Systemic Lupus Erythematosus

1st Edition

A Companion to Rheumatology

Print ISBN: 9780323044349
eBook ISBN: 9780323070874
Imprint: Mosby
Published Date: 18th January 2007
Page Count: 608


This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find ‘one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment.

Key Features

  • Provides the very latest understanding of the pathogenesis of SLE.
  • Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease.
  • Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more.
  • Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage.
  • Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text.
  • Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon.
  • Discusses the latest treatment options on disease modifying or disease controlling agents.

Table of Contents

Epidemiology and Diagnosis

1. Epidemiology

2. Disease Activity Measures

3. Disease Outcome

4. Quality of Life and Economic Aspects


1. Overview of the Pathogenesis of SLE

2. Genetics

3. Hormones

4. Immunoregulation – T Cells, B cells, and cytokines.

5. Cell Surface Receptors ostimulation/BAFF/FcgR/TLRs)

6. Dendritic Cells

7. Apoptosis

8. Structure and Origin of Autoantibodies

9. Animal Models

10. Genetics of murine lupus

11. Infection and autoimmunity

Mechanisms of Tissue Damage

1. Complement

2. Immune complexes

3. Antibodies

a. ANA and standardization of antibody techniques

b. Anti-DNA

c. Anti-splicesomosal ab

d. Anti-Ro/La

e. Anti-Histone

f. APL

g. Anti-neuronal

4. PMNs

5. Mechanisms of renal damage

6. Mechanisms of vascular damage

7. Nitric Oxide

Clinical Aspects of the Disease

1. Constitutional Symptoms and Fatigue

2. Skin

3. Kidney

4. Heart

5. Lung

6. GI/liver/pancreas

7. Infections

8. Blood (anti-phospholipid syndrome)

9. Nervous System

10. Overlap Syndromes

11. Ophthalmic Manifestations

12. Pregnancy

13. Fertility

14. Neo-natal lupus

15. Hereditary and Malignant Lupus-like Diseases

Treatment of the Disease

1. Non-Steroidals – Anti-Malarials and Statins

2. Steroid Treatment

3. Cytotoxic Drug Treatment including M.M.F


5. New Treatments


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