Supramolecular Enzyme Organization - 1st Edition - ISBN: 9780080263762, 9781483147833

Supramolecular Enzyme Organization

1st Edition

Quaternary Structure and Beyond

Authors: Peter Friedrich
eBook ISBN: 9781483147833
Imprint: Pergamon
Published Date: 1st January 1984
Page Count: 316
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Supramolecular Enzyme Organization: Quaternary Structure and Beyond provides a comprehensive discussion of enzyme interactions. It attempts to place conceptually related phenomena in a common perspective by first scrutinizing enzyme interactions at the quaternary level and then moving on towards higher orders of organization.

The book begins with a discussion of the hierarchy of enzymes, covering the structure of monomeric enzymes, enzyme structures beyond the monomeric stage, and protein-protein interactions. Separate chapters cover the chemistry of protein associations; the quaternary structure of enzymes; multienzyme systems; multienzyme complexes and conjugates; the association of enzymes with cellular structures; and metabolite compartmentation. The final chapters discuss trends in the study of enzyme systems and the dialectics of enzymology. This book is intended, not for the specialist, who knows much more about the individual questions than the text offers, but rather for the general biochemical reader interested in enzyme organization. There is practically no mathematics involved. Instead, quite elementary things are described, so that students and biologists with less background knowledge on enzymes will be able to join in.

Table of Contents

List of Abbreviations

Chapter 1. The Hierarchy of Enzyme Structures

Structure of Monomeric Enzymes

Enzyme Structures Beyond the Monomeric Stage

The Conceptual Framework of Protein-Protein Interactions

Chapter 2. Chemistry of Protein Associations

The Concept of Complementary Surfaces

Complementary Protein Surfaces are Tightly Packed

About the Predominant Role of Hydrophobic Interactions

Electrostatic Effects Mainly Contribute to the Specificity of Protein Associations

Chapter 3. Intramolecular Organization: The Quaternary Structure of Enzymes

Oligomeric Enzymes

Number of Subunits in Oligomeric Enzymes

Subunit Arrangements in Oligomeric Enzymes

Biological Roles of Oligomeric Structure

Quaternary Structure and Enzyme Activity

Quaternary Structure and Protein Stability

Quaternary Structure and Enzyme Regulation

Complex Enzymes

Regulation Through non-Catalytic Subunits

Chapter 4. Intermolecular Organization: Multienzyme Systems

Functional vs. Structural Organization

Functional Consequences of Enzyme Juxtaposition

Proximity Effect

Activation of Physiological and Suppression of non-Physiological Reactions

Coordinate Regulatory Effects

Chapter 5. Multienzyme Complexes and Conjugates

Stable Multienzyme Complexes

Tryptophan Synthase

The α-Ketoacid Dehydrogenase Multienzyme Complexes

Interconvertible Enzymes and Enzyme Cascades

Multienzyme Conjugates

The Arom Multienzyme Conjugate

Fatty Acid Syntheses from Animal Tissues

The Initiation of Pyrimidine Biosynthesis: The Cluster of Carbamoyl-P Synthase-aspartate Carbamoyl Transferase-Dihydroorotase

"Complex U": The Terminator of Pyrimidine Biosynthesis

Aspartokinase I: Homoserine Dehydrogenase I

Other Multienzyme Conjugates

Multienzyme Complex-Conjugates

Fatty Acid Synthase from Yeast

Interactions between "Soluble" Enzymes

Interactions of Glycolytic Enzymes

Interactions between Enzymes of the Mitochondrial Matrix

Chapter 6. Association of Enzymes with Cellular Structures

Enzymes Incorporated into Structures

Integral Membrane Enzymes

Enzymes Loosely Bound to Structures

Glycolytic Enzymes and the Contractile Apparatus

Glycolysis and the Erythrocyte Membrane

The "Glycosome"

Hexokinase and the Mitochondrial Membrane

Theoretical Models of Enzyme Regulation by Reversible Adsorption

Chapter 7. Metabolite Compartmentation

The Cell as Basic Compartment

Intracellular Compartments and Metabolite Pools

Macro-compartments: Plasmatic and non-Plasmatic

Arginine Metabolism in Neurospora: A Case of Regulation via Macro-compartments


Metabolite Channeling in Multienzyme Clusters

Dynamic Compartmentation

Heterogeneity of Metabolite Pools Due to Biding Sites

Survey of Methods for the Detection of Metabolite Compartmentation

Chapter 8. Current Trends in the Study of Enzyme Systems

Mathematical Modeling of Enzyme Systems

Study of Enzymes In Vivo

Invasive Methods

Non-Invasive Methods

Systemic Approach to Metabolic Control

Functional Complementarity between Enzymes

Chapter 9. Enzyme Organization: Summary and Perspectives

The Dialectics of Enzymology: Away from and Back to the Living Cell

The Third Dimension of Metabolic Maps

The Dividends of Complexity

Enzyme Organization in Disease and Aging

Enzyme Therapy

Enzyme Technology

Enzymology of the 21st Century


Subject Index


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About the Author

Peter Friedrich

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