With the recent changes in the health care industry, surgeons face increasing pressure to devote their time to their clinical activities, thus limiting their research efforts. It is essential that young and creative individuals are encouraged to perform research and are given incentives to participate in research under the mentorship of more experienced research investigators. Surgical Research is the first book to include all the information necessary for the surgical scientist to perform a research experiment. The editors have assembled outstanding, expert investigators in multiple surgical fields and asked them to describe how they achieve their research accomplishments. In Surgical Research, these experts in the field have outlined everything involved in preparing and conducting a research project. Some of the topics covered in the book include how to state a research question, how to review the available information, how to write research protocol, how to obtain grant money for the experiment, how to analyze the data, and how to present the findings. Also discussed are the ethics of animal and human experimentation along with the history and philosophy of surgical research. To continue to advance technologies and surgical methods, research must continually be performed. Potentially great discoveries are being missed because would-be researchers do not know where to start or how to conduct research, and therefore do not even try. This book provides prospective researchers with all the basic steps needed to perform a research experiment in the surgical field. No student, resident, or fellow should start a research project without this book and no senior surgical scientist should be without it occupying a prominent position in the library.

Key Features

Key Features * The first complete compendium detailing the process and procedures to perform surgical research * Provides details on and compares various methodologies * A "must have" resource for the surgical resident, fellow, or scientist * Includes a listing of resources and web sites to help the researcher even further


Academic and practicing surgeons, residents, and fellows.

Table of Contents

Contributors. Foreword. Preface. Getting Started. Assessing Available Information. Organizing and Preliminary Planning for Surgical Research Writing a Protocol: Animals, Humans, and Use of Biologic, Chemical, and Radiologic Agents. Grantsmanship. Informed Consent and the Protection of Human Research Subjects: Historical Perspectives and Guide to Current United States Regulations. Animal Care and Maintenance. Funding Strategies and Agencies: Academic-Industrial Relationships; Intellectual Property. Statistical Considerations. Use of Nonexperimental Studies to Evaluate Surgical Procedures and Other Interventions: The Challenge of Risk Adjustment. Measuring Surgical Outcomes. Design of Clinical Trials. Using Administrative Data for Clinical Research. Research in the Intensive Care Unit: Ethical and Methodological Issues. Research in the Operating Room. Effects of Age and Gender. Strategies, Principles, and Techniques Using Transgenic and Knockout Mouse Models. Tissue Culture, Cell Growth, and Analysis. Hematopoietic Stem Cells: Basic Concepts and Applications to Surgical Research. Base Molecular Biological Methods in Surgical Research: Genetic Library Construction, Screening, and DNA Sequencing. Transcription. Signal Transduction and Apoptosis. Mechanisms and Regulation of Eukaryotic Protein Synthesis. Organelle Studies: Mitochondria, Golgi, and Endoplasmic Reticulum. Membrane Biology and Biophysics. Molecular Epidemiology: Beyond Gene Discovery to Clinical Diagnostic Tools. Shock Models: Hemorrhage. Scoring Systems for Trauma Research. Blunt Trauma Models: Fractures, Chest


No. of pages:
© 2001
Academic Press
Print ISBN:
Electronic ISBN:

About the authors

Wiley Souba

Affiliations and Expertise

Penn State College of Medicine, Hershey Medical Center, Pennsylvania, U.S.A.

Douglas Wilmore

Affiliations and Expertise

Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts, U.S.A.


@qu:"The editors have brought together nearly 200 authors, whose bibliography represents a 'who's who' of North American academic surgery. With this large faculty the editors have crafted 100 chapters, yet they have brought a uniformity of style and presentation that makes for easy reading. ...This is an important text. It is simply a must for every academic surgical department and a useful aid for every surgical trainee embarking on a research project. The time taken to read it is well spent and will be rewarded with time saved exploring blind alleys." @source:--P.R. O'Connell, Mater Private Hospital, in BRITISH JOURNAL OF SURGERY (February 2002) @qu:"This book is a novel and important contribution. Its greatest value will certainly be to young surgical investigators. In this book, they will not only find encouragement and reinforcement for their own hard efforts but an extensive resource for technical starting points as well as advice regarding the research process. I know of no comparable book." @source:--DOODY'S PUBLISHING REVIEWS (February 2002) @qu:"...a truly incredible book. ...the most comprehensive manual on surgical research on the market. ...There is currently no other book like it. ...I cannot understate the importance of this impressive manual. In my opinion, Surgical Research is the most outstanding book to be published in a long time. Every academic surgeon should have a copy of this book on his or her shelf. ...this book should be required reading for all surgical residents." @source:--Herbert Chen, U of Wisconsin, Dept of Surgery, in ANNALS OF SURGERY (July 2001) @qu:"The book stands alone as a reference for those beginning in research, whether they are surgeons or not. A wide range of material is brought together in a single place for easy reference. ...Each chapter is written by a seasoned investigator and stands alone as a unique reference source for o