Systemic Lupus Erythematosus - 4th Edition - ISBN: 9780124339019, 9780080474540

Systemic Lupus Erythematosus

4th Edition

Editors: Robert Lahita
eBook ISBN: 9780080474540
Hardcover ISBN: 9780124339019
Imprint: Academic Press
Published Date: 12th May 2004
Page Count: 1343
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Systemic Lupus Erythematosus, Fourth Edition, provides an understanding of the basic mechanisms as well as the diagnostic and therapeutic aspects of lupus. This book is attractive to both the investigative community and clinicians. As lupus has become a paradigm for the study of autoimmune disease, immunologists investigating autoimmunity are becoming more interested in lupus. Basic immunology of phospholipid antibodies, clotting abnormailities, issues concerning pathogenetic fit with SLE, and newest methods of therapy of APLS are given in this newest edition of a classic reference.

Key Features

  • Comprehensive current coverage of basic models of etiology and pathogenesis
  • Complete catalog of autoantibodies produced
  • Includes an outstanding review of imaging techniques for the diagnosis of lupus and its complications for each organ system
  • Includes CD-ROM of images excellent for teaching purposes and downloading into presentations


Immunologists, basic and clinical researchers, rheumatologists, dermatologists, clinical researchers studying women and health, hospital and medical school libraries.

Table of Contents

Introduction to 4th Edition
Autoimmunity and Autoimmune Diseases like Systemic Lupus Erythematosus
Overview of Cellular Immune Function in Systemic Lupus Erythematosus
Etiopathogenesis of Systemic Lupus Erythematosus: The Itineraries of Three Troikas
MHC Class II and Non-MHC Genes in the Pathogenesis of Systemic Lupus Erythematosus
Genetic Susceptibility and Class III Complement Genes
Complement Deficiency and Systemic Lupus Erythematosus
Gender and Age in Systemic Lupus Erythematosus
Animal Models
Genes and Genetics of Murine Systemic Lupus Erythematosus
Systemic Lupus Erythematosus in Domestic Animals

Autoantibodies and Antigens
Anti-DNA Antibodies : Structure, Assembly and Diversity
Antibodies to Cytoplasmic Antigens
Antihistone Antibodies
Antibodies to Non-Histone Agents in Systemic Lupus Erythematosus
Immune Complexes
Origins of Antinuclear Antibodies

Clinical Approach to Diagnosis
The Clinical Presentation of Systemic Lupus Erythematosus
Neonatal Systemic Lupus Erythematosus Syndromes
Systemic Lupus Erythematosus in Childhood
Imaging of Systemic Lupus Erythematosus: State of the Art
Monitoring Patients and Systemic Lupus Erythematosus
Laboratory Evaluation of Patients with Systemic Lupus Erythematosus
Systemic Lupus Erythematosus Pregnancy
Epidemiology of Systemic Lupus Erythematosus
Overlap Syndromes: Mixed Connective Tissue Disease and Sjögren's Syndrome
Systemic Lupus Erythematosus and Fibromyalgia

Organs Affected by Systemic Lupus Erythematosus
Nervous system:
Central Nervous System Systemic Lupus Erythematosus
Psychiatric Aspects of Systemic Lupus Erythematosus
Cognitive Dysfunction in Systemic Lupus Erythematosus
Systemic Lupus Erythematosus and the Skin
Systemic Lupus Erythematosus and the Kidney
Cardiovascular Systemic Lupus Erythematosus
Systemic Lupus Erythematosus and the Cardiovascular System: Vasculitis
Systemic Lupus Erythematosus and the Lung
Nonhepatic Gastrointestinal Manifestations of Systemic Lupus Erythematosus
Hepatic Disease and Systemic Lupus Erythematosus: Coincidence or Converence
The Cellular Hematology of Systemic Lupus Erythematosus
Articular Manifestations of Systemic Lupus Erythematosus
Osteoporosis and Metabolic Bone Disease in Systemic Lupus Erythematosus

Specific Syndromes
Phospholipid Syndrome:
Immunology of Antiphospholipid Antibodies and Co-factors
The Clinical Aspects of the Antiphospholipid Syndrome
The Catastrophic Phospholipid Syndrome
Hematology: Coagulation Problems
The Antiphospholipid Syndrome: Pathogenesis and Implications for Systemic Lupus Erythematosus
Drug Induced Systemic Lupus Erythematosus:
Pathophysiology of Drug-Induced Systemic Lupus Erythematosus
Drug and Environmental Systemic Lupus Erythematosus: Clinical Manifestations and Differences
Therapy of Systemic Lupus Erythematosus
Corticosteroid Use in Systemic Lupus Erythematosus
Antimalarials and Immunosuppresive Therapies
Unproven and Experimental Therapies


No. of pages:
© Academic Press 2004
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Robert Lahita

Affiliations and Expertise

ROBERT G. LAHITA MD, PhD Professor of Medicine, Adjunct Professor of Biochemistry and Molecular Biology UMDNJ, New Jersey Medical School Vice President and Chairman of Medicine Newark Beth Israel Medical Center Newark, NJ, USA


From Previous Edition: "This book successfully links basic science with clinical medicine, providing a framework within which to understand this complex disease. As Lahita states in the introduction, 'The history of discovery is now in the log phase of growth.' The third edition of Systemic Lupus Erythematosus conveys the excitement and the breadth of this dynamic field. This volume will be an excellent resource for basic and clinical scientists, as well as for the students of imunology and rheumatology. The chapters are well-referenced and can be read independently- as befits a reference book." -Jane E. Salmon, Weill Medical College, Cornell University, New York, USA (March 2000)