- Print ISBN 9780123944306
- Electronic ISBN 9780123978202
Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems.
Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems.
Geneticists, molecular biologists, physicists, chemists, and bioengineers
Synthetic Biology: What is in a Name?
Synthetic Biology: What’s New?
Synthetic Biology: What’s Next?
Section I: Synthesis and Engineering Tools in Synthetic Biology
Chapter 1. New Tools for Cost-Effective DNA Synthesis
Applications of DNA Synthesis
Chapter 2. Protein Engineering as an Enabling Tool for Synthetic Biology
Protein Engineering Methods
Applications of Protein Engineering in Synthetic Biology
Chapter 3. Pathway Engineering as an Enabling Synthetic Biology Tool
Design and Construction of Pathways
Applications of Pathway Engineering Tools
Conclusions and Future Prospects
Chapter 4. From Biological Parts to Circuit Design
Section II: Computational and Theoretical Tools in Synthetic Biology
Chapter 5. Theoretical Considerations for Reprogramming Multicellular Systems
Conceptual Framework: Gene Regulatory Networks, Network States, and Cell Types
The Quasi-Potential Landscape
How to Obtain a Trajectory on the Quasi-Potential Landscape for Transition Between Two Attractors
Example: State Transition in Blood Cell and Pancreas Cell Differentiation and Reprogramming
Conclusion and Outlook
Chapter 6. Computational Protein Design for Synthetic Biology
Computational Design of Protein–protein I
"Synthetic Biology: Tools and Applications. Edited by Huimin Zhao. Academic Press. Amsterdam (The Netherlands) and Boston (Massachusetts): Elsevier. $149.95. xviii 333 p.; ill.; index. ISBN: 978-0-12-394430-6. 2013." - The Quarterly Review of Biology,September 2014
"Chemical, biological, and biochemical engineers describe tools and methodologies developed for engineering biological systems at a wide range of levels, including molecular, pathway, network, whole cell, and multi-cell. They also explore practical applications of synthetic biology, a branch of genetic engineering that incorporates systems biology."--Reference and Research Book News, August 2013