Target Validation in Drug Discovery

1st Edition

Editors: Brian Metcalf Susan Dillon
Hardcover ISBN: 9780123693938
eBook ISBN: 9780080465975
Imprint: Academic Press
Published Date: 22nd September 2006
Page Count: 296
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Description

This work presents a comprehensive contemporary framework for approaching target validation in drug discovery. It begins with a detailed description of new enabling technologies, including aptamers, RNA interference, functional genomics, and proteomics. The next section looks at biologic drug development with in-depth discussion of lessons learned from such well-known cases as Erbitux, Herceptin, and Avastin. Additional targets known as "second generation" drugs, which can be identified when disease pathways are validated by biologics, present new possible small molecule therapeutics and serve as the focus of the final section of the book.

Readership

Professionals in biotechnology and pharmaceutical drug discovery and clinical development. Can also include students and academics in the related areas of study.

Table of Contents

Section Contents I. Pharmaceutical Biotechnology for Target Validation II. Target Validation for Biopharmaceutical Drug Discovery III. Validating Targets of Small Molecule Approaches

Details

No. of pages:
296
Language:
English
Copyright:
© Academic Press 2007
Published:
Imprint:
Academic Press
eBook ISBN:
9780080465975
Hardcover ISBN:
9780123693938

About the Editor

Brian Metcalf

Affiliations and Expertise

Chief Drug Discovery Officer, Incyte Corporation, Moraga, CA, U.S.A.

Susan Dillon

Affiliations and Expertise

Senior Vice President, Discovery Research Centocor, Johnson & Johnson, Malvern, PA, U.S.A.