Synthetic Analgesics - 1st Edition - ISBN: 9780080093109, 9781483152172

Synthetic Analgesics

1st Edition

Diphenylpropylamines

Authors: Paul A. J. Janssen
Editors: D. H. R. Barton W. Doering
eBook ISBN: 9781483152172
Imprint: Pergamon
Published Date: 1st January 1960
Page Count: 192
Sales tax will be calculated at check-out Price includes VAT/GST
31.95
22.36
22.36
22.36
25.56
22.36
22.36
25.56
19.99
13.99
13.99
13.99
15.99
13.99
13.99
15.99
24.95
17.46
17.46
17.46
19.96
17.46
17.46
19.96
Unavailable
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Description

Synthetic Analgesics, Part I: Diphenylpropylamines deals with the methods of synthesis, the physical and chemical properties, and the ""analgesic"" activity of diphenylpropylamines. Topics covered include the ""analgesic"" activity of methadone, morphine, pethidine, and codeine in animals; diamines and derivatives; R875 and related basic tertiary amides; esters derived from amino acids and secondary and tertiary alcohols; and ketimines, acyl ketimines, and ketones. This book is comprised of 21 chapters and begins with a brief background on the first chemical and pharmacological experiments on diphenylpropylamines, followed by a discussion on ""analgesic"" activity in humans and animals. The ""analgesic"" activity of methadone, morphine, pethidine, and codeine in animals is considered. The following chapters explore a variety of compounds such as 3:3-diphenylpropylamines, tertiary alcohols, secondary alcohols, primary alcohols, nitriles, diamines and derivatives, primary and secondary amides, acids and acid chlorides, and aldehydes. Sulfones, dissociation constants, and configurational studies are also described. This monograph will be a useful resource for researchers and practitioners in the fields of organic chemistry, analytical chemistry, and pharmacology.

Table of Contents

Preface

Introduction

Chapter I: "Analgesic" Activity in Man and in Animals

Publisher Summary

Chapter II: The "Analgesic"Activity of Methadone, Morphine, Pethidine and Codeine in Animals

Publisher Summary

Chapter III: 3:3-Diphenylpropylamines (I : R = H)

Publisher Summary

Chapter IV: Tertiary Alcohols (I : R = OH)

Publisher Summary

(a) Methods 1 and 2: Grignard reactions

(b) Method 3

(c) Method 4

(d) Methods 5 and 6

(e) Methods 7 and 8 (unpublished results)

Chapter V: Secondary Alcohols (I : R = CHOH alk)

Publisher Summary

Chapter VI: Primary Alcohols [I : R = (CH2)n – OH; n = 1, 2, 3]

Publisher Summary

Chapter VII: Nitriles (I : R = CN)

Publisher Summary

Chapter VIII: Diamines and Derivatives (I : R Contains Amino Group or Derivative)

Publisher Summary

Chapter IX: Primary Amides (I : R = CONH2)

Publisher Summary

Chapter X: Acids and Acid Chlorides (I : R = COOH or COCl)

Publisher Summary

Chapter XI: Secondary Amides (I : R = CONHR′)

Publisher Summary

Chapter XII: R 875 and Related Basic Tertiary Amides (I : R = CONR′R″)

Publisher Summary

Chapter XIII: Esters derived from Amino Acids of Type I (R = COOR′)

Publisher Summary

Chapter XIV: Esters derived from Tertiary Alcohols (I : R = OCOR′)

Publisher Summary

Chapter XV: Esters derived from Secondary Alcohols (I : R = CHOCOR″.R′)

Publisher Summary

Chapter XVI: Ketimines, Acyl Ketimines and Ketones (I : R = CNHR′, CNCOR″R′, COR′)

Publisher Summary

Chapter XVII: Aldehydes (I : R = COH)

Publisher Summary

Chapter XVIII: Sulphones (I : R = SO2R′)

Publisher Summary

Chapter XIX: Other Compounds of Structure (I)

Publisher Summary

Chapter XX: Dissociation Constants

Publisher Summary

Chapter XXI: Configurational Studies

Publisher Summary

REFERENCES

Details

No. of pages:
192
Language:
English
Copyright:
© Pergamon 1960
Published:
Imprint:
Pergamon
eBook ISBN:
9781483152172

About the Author

Paul A. J. Janssen

About the Editor

D. H. R. Barton

W. Doering

Ratings and Reviews