Synthesis of Azetidines from Imines by Cycloaddition Reactions

Synthesis of Azetidines from Imines by Cycloaddition Reactions

1st Edition - January 1, 2023

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  • Author: Navjeet Kaur
  • Paperback ISBN: 9780443192043

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Description

Imines to azetidines by cycloaddition presents detailed information about the synthesis of azetidines from imines by cycloaddition reactions. The synthesis of azetidines is a constant challenge for medicinal chemists, and this book that comprehensively describes azetidine ring synthesis. The readers are able to quickly assess the possible synthetic approaches, and evaluate whether preparation of a four-membered nitrogen containing ring is reasonable. The formation of heterocycles has always attracted attention over the years due to their important medicinal properties. This book presents several methodologies for the synthesis of azetidines from imines by cycloaddition reactions and the readers will defiantly gain knowledge about the topic. The azetidines, known as important contribution of science to humanity are important organic compounds and occupy a basic position in pharmaceutical chemistry for over hundred years now because of their biological activities. They are the fundamental skeleton of several antibiotics, probiotics, and alkaloids.

Key Features

  • Highlights cycloaddition reactions of imines
  • Covers synthesis of azetidines

Readership

Students and Researchers in Chemistry, Synthetic Chemists, Organic Chemists

Table of Contents

  • Chapter-1: Synthesis of azetidines from imines
    1.1 Introduction
    1.2 Synthesis of azetidines from imines
    1.3 Synthesis of azetidines from imines and carbon monoxide
    1.4 Synthesis of azetidines from haloimine compounds
    References

    Chapter-2: Synthesis of azetidines by cycloaddition of imines to alkenes
    2.1 Introduction
    2.2 Synthesis of azetidines by cycloaddition of imines to alkenes
    2.3 Synthesis of azetidines by LDA-assisted cycloaddition of imines to alkenes
    2.4 Synthesis of azetidines by lithium-assisted cycloaddition of imines to alkenes
    References

    Chapter-3: Synthesis of azetidines by metal-catalyzed cycloaddition of imines to alkenes
    3.1 Introduction
    3.2 Synthesis of azetidines by metal vinylidene-catalyzed cycloaddition of imines to alkenes
    3.3 Synthesis of azetidines by metal-catalyzed cycloaddition of imines to alkenes
    3.4 Synthesis of azetidines by titanium-catalyzed cycloaddition of imines to alkenes
    References

    Chapter-4: Synthesis of azetidines by cycloaddition of imines to ketenes-I
    4.1 Introduction
    4.2 Synthesis of azetidines by cycloaddition of imines to ketenes
    References

    Chapter-5: Synthesis of azetidines by cycloaddition of imines to ketenes-II
    5.1 Introduction
    5.2 Synthesis of azetidines by ferrocene-assisted cycloaddition of imines to ketenes
    5.3 Synthesis of azetidines by N-heterocyclic carbene-assisted cycloaddition of imines to ketenes
    5.4 Synthesis of azetidines by metal-assisted cycloaddition of imines to ketenes
    5.5 Synthesis of azetidines by polymer-supported reagent-assisted cycloaddition of imines to ketenes
    5.6 Synthesis of azetidines by triethylamine-assisted cycloaddition of imines to ketenes
    References

    Chapter-6: Synthesis of azetidines by cycloaddition of imines to carbonyl compounds
    6.1 Introduction
    6.2 Synthesis of azetidines by intramolecular cycloaddition of imine to carbonyl moiety using NaHMDS
    6.3 Synthesis of azetidines by cycloaddition of imines to carbonyl compounds using zinc reagents
    6.4 Miscellaneous synthesis of azetidines by cycloaddition of imines to carbonyl compounds
    References

    Chapter-7: Synthesis of azetidines by cycloaddition of imines to acetyl chloride moiety
    7.1 Introduction
    7.2 Synthesis of azetidines by cycloaddition of imines to acetyl chloride moieties
    7.3 Synthesis of azetidines by cycloaddition of imines to acetoxyacetyl chlorides
    7.4 Synthesis of azetidines by cycloaddition of imines to methoxyacetyl chlorides
    7.5 Synthesis of azetidines by cycloaddition of imines to oxazolidinylacetyl chlorides
    7.6 Synthesis of azetidines by cycloaddition of imines to proline acid chlorides
    References

    Chapter-8: Synthesis of azetidines by cycloaddition of imines to aromatic acetyl chloride moiety
    8.1 Introduction
    8.2 Synthesis of azetidines by cycloaddition of imines to benzyloxyacetyl chlorides
    8.3 Synthesis of azetidines by cycloaddition of imines to phenoxyacetyl chlorides
    8.4 Synthesis of azetidines by cycloaddition of imines to phenylacetyl chlorides
    References

    Chapter-9: Synthesis of azetidines by cycloaddition of imines to chloroacetyl chloride-I
    9.1 Introduction
    9.2 Synthesis of azetidines by cycloaddition of imines to chloroacetyl chloride
    9.3 Synthesis of azetidines by cycloaddition of imines to chloroacetyl chloride using triethylamine and dioxane
    References

    Chapter-10: Synthesis of azetidines by cycloaddition of imines to chloroacetyl chloride-II
    10.1 Introduction
    10.2 Synthesis of azetidines by cycloaddition of imines to chloroacetyl chloride using triethylamine
    References

Product details

  • Language: English
  • Copyright: © Elsevier 2023
  • Published: January 1, 2023
  • Imprint: Elsevier
  • Paperback ISBN: 9780443192043

About the Author

Navjeet Kaur

Dr. Navjeet Kaur received her BSc from Panjab University Chandigarh (Panjab, India) in 2008. In 2010, she completed her MSc in Chemistry from Banasthali Vidyapith. She was awarded with PhD in 2014 by the same university.  With 11 years of teaching experience, she has published over 160 scientific research papers, review articles, book chapters, and monographs in the field of organic synthesis in national and international reputed journals. She has published five authored books: with Elsevier. She secured her place amongst top 2% scientists of the world in 2017 (single year ranking), 2018 (full career wise ranking), 2019 [full career wise ranking with 424 world rank (04 in India) and single year ranking with 03 world rank (01 in India)] and 2020 (full career wise ranking with 372 world rank and single year ranking with 126 world rank). In 2021, Dr. Kaur was chosen as a candidate for membership by Royal Society of Research, London, England, UK with full waiver of application fees. She is serving as an Editor-in-Chief for “Advanced Chemicobiology Research” journal.

Affiliations and Expertise

Department of Chemistry, Banasthali Vidyapith University, India

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