
Surgery of the Thyroid and Parathyroid Glands
Expert Consult Premium Edition - Enhanced Online Features and Print
Free Global Shipping
No minimum orderDescription
Bringing together more than over 120 expert contributors from otolaryngology, general surgery, endocrinology, and pathology, Surgery of the Thyroid and Parathyroid Glands, 3rd Edition, presents an interdisciplinary approach to surgical management and treatment of benign and malignant disease. This renowned text/atlas is an ideal resource at all levels of surgical experience: for residents and junior surgeons, it clearly provides all relevant anatomy, surgical procedures, and workup; for experienced surgeons, it details the management of difficult cases, including revision surgery. Highly illustrated and accompanied by dozens of videos, this edition brings you up to date with the full continuum of care in thyroid and parathyroid surgery.
Table of Contents
- Cover image
- Title page
- Table of Contents
- Copyright
- Dedication
- Contributors
- Foreword to the Second Edition
- Foreword
- Preface
- Acknowledgments
- Video Contents
- Section 2 Benign Thyroid Disease
- Section 3 Preoperative Evaluation
- Section 4 Thyroid Neoplasia
- Section 5 Thyroid and Neck Surgery
- Section 6 Postoperative Considerations
- Section 7 Postoperative Management
- Section 8 Parathyroid Surgery
- Half Title
- Section 1: Introduction
- Introduction
- 1: History of Thyroid and Parathyroid Surgery
- The early years
- The surgical revolution
- Development of modern thyroid surgery
- Laryngeal nerves
- Parathyroid glands
- Historical vignette of endocrine surgery at the massachusetts general hospital
- Summary
- 2: Applied Embryology of the Thyroid and Parathyroid Glands
- Acknowledgment
- The Thyroid Gland
- The Recurrent Laryngeal Nerve
- Superior Laryngeal Nerve
- Applied Embryology of the Parathyroid Glands
- 3: Thyroid Physiology and Thyroid Function Testing
- Thyroid physiology
- Diagnostic thyroid testing
- Evaluation of hypothyroidism
- Evaluation of hyperthyroidism
- Thyroid function testing in pregnancy
- Conclusions
- Section 2: Benign Thyroid Disease
- Introduction
- 4: Thyroiditis
- Introduction
- Hashimoto’s thyroiditis (chronic lymphocytic thyroiditis)
- Subacute thyroiditis (de quervain’s thyroiditis)
- Sporadic silent and postpartum thyroiditis
- Drug-induced thyroiditis
- Acute suppurative/infectious thyroiditis
- Invasive fibrous thyroiditis (riedel’s thyroiditis)
- Chronic infectious thyroiditis
- Radiation-associated thyroiditis
- Palpation thyroiditis
- 5: Thyroglossal Duct Cysts and Ectopic Thyroid Tissue
- Embryology
- Thyroglossal Duct Cysts
- Ectopic Thyroid Tissue
- 6: Surgery of Cervical and Substernal Goiter
- General Considerations
- Anterior Mediastinal Goiter (Substernal Goiter Type I)
- Posterior Mediastinal Goiter (Substernal Goiter Type II)
- Isolated Mediastinal Goiter (Substernal Goiter Type III)
- Prevalence, Pathogenesis, and Natural History
- Clinical Presentation
- Goiter Workup
- Evaluation of Upper Airway Compromise and Other Regional Symptoms
- Treatment Options
- Intubation of the Goiter Patient and Laryngeal Edema
- Goiter Surgery
- Surgical Technique for Goiter
- Postoperative Complications of Goiter Surgery
- Recurrent Goiter: Prevention and Treatment
- 7: Approach to the Mediastinum: Transcervical, Transsternal, and Video-Assisted
- Indications
- Surgical approaches to the mediastinum
- Video-assisted thoracoscopy
- Summary
- 8: Surgical Management of Hyperthyroidism
- Introduction
- Graves’ Disease
- Toxic Nodular Goiter
- Toxic Multinodular Goiter
- Solitary Toxic Nodule
- 9: Reoperation for Benign Thyroid Disease
- Introduction
- Epidemiology
- Clinical Presentation of Recurrent Nodular Goiter
- Development of Contralateral Disease after Previous Lobectomy
- Initial Inadequate Partial Resection or Enucleation for Nodular Goiter
- Initial Bilateral Subtotal Procedure for Multinodular Goiter
- Recurrent Disease in an Embryologic Remnant after Total Thyroidectomy
- Underlying Aggressive Benign Nodular Disease Causing Recurrence
- Preoperative Evaluation
- Operative Strategy
- Postoperative Complications
- Postoperative Management and Prevention of Further Recurrence
- Management of Recurrent Graves’ Disease
- Conclusion
- Section 3: Preoperative Evaluation
- Introduction
- 10: The Evaluation and Management of Thyroid Nodules
- Introduction
- Risk factors for nodules and malignancy
- Signs, symptoms, and physical examination
- Laboratory testing
- Screening for thyroid nodules
- Incidentally found thyroid nodules
- Ultrasound evaluation for known or suspected thyroid nodules
- Evolving imaging modalities
- Size, growth pattern, and multinodularity
- Cervical lymph nodes
- Thyroid nodule risk stratification
- Fine needle aspiration, bethesda classification, and molecular testing
- Management of thyroid nodules
- Conclusion
- 11: Fine-Needle Aspiration of the Thyroid Gland: The 2017 Bethesda System
- Introduction
- Indications for Thyroid FNA
- FNA Technique
- Accuracy of Thyroid FNA
- Reporting Terminology: The Bethesda System
- Nondiagnostic Thyroid Aspirates
- Benign Conditions
- Atypia of Undetermined Significance or Follicular Lesion of Undetermined Significance
- Suspicious for A Follicular Neoplasm/Follicular Neoplasm: Follicular Adenomas and Follicular Carcinomas
- Hürthle Cell Neoplasms
- Malignant Tumors
- Thyroid FNA Complications
- 12: Fine-Needle Aspiration and Molecular Analysis
- Introduction
- Principles of Molecular Testing
- ThyroSeq®
- AFIRMA® Expression Classifier
- Gene Sequencing Classifier
- ThyGeNext®-ThyraMIR®
- Choosing a Molecular Test
- Illustrative Cases
- Future Applications
- Conclusion
- 13: Ultrasound of the Thyroid and Parathyroid Glands
- Introduction
- Physics and Principles of Ultrasound
- Thyroid Ultrasound
- Ultrasound Characteristics of Malignant Lesions
- Ultrasound-Guided Thyroid Procedures
- Sonography of Neck Nodes
- Parathyroid Ultrasound
- Summary
- 14: Preoperative Radiographic Mapping of Nodal Disease for Papillary Thyroid Carcinoma
- Macroscopically Positive Versus Microscopically Positive Metastasis
- Importance of Radiographic Detection of Macroscopically Positive Nodes PrEoperatively
- Central Neck Nodes
- Lateral Neck Nodes
- Preoperative Radiographic Evaluations: Ultrasounds and Cat Scans
- Physical Examination
- Ultrasound
- CT Scanning with Contrast
- Combination of CT Scan and Ultrasound
- 15: Laryngeal Examination in Thyroid and Parathyroid Surgery
- Introduction
- Anatomy and the voice
- Reported prevalence of recurrent laryngeal nerve paralysis
- Glottic examination and the voice
- Voice symptoms with normal vocal fold mobility
- Vocal cord paralysis without voice symptoms
- Rationale for preoperative laryngeal examination
- Laryngeal examination guidelines
- Rationale for postoperative laryngeal examination
- Flexible laryngoscopy: a standard technique to be mastered by all thyroid surgeons
- Summary
- 16: Radiofrequency and Laser Ablation of Thyroid Nodules and Parathyroid Adenoma
- Introduction
- Radiofrequency Ablation
- Follow-Up Evaluation
- Laser Ablation
- Autonomously Functioning Thyroid Nodules
- Alternative Therapies
- Parathyroid Tumors
- Future Perspectives
- Conclusion
- Section 4: Thyroid Neoplasia
- Introduction
- 17: Differentiated Thyroid Cancer Incidence
- Incidence of Differentiated Thyroid Cancer
- Overview of Current Incidence Rates
- Recent Trends in the Incidence of Differentiated Thyroid Cancer
- Mortality Trends of Differentiated Thyroid Cancer
- The Effect of the Increased Incidence of Thyroid Cancer
- Managing the Increasing Incidence of Thyroid Cancer
- Conclusions and next steps
- 18: Molecular Pathogenesis of Thyroid Neoplasia
- Introduction
- Thyroid Cancer Epidemiology
- Pathology
- Thyroid Cancer Prognosis
- Germline Genetics of Thyroid Cancer
- Somatic Genomics of Thyroid Cancer
- Clinical Implications of the Somatic Genomic Data
- Conclusions
- 19: Papillary Thyroid Cancer
- Introduction
- Epidemiology
- Factors that may Contribute to Thyroid Cancer Risk
- Factors Influencing Prognosis
- Initial Treatment of Papillary Thyroid Cancer
- Response to Therapy
- Long-Term Management and Surveillance
- 20: Papillary Thyroid Microcarcinoma
- Prevalence: Autopsy Series and Incidental Finding at the Time of Thyroid Surgery
- Clinical Incidence and Prevalence
- Clinical Series of Patients with Micropapillary Cancer
- Observational Data and Active Surveillance
- Impact of Initial Surgery
- Completion Thyroidectomy
- Node Dissection
- Radioiodine
- Braf
- Postoperative Surveillance
- Summary and Recommendations
- 21: Papillary Carcinoma Observation
- Introduction
- Disease Progression During Active Surveillance of Low-Risk Papillary Thyroid Cancer
- Clinical Framework for an Active Surveillance Management Strategy
- Indications to Move from Active Surveillance to Surgical Intervention
- Active Surveillance: Practical Application
- Research Needs
- Conclusion
- 22: Follicular Thyroid Cancer
- Introduction
- Epidemiology
- Etiology
- Diagnosis
- Treatment
- Prognosis
- Summary
- 23: Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features (NIFTP)
- Introduction
- Definition
- Epidemiology
- Etiology
- Diagnosis
- Treatment
- Prognosis
- Summary
- 24: Dynamic Risk Group Analysis and Staging for Differentiated Thyroid Cancer
- Introduction
- Initial Risk Stratification
- Response to Therapy Assessment
- Integrating Initial Risk Estimates with Response to Therapy (Dynamic Risk Assessment)
- Representative Case Example
- Predicting Clinical Outcomes Using Response to Therapy Variables Superimposed on Initial ATA Risk Stratification
- Summary
- 25: Hürthle Cell Tumors of the Thyroid
- Introduction
- Pathology
- Presentation and Natural History
- Genetics of Hürthle Cell Tumors
- Staging and Prognostic Factors
- Preoperative Evaluation
- Surgery
- Hürthle Adjuvant Therapy
- Follow-Up
- Summary
- 26: Sporadic Medullary Thyroid Carcinoma
- Introduction
- Pathophysiology
- Genetics: Sporadic Versus Hereditary
- Diagnostic Considerations, Workup, and Staging
- Primary Surgical Treatment
- Follow-Up and Surveillance
- Surgical Management of Recurrent Disease
- Radiation Therapy for MTC
- Distant Metastatic Disease and Systemic Therapy for MTC
- Conclusion
- 27: Syndromic Medullary Thyroid Cancer: MEN 2A and MEN 2B
- Introduction
- Clinical Presentation by Genotype
- Evaluation of Gene Carriers for Surgery
- Surgery
- Conclusion
- 28: Anaplastic Thyroid Cancer and Primary Thyroid Lymphoma
- Introduction
- Evaluation of a Patient with Rapidly Enlarging Neck Mass
- Pathologic Evaluation of a Rapidly Growing Neck Mass
- Anaplastic Thyroid Cancer
- Clinical Course and Prognosis
- Radiotherapy
- Primary Thyroid Lymphoma
- 29: Pediatric Thyroid Cancer
- Introduction
- Etiology
- Pathology
- Genetics
- Presentation and Preoperative Evaluation
- Treatment
- Surgical Management of FTC
- Surgical Management of MTC
- Radioactive Iodine Therapy for Children with Thyroid Cancer
- Summary
- 30: Familial Nonmedullary Thyroid Cancer
- Introduction
- Epidemiology
- Classification of Familial Disease
- Clinical Features
- Tumor Histology
- Genetics of FNMTC
- Screening and Surveillance
- Treatment
- Prognosis/Outcome
- Summary
- Section 5: Thyroid and Neck Surgery
- Introduction
- 31: Principles in Thyroid Surgery
- Introduction
- Extent of Thyroidectomy
- Extent of Surgery Based on Fna Result
- Nomenclature of Thyroidectomy
- Thyroidectomy Surgical Steps
- 32: Robotic and Extracervical Approaches to the Thyroid and Parathyroid Glands
- Introduction
- Patient Selection, Indications, and Contraindications
- Surgical Technique
- Postoperative Care
- Conclusions
- 33: Transoral Thyroidectomy
- History of Transoral Thyroidectomy
- Better Cosmetic RESULTS are a Natural Outcome of Process Improvement
- Remote-Access Thyroid Surgery is more Popular in Asia Than in the Western World?
- Why Offer Remote Access Thyroid Surgery at All?
- TransOral Thyroid Surgery (TOTS) Versus Other Remote Access Approaches
- Patient Selection and Contraindications
- Preoperative Workup
- Technique
- Outcomes
- Future directions
- 34: Minimally Invasive Video-Assisted Thyroidectomy
- Introduction
- Indications
- Instruments
- Surgical Technique
- Personal Experience
- Minimally Invasive Video-Assisted Neck Dissection
- 35: Surgical Anatomy and Monitoring of the Superior Laryngeal Nerve
- History
- Anatomy
- Physiology and Pathophysiology
- Surgical Technique
- Diagnosis of EBSLN Paralysis
- IBSLN Monitoring
- Conclusion
- 36: Surgical Anatomy and Monitoring of the Recurrent Laryngeal Nerve
- Introduction
- Surgical Anatomy
- Visual Appearance
- Surgical Approaches to the RLN
- RLN Surgical Dissection Tips and Pitfalls
- RLN Monitoring
- IONM Setup and Standards
- Continuous Neural Vagal Monitoring (C-IONM)
- Management of Infiltrated Nerve
- Management of Neural Injury
- Vocal Cord Recovery: Timing and Assessment
- SLN Monitoring
- 37: Surgery for Locally Advanced Thyroid Cancer: Larynx, Tracheal Invasion, and Esophageal
- Signs and Symptons of Invasive Thyroid Cancer
- Imaging
- Mechanism for Visceral Invasion by Thyroid Cancer
- Surgical Management
- Management of The Recurrent Laryngeal Nerve in Invasive Thyroid Cancer
- Tracheal Invasion
- Laryngeal Invasion
- Cricoid Invasion
- Advanced Laryngeal Invasion
- Esophageal Invasion
- Conclusion
- 38: Central Neck Dissection: Indications and Technique
- Introduction
- Anatomy
- Terminology
- Therapeutic Central Lymph Node Dissection
- Elective/Prophylactic Central Neck Dissection
- Summary of Indications
- Preoperative Evaluation
- Surgical Technique
- Bilateral Paratracheal Dissection
- 39: Lateral Neck Dissection: Indications and Technique
- Anatomy of the Neck
- Thyroid Gland Lymphatics
- Risk Factors for Lymph Node Metastases
- Lymph Node Metasis and its Effect on Disease Outcome
- Management of the N0 Lateral Neck in Differentiated Thyroid Cancer
- Management of the N0 Lateral Neck in Medullary Thyroid Cancer
- Management of the N+ Lateral Neck
- Radioactive Iodine for Nodal Metastases
- Types of Neck Dissection
- Technique
- Closure and Postoperative Care
- Complications
- 40: Incisions in Thyroid and Parathyroid Surgery
- Introduction
- Historical Perspectives
- General Principles
- Specific Procedure Considerations
- Best Practices
- 41: Surgical Pathology of the Thyroid Gland
- Introduction
- Benign Neoplasms: Adenomas and Adenomatous Nodules
- Variants of Follicular Adenoma
- Malignant Neoplasms
- Papillary Carcinoma
- Variants of Papillary Cancer
- Immunohistochemistry of Papillary Carcinoma
- Follicular Carcinoma
- Molecular Pathology of Follicular Carcinoma
- Well-Differentiated Follicular “Tumors of Undetermined/Uncertain Malignant Potential”
- Hürthle cell / Oncocytic Follicular Tumors
- “High-Grade” Thyroid Carcinomas
- Poorly Differentiated Carcinoma
- Anaplastic Carcinoma
- Follicular-Derived Familial Tumors
- Medullary Carcinoma
- Tumors with Thymic or Related Branchial Pouch Differentiation
- Mucoepidermoid Carcinoma of Thyroid Gland
- Primary Nonepithelial Tumors of Thyroid
- Carcinoma in Thyroglossal Duct Cyst and Ectopic Thyroid Tissue
- Pathologist and Thyroid
- Intraoperative Assessment of Thyroid Nodules
- Gross Examination of Thyroid Specimens
- Histopathologic Reporting of Thyroid Tumors
- Section 6: Postoperative Considerations
- Introduction
- 42: Pathophysiology of Recurrent Laryngeal Nerve Injury
- Introduction
- Variations in Symptoms
- Configuration of the Paralyzed Vocal Fold
- Biology of Nerve Injury and Regeneration
- Mechanisms of Intraoperative Laryngeal Nerve Injury
- Why are Vocal Folds Immobile Despite Reinnervation?
- Muscle Compartments and Laryngeal Motion
- Preferential Reinnervation
- Acute Management of the Transected Nerve
- Summary
- 43: Management of Recurrent Laryngeal Nerve Paralysis
- Introduction
- Unilateral Vocal Fold Paralysis
- Management of Unilateral Vocal Fold Paralysis
- Bilateral Vocal Fold Immobility
- Summary
- 44: Nonneural Complications of Thyroid and Parathyroid Surgery
- Introduction
- Hypoparathyroidism
- Hypothyroidism
- Thyrotoxic Storm
- Hemorrhage and Hematoma
- Hypertrophic Scar
- Seroma
- Infection
- Aerodigestive Tract Injury
- Airway Complications
- Methylene Blue
- Rare Complications
- Mortality
- 45: Quality Assessment in Thyroid and Parathyroid Surgery
- History of Quality Improvement in Medicine
- Defining Quality
- Measuring Quality
- Improving Quality
- Future Directions
- Conclusion
- 46: Ethics and Malpractice in Thyroid and Parathyroid Surgery
- Ethical Issues
- The Surgeon’s Responsibility
- Malpractice Issues
- Conclusions
- Section 7: Postoperative Management
- Introduction
- 47: Postoperative Management of Differentiated Thyroid Cancer
- Goals of Postoperative Management
- Treatment According to Risk of Cancer Recurrence
- Dynamic Risk Assessment
- Follow-Up
- Prognosis
- Treatment of Distant Metastases
- Conclusion
- 48: Postoperative Radioactive Iodine Ablation and Treatment of Differentiated Thyroid Cancer
- Introduction
- Why RAI Therapy For Thyroid Cancer Management?
- Selective Use of RAI Therapy
- Role of Postoperative Disease Assessment
- Postoperative Use of Rai Therapy Using a Selective Use Approach
- Thyroid Hormone Withdrawal Versus Recombinant Thyroid-Stimulating Hormone
- Choice of Administered RAI Activity Based on Clinicopathologic Presentation
- Conclusion
- 49: External Beam Radiotherapy for Thyroid Malignancy
- Introduction
- Differentiated Thyroid Cancer
- Medullary Thyroid Cancer
- Anaplastic Thyroid Cancer
- Treatment of Metastatic Disease
- Lymphoma
- Indolent (Low-Grade) Lymphomas
- Aggressive Histology Lymphomas
- External Beam Radiotherapy Technique
- Toxicity From External Beam Radiotherapy
- 50: Reoperative Thyroid Surgery
- Introduction
- Indications for Revision Surgery
- Routine Postoperative Surveillance
- Management Options
- Surgical Management
- Reoperative Surgery: Completion Thyroidectomy
- Reoperative Surgery: Central Neck Dissection-Paratracheal and Superior Mediastinal Dissection
- Conclusion
- 51: Nonsurgical Treatment of Thyroid Cysts, Nodules, Thyroid Cancer Nodal Metastases, and Hyperparathyroidism: The Role of Percutaneous Ethanol Injection
- Introduction
- General Principles of us-Guided Percutaneous Ethanol Injection of Cysts and Tumors
- Ultrasonography Imaging Anatomy of Head and Neck
- Etiologies Amenable to pei in Head and Neck Endocrine Tumors
- The procedure of Cyst Injection
- Outcomes of PEI in Cystic and Predominantly Cystic Nodules
- The procedure of Alcohol Injection into Solid Nodules
- Alcohol Ablation of Malignant Metastatic Lymphadenopathy in Thyroid Cancer
- Techniques, Materials Used, and Practical Considerations
- Cost Effectiveness of PEI for Metastatic Lymphadenopathy
- Percutaneous Ethanol Injection of Parathyroid Adenoma and Hyperplasia
- Risks and Side Effects of Alcohol Injection
- Strategies for Reducing Risk of Ethanol Extravasation and Related Tissue Damage
- Procedure Suite Safety Policies, Complication Recognition and Mitigation
- Summary and Conclusions
- 52: Medical Treatment Horizons for Metastatic Differentiated and Medullary Thyroid Cancer
- Introduction
- Differentiated Thyroid Cancer Subtypes
- Medullary Thyroid Carcinoma
- Section 8: Parathyroid Surgery
- Introduction
- 53: Primary Hyperparathyroidism: Pathophysiology, Surgical Indications, and Preoperative Workup
- Clinical Presentations of Primary Hyperparathyroidism
- Epidemiology of PHPT
- Skeleton
- Bone Densitometry
- Bone Histomorphometry
- Fractures
- Nephrolithiasis
- Other Organ Involvement
- Normocalcemic Primary Hyperparathyroidism
- Pathology
- Clinical Course with and Without Surgery
- Surgery
- Medical Management
- Diagnosis and Course of Normocalcemic Primary Hyperparathyroidism
- Drug Treatment
- Calcimimetic Agents
- Unusual Presentations
- Parathyroid Cancer
- 54: Guide to Preoperative Parathyroid Localization Testing
- Introduction
- Localization Studies
- Unique Scenarios
- Algorithms For First-Time Operations and Recurrent/Persistent Disease
- Conclusion
- 55: Principles in Surgical Management of Primary Hyperparathyroidism
- Preoperative Evaluation
- Vitamin D and Primary Hyperparathyroidism
- Normocalcemic Primary Hyperparathyroidism
- Localization Testing
- Uniglandular Versus Multiglandular Disease
- Asynchronous Multiglandular Disease
- Intraoperative PTH: Functional Criteria for Uniglandular Versus Multiglandular Disease
- Histology
- Molecular Genetics of Primary Hyperparathyroidism
- Parathyroid Surgical Anatomy
- Embryologic Variation
- Locations of Missed Adenomas Based on Reoperative Series
- Intrathyroidal Adenoma
- Thyroidectomy During Parathyroidectomy
- Parathyroid Exploration: Surgical Technique
- Mediastinal Adenoma
- Surgical Technique for Multiglandular Disease
- Parathyroid Surgery Failure
- Surgical Controversies
- Postoperative Assessment
- 56: Standard Bilateral Parathyroid Exploration
- Anatomy and Embryology Relevant for Bilateral Parathyroid Exploration
- The Rationale for Bilateral Parathyroid Exploration
- Preoperative Planning: Parathyroid Localization Studies
- Surgical Technique of Bilateral Parathyroid Exploration
- Strategy for Finding the “Missing” Parathyroid
- Postoperative Management
- Special Considerations in Bilateral Parathyroid Exploration
- Summary
- 57: Minimally Invasive Single Gland Parathyroid Exploration
- Background
- Considerations for Performing MIP
- A Standard Parathyroid Nomenclature System
- Preoperative Imaging and Localization
- Operative Preparation and Techniques
- Postoperative Care and Follow-up
- 58: Minimally Invasive Video-Assisted Parathyroidectomy
- Introduction
- Preoperative Localization Studies
- Intraoperative PTH Assay
- Minimally Invasive Parathyroidectomy
- Techniques for MIP
- MIP: Evidence-Based Recommendations
- 59: Intraoperative PTH Monitoring During Parathyroid Surgery
- Introduction
- History of Intraoperative PTH Monitoring
- Which Patients Benefit from IPM-Guided Parathyroidectomy?
- Intraoperative PTH Monitoring as an Adjunct During Parathyroidectomy
- IPM Protocol for Intraoperative Blood Sampling
- Intraoperative Scenarios and Troubleshooting
- Intraoperative Criteria in Predicting Operative Success
- Limitations of Intraoperative PTH Monitoring with the “> 50% PTH Drop” Criterion
- Results of Parathyroidectomy Guided by IPM
- Other Applications for Intraoperative Rapid PTH Assays
- Summary
- 60: Surgical Management of Multiglandular Parathyroid Disease
- Definition and Incidence
- Macroscopic and Microscopic Pathology of Abnormal Glands
- Histopathological Criteria for Adenoma and Hyperplasia
- Extent of Parathyroid Exploration and Diagnosis of MGD
- Tumor Clonality in Uniglandular and Multiple Gland Disease
- Etiology and Risk Factors for MGD
- Preoperative Diagnosis of MGD
- Intraoperative Adjuncts in MGD
- Surgical Treatment
- Operative Strategy in Localized Disease (Unilateral Exploration/Lateral Approach)
- 61: Surgical Management of Secondary and Tertiary Hyperparathyroidism
- Secondary Hyperparathyroidism
- Tertiary Hyperparathyroidism
- 62: Parathyroid Management in the MEN Syndromes
- Multiple Endocrine Neoplasia (Men) Type 1
- Genetic Testing in Men 1
- Men 1–Associated Hyperparathyroidism
- Indications for Surgery
- Surgical Treatment of Men 1–Associated Hpt
- Treatment of Persistent or Recurrent Men 1–Associated Phpt
- Multiple Endocrine Neoplasia Type 2a
- Genetic Testing in Men 2a
- Men 2a–Associated Phpt
- Indications for Surgery
- Surgical Treatment of Men 2A–Associated Phpt
- Treatment of Persistent or Recurrent Men 2a–Associated Phpt
- Use of Intraoperative Adjuncts During Parathyroidectomy for Men–Associated Phpt
- Nonsurgical Management of Persistent or Recurrent Men–Associated Phpt
- Conclusions
- 63: Revision Parathyroid Surgery
- Introduction
- Why?
- Who?
- When?
- How?
- Common Reoperative or Challenging Primary Operative Scenarios
- Summary
- 64: Parathyroid Carcinoma
- Background
- Risk Factors and Etiology
- Clinical Presentation
- Histopathology
- Preoperative Management
- Resection of Recurrence
- Genetic Testing
- Outcome and Prognosis
- Summary
- 65: Surgical Pathology of the Parathyroid Glands
- Development and Anatomy
- Hyperparathyroidism
- Primary Hyperparathyroidism
- Parathyroid Carcinoma
- Primary Chief Cell Hyperplasia
- Other Familial Hyperparathyroidism Syndromes
- Other Familial Hyperparathyroidism Syndromes
- Cysts
- Cysts
- Secondary Tumors
- Secondary Tumors
- Hypoparathyroidism
- Hypoparathyroidism
- Index
Product details
- No. of pages: 656
- Language: English
- Copyright: © Elsevier 2020
- Published: March 14, 2020
- Imprint: Elsevier
- eBook ISBN: 9780323661287
- Hardcover ISBN: 9780323661270
About the Author
Gregory Randolph
Affiliations and Expertise
Gregory W. Randolph MD FACS FACE FEBS (Endocrine), Professor of Otolaryngology Head and Neck Surgery, Claire and John Bertucci Endowed Chair in Thyroid Surgical Oncology, Harvard Medical School, Chief Thyroid/Parathyroid Endocrine Surgical Division, Massachusetts Eye and Ear Infirmary Member Endocrine Surgical Service, Massachusetts General Hospital, Boston, Massachusetts, USA
Ratings and Reviews
There are currently no reviews for "Surgery of the Thyroid and Parathyroid Glands"