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Surface and Interface Analysis in Pharmaceutical and Biopharmaceutical Fields
1st Edition - March 1, 2019
Author: Xia Dong
Hardback ISBN:
9 7 8 - 0 - 1 2 - 8 0 4 0 2 3 - 2
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 0 4 1 0 0 - 0
Surface and Interface Analysis in Pharmaceutical and Biopharmaceutical Fields provides a comprehensive review of the most commonly used interface science techniques in drug… Read more
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Surface and Interface Analysis in Pharmaceutical and Biopharmaceutical Fields provides a comprehensive review of the most commonly used interface science techniques in drug research and development (including their capabilities and limitations) and relates them to a specific, practical situation. This book outlines sample preparation crucial for a successful outcome and features methods to interpret results that can be combined with other techniques. It provides engineers who work in instrument companies a comprehensive understanding of the specific challenges faced by these techniques in pharmaceutical/biopharmaceutical applications, presenting a framework for new instruments that can be designed to address current challenges.
- Provides diagrams of drug development roadmaps
- Includes snapshots of potential applications of surface and interface characterization at each stage of drug development
- Summarizes major surface/interface characterization techniques
- Compares the pros and cons of commonly applied surface/interface characterization techniques
- Explores working examples from pharmaceutical and biopharmaceutical fields
- Guides the development of practical strategies for solving real-world problems
Surface scientists, analytical chemists, drug discovery and formulation scientists, packaging and device engineers, manufacturing engineers, instrument designers working in research and development in academia, government, and pharmaceutical industries
1. Introduction to small molecule drug product development2. Introduction to bioproduct development3. Introduction to packaging and device development4. Principals of surface and interface characterization techniques5. Methodology for surface and interface analysis of pharmaceutical and biopharmaceutical samples6. Applications of surface characterization techniques in drug discovery7. Applications of surface and interface characterization techniques in small molecule drug product development8. Applications of surface and interface characterization techniques in bioproduct development9. Applications of surface and interface characterization techniques in packaging and injectable device development10. Failure analysis and root cause investigation for manufacturing deviation and complaint samples11. Current challenges and future trends
- No. of pages: 460
- Language: English
- Edition: 1
- Published: March 1, 2019
- Imprint: Elsevier
- Hardback ISBN: 9780128040232
- eBook ISBN: 9780128041000
XD
Xia Dong
Xia Dong is a Principal Research Scientist at Eli Lilly and Company and serves as the leader of surface and polymer science group. Xia obtained a B.S. degree in Analytical Chemistry from University of Science and Technology in China (USTC), and a Ph.D. in Analytical Chemistry from University of Pittsburgh. She served as a surface scientist in Evans East from 1998, before joining Lilly in 2003. At Lilly, she leads materials characterization efforts to develop applications of surface analysis, polymer characterization, and imaging techniques in the product development area. Her research focuses on the integration of multiple techniques including TOF-SIMS, XPS, ellipsometry, AFM, NIR and micro-CT to enhance the understanding of properties of drug substances, excipients, packaging materials, and their interactions. Her group also provides analytical support to investigations of manufacturing deviations, complaint samples, counterfeit samples, and patent infringement. Xia has key interest in expanding the application of surface and interface characterization in pharmaceutical industry. She proposed and co-organized the symposium “Surface & Interface Sciences in Biological & Pharmaceutical Fields” at 246th ACS National Meeting, and was elected as member at large of Applied Surface Science Division at the American Vacuum Society.
Affiliations and expertise
Principal Research Scientist, Surface and Polymer Science Group, Eli Lilly and Company, Carmel, IN, USA