Systems of Nanovesicular Drug Delivery

1st Edition - July 16, 2022
Editors: Amit Kumar Nayak, Md Saquib Hasnain, Tejraj M. Aminabhavi, Vladimir P. Torchilin
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 8 6 4 - 0
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 4 2 2 - 2

Systems of Nanovesicular Drug Delivery provides a thorough insight into the complete and up-to-date discussions about the preparation, properties and drug delivery applicati… Read more

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Systems of Nanovesicular Drug Delivery provides a thorough insight into the complete and up-to-date discussions about the preparation, properties and drug delivery applications of various nanovesicles. This volume discusses cubosomes, proniosomes and niosomes, dendrimerosomes and other new and effective approaches for drug delivery. It will be a valuable title and resource for academics and pharmaceutical scientists, including industrial pharmacists, analytical scientists, health care professionals and regulatory scientists actively involved in pharmaceutical products and process development of tailor-made polysaccharides in drug delivery applications.

Recently, there have been a number of outstanding nanosystems in nanovesicular carrier-forms (such as nanoemulsions, self-nanoemulsifying systems, nanoliposomes, nanotransferosomes, etc.), that have been researched and developed for efficient drug delivery by many formulators, researchers and scientists. However, no previously published books have covered all these drug delivery nanovesicles collectively in a single resource.

Cover image
Title page
Table of Contents
Copyright
List of contributors
Preface
Chapter 1. Nanovesicular systems in drug delivery
Abstract
1.1 Introduction
1.2 An overview of various nanovesicles currently available in the literature
1.3 Preparation of nanovesicles
1.4 Drug delivery applications of nanovesicles
1.5 Future challenges of nanovesicles
1.6 Conclusions and future prospects
References
Chapter 2. Nanoemulsions for drug delivery
Abstract
2.1 Introduction
2.2 Preparation and characterization methods of nanoemulsions
2.3 Practical applications of nanoemulsions
2.4 Advantages, disadvantages and challenges of nanoemulsions
2.5 Conclusions
References
Chapter 3. Lipid-based nanocarriers for drug delivery: microemulsions versus nanoemulsions
Abstract
3.1 Introduction
3.2 Drug delivery systems based on nano-sized emulsions
3.3 Nanoemulsions versus nicroemulsions: a big discussion
3.4 Conclusion
Conflict of Interest
Acknowledgements
References
Chapter 4. Self-nanoemulsifying systems for delivery of drugs
Abstract
4.1 Introduction
4.2 General composition of the self-nanoemulsifying drug delivery systems
4.3 Method of preparation of self-nanoemulsifying drug delivery systems
4.4 Optimization of self-nanoemulsifying drug delivery system’s formulation
4.5 Characterization of self-nanoemulsifying drug delivery systems
4.6 Advancements in self-nanoemulsifying drug delivery systems
4.7 Application of self-nanoemulsifying drug delivery systems and supersaturated self-nanoemulsifying drug delivery systems
4.8 Self-nanoemulsifying drug delivery system formulations in the market
References
Chapter 5. Liposomes as efficient lipid nanovesicular systems for drug delivery
Abstract
5.1 Introduction
5.2 Liposomes and their classifications
5.3 Preparation of liposomes
5.4 Drug delivery applications of liposomes
5.5 Marketed liposomes
5.6 Conclusion
References
Chapter 6. Functionalized liposomes: a nanovesicular system
Abstract
6.1 Introduction
6.2 PEGylated liposomes (stealth liposomes)
6.3 Peptide-functionalized liposomes
6.4 Liposomes functionalized with antibody
6.5 Liposomes functionalized with small molecules
6.6 Nucleic acid-ligand or aptamers functionalized liposomes (aptamosomes)
6.7 Vitamin-functionalized liposomes
6.8 Protein-functionalized liposomes
6.9 Theranostic liposomes
6.10 Enzyme-functionalized liposomes (enzymosomes)
6.11 Conclusion
References
Chapter 7. Transferosomes: a novel nanovesicular approach for drug delivery
Abstract
7.1 Introduction
7.2 Transfersomes as drug delivery carriers
7.3 Mechanism of skin permeation by transferosomes
7.4 Formulation additives of transfersomes
7.5 Factors affecting properties of transfersomes
7.6 Methods of transfersomes’ preparations
7.7 Transfersomes under clinical trials
7.8 Marketed transferosomes
7.9 Conclusion
References
Chapter 8. Proniosomes and niosomes for enhanced drug delivery
Abstract
8.1 Introduction
8.2 Methods of preparation and considerations
8.3 Characterization of niosomes and proniosomes
8.4 Application and administration routes of niosomes and proniosomes
8.5 Sensitive and stealthy niosomes
8.6 Niosomes and proniosomes: a comparative scheme
8.7 Conclusion
Conflict of interest
Acknowledgements
References
Chapter 9. Cubosomes: a promising vesicular system for drug delivery
Abstract
9.1 Introduction
9.2 Cubosomes as versatile nanovesicle carriers for therapeutics
9.3 At the frontier of cubosomal delivery systems
9.4 Conclusions and future prospects
Acknowledgments
References
Chapter 10. Exosomes: a novel vesicular drug delivery platform
Abstract
10.1 Introduction
10.2 Exosomes
10.3 Biological functions of exosomes
10.4 Use of exosomes as drug delivery systems via transfer of cargoes
10.5 Therapeutic applications of exosomes as drug delivery systems
10.6 Conclusion
References
Chapter 11. Polymersomes as versatile drug delivery vesicular carriers
Abstract
11.1 Introduction
11.2 Synthesis of block copolymers and techniques for self-assembly of synthetic amphiphiles in polymersomes
11.3 Analytical techniques for the assessment of block copolymers and polymersomes
11.4 Modeling techniques for phenomena of molecular organization in micelles and vesicles
11.5 Case studies for drug delivery with polymersomes
Notation and abbreviations
Acknowledgements
References
Chapter 12. Aquasomes: a novel platform for drug delivery
Abstract
12.1 Introduction
12.2 Composition of aquasomes
12.3 Preparation of aquasomes
12.4 Characterization of aquasomes
12.5 Stability of aquasomes
12.6 Administration and application of aquasomes
12.7 Advantages of aquasomes
12.8 Limitations of aquasomes
12.9 Future perspectives
12.10 Conclusion
References
Chapter 13. Aquasomes: a nanoparticulate approach for therapeutic applications
Abstract
13.1 Introduction
13.2 Composition of aquasomes and role of each component
13.3 Role of self-assembly in aquasomes
13.4 Preparation technique of aquasomes
13.5 Characterization of aquasome
13.6 Applications of aquasomes
13.7 Challenges
13.8 Future possibilities and regulatory considerations
13.9 Conclusion
References
Chapter 14. Ethosomes: a potential vesicular carrier for drug delivery
Abstract
14.1 Introduction
14.2 Advantages and disadvantages of ethosomes
14.3 Mechanism of skin permeation by ethosomes
14.4 Method of preparation
14.5 Characterization of ethosomes
14.6 Application of ethosomes
References
Chapter 15. Nanophytosomes: a novel approach for the delivery of herbal drugs
Abstract
15.1 Introduction
15.2 Plant bioactive compounds and factors affecting their absorption and bioavailability
15.3 Delivery systems as strategies to improve natural products bioavailability
15.4 Phytosomes as delivery systems for phytochemicals
15.5 Conclusions
Acknowledgments
References
Chapter 16. Hyalurosomes: a newer approach for drug delivery
Abstract
16.1 Introduction
16.2 Obtaining hyalurosomes and liposomes
16.3 Hyaluronic acid-CD44 interactions
16.4 Hyalurosomes as dermal and topical drug delivery systems
16.5 Hyalurosomes as anti-inflammatory drug delivery systems
16.6 Hyalurosomes in cancer treatment
16.7 Dual mechanisms of hyaluronic acid-modified liposomes in cancer treatment
16.8 Concluding remarks
References
Chapter 17. Glycerosomes: a new tool for effective drug delivery
Abstract
17.1 Introduction
17.2 Effect of excipients on critical quality attributes
17.3 Effect on morphology
17.4 Glycerosomes as carrier for drug delivery
17.5 Conclusion
References
Chapter 18. Bilosomes: a novel platform for drug delivery
Abstract
18.1 Introduction
18.2 Material used for the preparation of bilosomes
18.3 Procedures for preparation of bilosomes
18.4 Characterization of bilosomes
18.5 Mechanisms of drug absorption enhancement
18.6 Factors affecting performance of bilosomes
18.7 Surface engineering of bilosomes
18.8 Features of bilosomes
18.9 Deficiencies of bilosomes
18.10 Applications of bilosomes
18.11 Concluding remarks
References
Chapter 19. Dendrimers and dendrimersomes as a novel tool for effective drug delivery applications
Abstract
19.1 Introduction
19.2 Synthesis of dendrimers and metallodendrimers
19.3 Synthesis of dendrimersomes
19.4 Drug delivery applications of dendrimers and dendrimersomes
19.5 Dendrimers and dendrimersomes: advantages, limitations, and future prospects
19.6 Conclusions
References
Chapter 20. Nanobubbles to aid drug delivery
Abstract
20.1 Introduction
20.2 Composition of nanobubbles
20.3 Stability and factors affecting the stability of nanobubbles
20.4 Preparation of nanobubbles
20.5 Applications of nanobubbles
20.6 Summary
References
Chapter 21. Nanospanlastic as a promising nanovesicle for drug delivery
Abstract
21.1 Introduction to the nanospanlastics
21.2 Composition and characteristics of nanospanlastics
21.3 Applications of nanospanlastic as a promising nanovesicle for drug delivery system
21.4 The therapeutic efficacy of nanospanlastics
21.5 Role of nanospanlastics for improving the bioavailability of natural plants
21.6 Role of nanospanlastics in drug repurposing treatment of animal diseases
21.7 Role of nanospanlastics for improving the topical delivery of inhibitor
21.8 Future of nanomedicine and drug delivery system
21.9 Conclusion
References
Further reading
Chapter 22. Stimuli-responsive nanovesicles for smart drug delivery
Abstract
22.1 Introduction
22.2 Challenges associated with conventional nanovesicles
22.3 Design considerations of various stimuli-responsive nanovesicles
22.4 Applications of stimuli-responsive nanovesicles
22.5 Conclusion
Conflict of interest
Acknowledgments
References
Chapter 23. Smart nanovesicles for drug delivery
Abstract
23.1 Introduction
23.2 Different types of nanovesicles
23.3 Synthetic nanovesicles
23.4 Methods of preparation of niosomes
23.5 Other types of nanovesicles
References
Chapter 24. Iontophoretic drug delivery systems
Abstract
24.1 Introduction
24.2 Historical background and development of iontophoresis
24.3 Iontophoresis drug delivery system components and mechanisms
24.4 Drug transport pathways
24.5 Factors affecting iontophoretic drug delivery
24.6 Pharmaceutical application of iontophoresis
24.7 Future formulation strategies using iontophoresis
24.8 Conclusion
References
Chapter 25. Ultrasound triggered nanovescicular drug delivery systems
Abstract
25.1 Introduction
25.2 Responsive drug delivery systems
25.3 Ultrasound triggered drug delivery carriers
25.4 Mechanism of drug delivery
25.5 Factors affecting drug delivery
25.6 Some recent studies
25.7 Underlying challenges and future prospects
25.8 Conclusions
References
Chapter 26. Nanovesicles for image-guided drug delivery
Abstract
26.1 Nanovesicles for photoacoustic image-guided drug delivery
26.2 Nanovesicles for ultrasound image-guided drug delivery
26.3 Nanovesicles for magnetic resonance image-guided drug delivery
26.4 Nanovesicles for positron emission tomography image-guided drug delivery
26.5 Nanovesicles for single-photon emission computed tomography image-guided drug delivery
26.6 Nanovesicles for multimodal image-guided drug delivery
References
Index

Amit Kumar Nayak

Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha ‘O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.

Affiliations and expertise

Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India

Md Saquib Hasnain

Prof. (Dr.) Md Saquib Hasnain has over 10 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 70 publications in various high impact peer-reviewed journals, more than 100 book chapters and 16 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record in Google Scholar (h-index: 32). He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.

Affiliations and expertise

Department of Pharmacy, Palamau Institute of Pharmacy, Daltonganj, Jharkhand, India

Tejraj M. Aminabhavi

Tejraj M. Aminabhavi is the Director of Research at the School of Advanced Sciences, KLE Technological University, Hubballi, India. He works in the area of membrane transport processes, molecular modeling of polymer surfaces, wastewater treatment technologies, drug delivery polymers and sustainable environmental engineering.

Affiliations and expertise

Director of Research, School of Advanced Sciences, KLE Technological University, Hubballi, Karnataka, India

Vladimir P. Torchilin

Dr Vladimir P. Torchilin is a University Distinguished Professor of Pharmaceutical Sciences and Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Mass. He graduated from the Moscow University with MS in Chemistry, and also obtained there his Ph.D. and D.Sc. in Polymer Chemistry, Chemical Kinetics and Catalysis, and Chemistry of Physiologically Active Compounds in 1971 and 1980, respectively. In 1991 Dr. Torchilin joined Massachusetts General Hospital and Harvard Medical School as the Head of Chemistry Program, Center for Imaging and Pharmaceutical Research, and Associate Professor of Radiology. Since 1998 Dr. Torchilin is with Northeastern University. He was there the Chair of the Department of Pharmaceutical Sciences in 1998-2008. His main interests include drug delivery and targeting, nanomedicine, multifunctional and stimuli-sensitive pharmaceutical nanocarriers, biomedical polymers, experimental cancer therapy, cancer immunology, novel imaging agents. He has published more than 500 original papers, more than 250 reviews and book chapters, wrote and edited 13 books, and hold more than 40 patents.

Affiliations and expertise

University Distinguished Professor of Pharmaceutical Sciences and Director, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USA