Synthetic Peptides

Synthetic Peptides

Volume 3

First published on January 28, 1975

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  • Author: George R. Pettit
  • eBook ISBN: 9781483262826

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Synthetic Peptides discusses racemization, protecting group techniques, peptide bond-forming methodology, amino acids, and dipeptide syntheses. The book explains solid phase synthesis methods, cyclopeptides, nucleopeptides, chromopeptides of the actinomycin D type, and cites examples of syntheses of peptides of different sizes. The text describes tripeptides, tetrapeptides, pentapeptides, hexapeptides, and also undecapeptides to nonadecapeptides. Riniker and colleagues explain the revised structures (for the human and porcine hormone, Asn for Asp at position 25 and Glu for Gin at position 30) for the 39-unit adrenocorticotropic hormone. A synthesis of the 32-unit human calcitonin M is associated with the fragment condensation approach to complex peptides. The book also reviews cyclodepsipeptide valinomycin based on the possible transport of a potassium ion through biological membranes by this substance and the synthesis of a D-Pro analog. The text describes the cyclic decapeptide antibiotic gramicidin S, belonging to a family of similar substances isolated from Bacillus brevi, that can treat certain eye-threatening infections. The book can prove beneficial for biochemists, micro-biologists, cellular investigators, and researchers involved in physiology, oncology or therapeutics.

Table of Contents

  • Preface

    Introduction and Glossary

    Chapter 1 Racemization

    Chapter 2 Amino Acids and Derivatives

    Chapter 3 Dipeptides

    Chapter 4 Tripeptides

    Chapter 5 Tetrapeptides

    Chapter 6 Pentapeptides

    Chapter 7 Hexapeptides

    Chapter 8 Heptapeptides

    Chapter 9 Octapeptides

    Chapter 10 Nonapeptides

    Chapter 11 Decapeptides

    Chapter 12 Undecapeptides to Nonadecapeptides

    Chapter 13 Peptides of 20 to 188 Units

    Chapter 14 Solid Phase Synthesis

    Chapter 15 Polypeptides

    Chapter 16 Cyclopeptides

    Chapter 17 Depsipeptides and Cyclodepsipeptides

    Chapter 18 Steroidal Peptides

    Chapter 19 Chromopeptides

    Chapter 20 Nucleopeptides



Product details

  • No. of pages: 446
  • Language: English
  • Copyright: © Academic Press 1975
  • Published: January 28, 1975
  • Imprint: Academic Press
  • eBook ISBN: 9781483262826

About the Author

George R. Pettit

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