Systemic Lupus Erythematosus

5th Edition

Editors: Robert Lahita
Hardcover ISBN: 9780123749949
eBook ISBN: 9780080961712
Imprint: Academic Press
Published Date: 29th October 2010
Page Count: 1154
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Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission.

Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.

To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients.

A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

Key Features

  • Highly illustrated and in full color throughout
  • Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment
  • Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice


Primary audience is basic scientists and clinicians who are interested in SLE including rheumatologists, dermatologists, nephrologists, immunologists and allergists.

Secondary audience is residents and fellows in training, primary internists with an interest in the disease and medical libraries.

Table of Contents

Section I: Basis of Disease Pathogenesis

A. Genetics

1 Major histocompatibility complex class II

Michelle M.A. Fernando and Timothy J. Vyse

2 Genetic susceptibility and class III complement genes

John P. Atkinson, Peter M. Schneider and C. Yung Yu

3 Constitutive genes and lupus

Betty P. Tsao and Yun Deng

4 Genetics of lupus in mice

Dwight H. Kono and Argyrios N. Theofilopoulos

B. Cellular Pathogenesis

5 Tolerance and autoimmunity

Shiv Pillai and Kendra N. Taylor

6 Dendritic cells in SLE

Gerlinde Obermoser, Karolina Palucka, Hideki Ueno, Jacques Banchereau, and Virginia Pascual

7 T cells and systemic lupus erthematosus

Jose C. Crispin and George C. Tsokos

8 B-lymphocyte biology in SLE

Mark J. Mamula

9 Polymorhonuclear and endothelial cells

Robert Clancy

10 Mechanisms and consequences of mitochondrial dysfunction and oxidative stress in T cells of patients with SLE

Andras Perl

11 Cell cycle regulation and systemic lupus erythematosus

Dimitrios Balomenos

12 The role of reactive nitrogen and oxygen intermediates in systemic lupus erythematosus

Ahmad K. Mashmoushi, Gary S. Gilkeson and Jim C. Oates

C. Humoral Pathogenesis

13 Origins of antinuclear antibodies

Westley H. Reeves, Yuan Xu, Haoyang Zhuang, Yi Li and Lijun Yang

14 Anti-DNA antibodies: Structure, regulation and pathogenicity

Cynthia Aranow, Dun Zhou and Betty Diamond

15 Extractable nuclear antigens and SLE: specificity and role in disease pathogenesis

Mary Keogan, Grainne Kearns and Caroline A. Jefferies

16 Antihistone and antispliceosomal antibodies

Minoru Satoh, Marvin J. Fritzler, and Edward K.L. Chan

17 Toll-like receptors in SLE

Terry K. Means

18 Interferon-alpha in systemic lupus erythematosus

Mary K. Crow



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© Academic Press 2011
Academic Press
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About the Editor

Robert Lahita

Affiliations and Expertise

ROBERT G. LAHITA MD, PhD Professor of Medicine, Adjunct Professor of Biochemistry and Molecular Biology UMDNJ, New Jersey Medical School Vice President and Chairman of Medicine Newark Beth Israel Medical Center Newark, NJ, USA


"The first edition was published in 1987, and revisions every five or six years have kept this reference up to date. An earlier edition was cited in Brandon-Hill, but, surprisingly, this work is absent from the Medical Library Association's Master Guide.... Like its predecessors, this reference aims for comprehensiveness, and this fifth edition incorporates an abundance of new terms and concepts, key opinions from researchers and clinicians, and, for the first time, ‘...ways to approach, examine and quantify clinical facts from lupus patients.’ Chapters are organized in sections on the basis of disease pathogenesis (e.g. genetics, cellular pathogenesis, humoral pathogenesis, environmental aspects, mechanisms of tissue injury); clinical aspects; anti-phospholipid syndrome; and treatment. Editor Robert G. Lahita (New Jersey Medical School, and Newark Beth Israel Medical Center) is joined for this edition by three associate editors: George Tsokos (Beth Israel Deaconess Medical Center); Jill P. Buyon (NYU Medical Center); and Takao Koike (Hokkaido U. School of Medicine, Japan)."--SciTech Book News