical Engineering (SPIE), World Molecular Imaging Society (WMIS), American Association for Cancer Research (AACR) and Sigma Xi.
Affiliations and Expertise
Assistant Professor of Biomedical/Electrical and Computer Engineering, Wayne State University, Michigan, USA