Supramolecular Enzyme Organization

Supramolecular Enzyme Organization

Quaternary Structure and Beyond

1st Edition - January 1, 1984

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  • Author: Peter Friedrich
  • eBook ISBN: 9781483147833

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Supramolecular Enzyme Organization: Quaternary Structure and Beyond provides a comprehensive discussion of enzyme interactions. It attempts to place conceptually related phenomena in a common perspective by first scrutinizing enzyme interactions at the quaternary level and then moving on towards higher orders of organization. The book begins with a discussion of the hierarchy of enzymes, covering the structure of monomeric enzymes, enzyme structures beyond the monomeric stage, and protein-protein interactions. Separate chapters cover the chemistry of protein associations; the quaternary structure of enzymes; multienzyme systems; multienzyme complexes and conjugates; the association of enzymes with cellular structures; and metabolite compartmentation. The final chapters discuss trends in the study of enzyme systems and the dialectics of enzymology. This book is intended, not for the specialist, who knows much more about the individual questions than the text offers, but rather for the general biochemical reader interested in enzyme organization. There is practically no mathematics involved. Instead, quite elementary things are described, so that students and biologists with less background knowledge on enzymes will be able to join in.

Table of Contents

  • List of Abbreviations

    Chapter 1. The Hierarchy of Enzyme Structures

    Structure of Monomeric Enzymes

    Enzyme Structures Beyond the Monomeric Stage

    The Conceptual Framework of Protein-Protein Interactions

    Chapter 2. Chemistry of Protein Associations

    The Concept of Complementary Surfaces

    Complementary Protein Surfaces are Tightly Packed

    About the Predominant Role of Hydrophobic Interactions

    Electrostatic Effects Mainly Contribute to the Specificity of Protein Associations

    Chapter 3. Intramolecular Organization: The Quaternary Structure of Enzymes

    Oligomeric Enzymes

    Number of Subunits in Oligomeric Enzymes

    Subunit Arrangements in Oligomeric Enzymes

    Biological Roles of Oligomeric Structure

    Quaternary Structure and Enzyme Activity

    Quaternary Structure and Protein Stability

    Quaternary Structure and Enzyme Regulation

    Complex Enzymes

    Regulation Through non-Catalytic Subunits

    Chapter 4. Intermolecular Organization: Multienzyme Systems

    Functional vs. Structural Organization

    Functional Consequences of Enzyme Juxtaposition

    Proximity Effect

    Activation of Physiological and Suppression of non-Physiological Reactions

    Coordinate Regulatory Effects

    Chapter 5. Multienzyme Complexes and Conjugates

    Stable Multienzyme Complexes

    Tryptophan Synthase

    The α-Ketoacid Dehydrogenase Multienzyme Complexes

    Interconvertible Enzymes and Enzyme Cascades

    Multienzyme Conjugates

    The Arom Multienzyme Conjugate

    Fatty Acid Syntheses from Animal Tissues

    The Initiation of Pyrimidine Biosynthesis: The Cluster of Carbamoyl-P Synthase-aspartate Carbamoyl Transferase-Dihydroorotase

    "Complex U": The Terminator of Pyrimidine Biosynthesis

    Aspartokinase I: Homoserine Dehydrogenase I

    Other Multienzyme Conjugates

    Multienzyme Complex-Conjugates

    Fatty Acid Synthase from Yeast

    Interactions between "Soluble" Enzymes

    Interactions of Glycolytic Enzymes

    Interactions between Enzymes of the Mitochondrial Matrix

    Chapter 6. Association of Enzymes with Cellular Structures

    Enzymes Incorporated into Structures

    Integral Membrane Enzymes

    Enzymes Loosely Bound to Structures

    Glycolytic Enzymes and the Contractile Apparatus

    Glycolysis and the Erythrocyte Membrane

    The "Glycosome"

    Hexokinase and the Mitochondrial Membrane

    Theoretical Models of Enzyme Regulation by Reversible Adsorption

    Chapter 7. Metabolite Compartmentation

    The Cell as Basic Compartment

    Intracellular Compartments and Metabolite Pools

    Macro-compartments: Plasmatic and non-Plasmatic

    Arginine Metabolism in Neurospora: A Case of Regulation via Macro-compartments


    Metabolite Channeling in Multienzyme Clusters

    Dynamic Compartmentation

    Heterogeneity of Metabolite Pools Due to Biding Sites

    Survey of Methods for the Detection of Metabolite Compartmentation

    Chapter 8. Current Trends in the Study of Enzyme Systems

    Mathematical Modeling of Enzyme Systems

    Study of Enzymes In Vivo

    Invasive Methods

    Non-Invasive Methods

    Systemic Approach to Metabolic Control

    Functional Complementarity between Enzymes

    Chapter 9. Enzyme Organization: Summary and Perspectives

    The Dialectics of Enzymology: Away from and Back to the Living Cell

    The Third Dimension of Metabolic Maps

    The Dividends of Complexity

    Enzyme Organization in Disease and Aging

    Enzyme Therapy

    Enzyme Technology

    Enzymology of the 21st Century


    Subject Index

Product details

  • No. of pages: 316
  • Language: English
  • Copyright: © Pergamon 1984
  • Published: January 1, 1984
  • Imprint: Pergamon
  • eBook ISBN: 9781483147833

About the Author

Peter Friedrich

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