Synthetic Analgesics - 1st Edition - ISBN: 9780080093109, 9781483152172

Synthetic Analgesics

1st Edition

Diphenylpropylamines

Authors: Paul A. J. Janssen
Editors: D. H. R. Barton W. Doering
eBook ISBN: 9781483152172
Imprint: Pergamon
Published Date: 1st January 1960
Page Count: 192
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Description

Synthetic Analgesics, Part I: Diphenylpropylamines deals with the methods of synthesis, the physical and chemical properties, and the ""analgesic"" activity of diphenylpropylamines. Topics covered include the ""analgesic"" activity of methadone, morphine, pethidine, and codeine in animals; diamines and derivatives; R875 and related basic tertiary amides; esters derived from amino acids and secondary and tertiary alcohols; and ketimines, acyl ketimines, and ketones. This book is comprised of 21 chapters and begins with a brief background on the first chemical and pharmacological experiments on diphenylpropylamines, followed by a discussion on ""analgesic"" activity in humans and animals. The ""analgesic"" activity of methadone, morphine, pethidine, and codeine in animals is considered. The following chapters explore a variety of compounds such as 3:3-diphenylpropylamines, tertiary alcohols, secondary alcohols, primary alcohols, nitriles, diamines and derivatives, primary and secondary amides, acids and acid chlorides, and aldehydes. Sulfones, dissociation constants, and configurational studies are also described. This monograph will be a useful resource for researchers and practitioners in the fields of organic chemistry, analytical chemistry, and pharmacology.

Table of Contents

Preface

Introduction

Chapter I: "Analgesic" Activity in Man and in Animals

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Chapter II: The "Analgesic"Activity of Methadone, Morphine, Pethidine and Codeine in Animals

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Chapter III: 3:3-Diphenylpropylamines (I : R = H)

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Chapter IV: Tertiary Alcohols (I : R = OH)

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(a) Methods 1 and 2: Grignard reactions

(b) Method 3

(c) Method 4

(d) Methods 5 and 6

(e) Methods 7 and 8 (unpublished results)

Chapter V: Secondary Alcohols (I : R = CHOH alk)

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Chapter VI: Primary Alcohols [I : R = (CH2)n – OH; n = 1, 2, 3]

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Chapter VII: Nitriles (I : R = CN)

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Chapter VIII: Diamines and Derivatives (I : R Contains Amino Group or Derivative)

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Chapter IX: Primary Amides (I : R = CONH2)

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Chapter X: Acids and Acid Chlorides (I : R = COOH or COCl)

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Chapter XI: Secondary Amides (I : R = CONHR′)

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Chapter XII: R 875 and Related Basic Tertiary Amides (I : R = CONR′R″)

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Chapter XIII: Esters derived from Amino Acids of Type I (R = COOR′)

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Chapter XIV: Esters derived from Tertiary Alcohols (I : R = OCOR′)

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Chapter XV: Esters derived from Secondary Alcohols (I : R = CHOCOR″.R′)

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Chapter XVI: Ketimines, Acyl Ketimines and Ketones (I : R = CNHR′, CNCOR″R′, COR′)

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Chapter XVII: Aldehydes (I : R = COH)

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Chapter XVIII: Sulphones (I : R = SO2R′)

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Chapter XIX: Other Compounds of Structure (I)

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Chapter XX: Dissociation Constants

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Chapter XXI: Configurational Studies

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REFERENCES

Details

No. of pages:
192
Language:
English
Copyright:
© Pergamon 1960
Published:
Imprint:
Pergamon
eBook ISBN:
9781483152172

About the Author

Paul A. J. Janssen

About the Editor

D. H. R. Barton

W. Doering