Systemic Lupus Erythematosus

Systemic Lupus Erythematosus

Basic, Applied and Clinical Aspects

2nd Edition - April 7, 2020

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  • Editor: George Tsokos
  • Paperback ISBN: 9780128145517
  • eBook ISBN: 9780128145524

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This completely updated and expanded 2nd edition of Systemic Lupus Erythematosus, A Manual includes topics not covered previously with contributors who are at the forefront of each specific topic and with a global appeal. Each chapter is short and is presented critically with selected references, which should be valuable to a wider audience. This book combines basic with clinical science to help internists and specialists in the diagnosis and management of patients with SLE. It is a quick referral for people in the pharmaceutical industry in their efforts to bring much-needed drugs. It provides all the needed information to basic researchers old and new alike, who wish to enter the field of lupus and systemic autoimmunity in general.

Key Features

  • Focused state-of-the-art chapters prepared by top-notch experts in the field
  • Latest understanding of cellular, molecular, biochemical aspects of disease pathogenesis
  • Advanced aspects of genetic, microbiome, environmental, hormonal, and immunological contribution to the expression of the disease
  • Current understanding of clinical features of the disease
  • Recent efforts to develop new treatments


Researchers in basic, applied and clinical immunology

Table of Contents

  • Part I - Epidemiology and diagnosis
    1. History of systemic lupus erythematosus with an emphasis on certain recent major issues
    Shu Man Fu and Felicia Gaskin
    2. The patient
    Donald E. Thomas, Jr.
    3. A plea of a young patient to the lupus experts
    Brianna Fitzpatrick
    4. Epidemiology
    Manuel F. Ugarte-Gil, Guillermo J. Pons-Estel and Graciela S. Alarcón
    5. Measuring disease activity
    Joan T. Merrill
    6. Disease development and outcome
    Mary Mahieu, Dafna Gladman and Rosalind Ramsey-Goldman
    7. Socioeconomic aspects of SLE
    Titilola Falasinnu and Julia F. Simard
    8. Biomarkers in systemic lupus erythematosus
    Stacy P. Ardoin and Wael N. Jarjour

    Part II - Pathogenesis
    9. Overview of the pathogenesis of systemic lupus erythematosus
    Antonio La Cava
    10. System lupus erythematosus and the environment
    Soad Haj Yahia and Nancy Agmon-Levin
    11. Genes and genetics in human SLE
    Mara L. Lennard Richard and Betty P. Tsao
    12. Monogenic lupus
    Mindy S. Lo
    13. Hormones
    Takayuki Katsuyama and Vaishali R. Moulton
    14. Clinical aspects of the complement system in systemic lupus erythematosus
    John P. Atkinson, M. Kathryn Liszewski and C. Yung Yu
    15. T cells
    Florencia Rosetti and José C. Crispín
    16. B cells in SLE
    Andreia C. Lino and Thomas Dörner
    17. Neutrophils in systemic lupus erythematosus
    Amr H. Sawalha
    18. The role of dendritic cells in systemic lupus erythematosus
    Manon Charrier, Christophe Richez, Estibaliz Lazaro, Vanja Sisirak and Patrick Blanco
    19. Cytokines
    Takayuki Katsuyama and Vaishali R. Moulton
    20. RNA/DNA sensing in SLE—Toll-like receptors and beyond
    Caroline A. Jefferies and Amir Sharabi
    21. The role of interferons in systemic lupus erythematosus
    Ruth Fernandez-Ruiz and Timothy Niewold
    22. Fcγ receptors in autoimmunity and endorgan damage
    T. Ernandez, K. Okubo, G. Saggu and T.N. Mayadas
    23. Apoptosis, autophagy, and necrosis
    Roberto Caricchio
    24. Infections in early systemic lupus erythematosus pathogenesis
    Rebecka Bourn, Samantha Slight-Webb and Judith A. James
    25. Microbiota influences on systemic lupus erythematosus and Sjögren’s syndrome
    Teri M. Greiling, Silvio Manfredo Vieira and Martin A. Kriegel
    26. Origin of autoantibodies
    Westley H. Reeves, Shuhong Han and Haoyang Zhuang
    27. Anti-DNA antibodies
    Susan Malkiel, Yemil Atisha-Fregoso and Betty Diamond
    28. Antihistone and antispliceosome antibodies
    Minoru Satoh, Marvin J. Fritzler and Edward K.L. Chan
    29. Immune complexes in systemic lupus erythematosus
    Keiju Hiromura and Masaomi Nangaku
    30. MicroRNA in systemic lupus erythematosus
    Bo Qu, Xiaoyue Jiang and Nan Shen
    31. Metabolic control of lupus pathogenesis: central role for activation of the mechanistic target of rapamycin
    Andras Perl
    32. Epigenetics
    Christian M. Hedrich
    33. What do mouse models teach us about human SLE?
    Ziaur S.M. Raman and Chandra Mohan
    34. Genes and genetics of murine systemic lupus erythematosus
    Dwight H. Kono and Argyrios N. Theofilopoulos

    Part III - Mechanisms of tissue damage
    35. Mechanisms of renal damage in systemic lupus erythematosus
    Shu Man Fu, Sun-Sang J. Sung, Hongyang Wang, Zhenhuan Zhao and Felicia Gaskin
    36. Mechanisms of vascular damage in systemic lupus erythematosus
    Sarfaraz A. Hasni and Mariana J. Kaplan
    37. The mechanism of skin damage
    Xin Huang, Haijing Wu, Christopher Chang and Qianjin Lu
    38. Pathogenesis of tissue injury in the brain in patients with systemic lupus erythematosus
    David Hunt

    Part IV - Clinical aspects of the disease
    39. Constitutional symptoms and fatigue in systemic lupus erythematosus
    Syahrul Sazliyana Shaharir and Caroline Gordon
    40. The musculoskeletal system in SLE
    Maria-Louise Barilla-LaBarca, Diane Horowitz, Galina Marder and Richard Furie
    41. Cutaneous lupus erythematosus
    Annegret Kuhn, Aysche Landmann and Gisela Bonsmann
    42. The clinical evaluation of kidney disease in systemic lupus erythematosus
    Brad H. Rovin, Isabelle Ayoub and Swati Arora
    43. The pathology of lupus nephritis
    Isaac Ely Stillman
    44. Cardiovascular disease in systemic lupus erythematosus: an update
    Stephanie Saeli, Tanmayee Bichile, Payal Thakkar and Susan Manzi
    45. The lung in systemic lupus erythematosus
    Lindsy Forbess, Daniel J. Wallace and Caroline Jefferies
    46. Gastrointestinal, hepatic, and pancreatic disorders in systemic lupus erythematosus
    Chi Chiu Mok
    47. Systemic lupus erythematosus and infections
    Amy Devlin and Robert H. Shmerling
    48. Malignancies in systemic lupus erythematosus
    Alexandra Ladouceur, Hiromi Tissera, Ann E. Clarke, Rosalind Ramsey-Goldman, Caroline Gordon, James E. Hansen and Sasha Bernatsky
    49. The nervous system in systemic lupus erythematosus
    David Hunt
    50. Overlap syndromes
    Eric L. Greidinger
    51. Systemic lupus erythematosus and the eye
    Erika M. Damato, Philip I. Murray and Alastair K.O. Denniston
    52. Fertility and pregnancy in systemic lupus erythematosus
    Bonnie L. Bermas and Lisa R. Sammaritano
    53. Neonatal lupus
    Clinical spectrum, biomarkers, pathogenesis, and approach to treatment
    Jill P. Buyon, Amit Saxena, Peter M. Izmirly, Bettina Cuneo and Benjamin Wainwright
    54. Incomplete lupus syndromes
    Nancy J. Olsen
    55. Lupus in children
    Mindy S. Lo
    56. Drug-induced lupus
    Robert L. Rubin
    57. Vasculitis in lupus
    Anisur Rahman

    Part V - Antiphospholipid Syndrome
    58. Pathogenesis of antiphospholipid syndrome
    Olga Amengual and Tatsuya Atsumi
    59. Antibodies and diagnostic tests in antiphosholipid syndrome
    Cecilia Beatrice Chighizola, Maria Orietta Borghi and Pier Luigi Meroni
    60. Clinical manifestations
    Miyuki Bohgaki and Takao Koike
    61. Nonsteroidal antiinflammatory drugs in systemic lupus erythematosus
    Robert G. Lahita and Trina Pal
    62. Value of antimalarial drugs in the treatment of lupus
    Fadi Hassan, Mohammad E. Naffaa and Ziv Paz
    63. Systemic glucocorticoids
    Zahi Touma and Murray B. Urowitz
    64. Cytotoxic drug treatment
    Eleni A. Frangou, George Bertsias and Dimitrios T. Boumpas
    65. Treatment of antiphospholipid syndrome
    Savino Sciascia and Munther Khamashta
    66. New treatments of systemic lupus erythematosus
    Vasileios C Kyttaris
    67. Repositioning drugs for systemic lupus erythematosus
    Kathryn M. Kingsmore, Peter E. Lipsky and Amrie C. Grammer

Product details

  • No. of pages: 694
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: April 7, 2020
  • Imprint: Academic Press
  • Paperback ISBN: 9780128145517
  • eBook ISBN: 9780128145524

About the Editor

George Tsokos

George Tsokos
After receiving an MD from University of Athens, he came to the Arthritis Branch in 1979 where he trained in immunology and rheumatology. Between 1987 and 2007 he was a member of the Uniformed Services/Walter Reed community where served in various positions including Vice Chair for Research in the Department of Medicine and Chief of the Department of Cell Injury. In 2007 he joined the Beth Israel Medical Center as Chief of Rheumatology and Harvard Medical School as Professor of Medicine. He has served various leadership positions including President of the Clinical Immunology Society. He has served as chair of the Hypersensitivity, Autoimmunity, and Immune Mediated Diseases Study Section of the National Institutes of Health, Editor-in-Chief of Clinical Immunology, the official journal of FOCIS, and editor of Autoimmunity and Discovery Medicine, PLoS One and other journals. He has been elected to the Association of American Physicians, Fellow of the American Association for the Advancement of Sciences and Master of the American College of Physicians (MACP). He is the 2012 Lee C. Howley Jr. Arthritis Research Prize from the Arthritis Foundation and a MERIT award holder from NIH. Dr. Tsokos’ research focuses on the cellular and molecular pathogenesis of systemic lupus erythematosus (SLE). His laboratory has opened and led the field of molecular abnormalities on immune cells in patients with SLE. He directs a T32-sponsored fellowship on systemic autoimmunity and a Clinical Rheumatology Fellowship. Dr. Tsokos has trained over 110 colleagues many of whom hold senior leadership positions and run independent laboratories. His research is funded through NIH and DoD grants.

Affiliations and Expertise

Professor of Medicine, Harvard Medical School, and Chief, Rheumatology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA

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