Substance Use and Addiction Research
Methodology, Mechanisms, and Therapeutics
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Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on research methodologies for substance use and addiction that is intended for researchers and consumers of research information at all levels. The book is divided into four major sections, including an Introduction, Research Methodology for clinical trials, animal research and retrospective studies, Mechanisms of Use and Addiction, and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source for addressing all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances. The book covers what is known in the field of quantitative and qualitative research methods, provides future directions, and introduces new models for investigation. It is organized around a translational science framework, with the contents addressing substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions.
Key Features
- Presents a practical, easy to read text designed to appeal to both experienced and beginner researchers in the field of substance abuse/addiction science
- Provides a concise, well-organized handbook that is a complete guide to methodologies in conducting substance abuse/addiction research
- Contains contributions from leading academic institutions
- Includes ample diagrams, tables and figures to help organize the information for easy reference, along with a list and explanation of existing useful measurement tools, websites, statistical methods and other resources
Readership
All researchers and clinician-scientists in the field of addiction science and substance abuse, including addiction counsellors, psychiatrists, psychologists, addiction medicine physicians, interventionalists, pain management specialists, and substance abuse social workers, intended for both seasoned researchers and clinicians as well as students and trainees at all levels undergraduate, graduate, post-graduate
Table of Contents
- Basics of Research Methodology
1. Reliability and validity in substance abuse and addiction research
2. Animal models
a. animal behavior principles
b. animal drug self-administration
c. drug discrimination
d. other topics in animal research
3. Translational research strategies
a. human drug administration
b. measuring drug effects
4. Experimental design in clinical trials Part 1
a. definitions, design, intervention
b. comparison conditions
5. Experimental design in clinical trials Part 2
a. target population and recruitment;
b. sample size; outcome measures
c. statistical analysis;
d. scales in addiction;
e. modes of data collection (e.g., surveys, interviews)
6. Qualitative and quantitative methods
a. theory
b. collecting and organizing data
7. Ethical issues in opioids, alcohol, other drugs and addiction-related research:
a. general ethical frameworks
b. addiction-specific ethical issues
c. ethics in other countries
d. funding related ethical issues influence research
8. Informatics
a. strategies through infrastructure
b. general concepts
9. Artificial intelligence and machine learning
10. Epidemiology and health services research methods
a. data acquisition
b. data analysis
11. Imaging
a. techniques
b. analysis
12. Systematic review and meta-analysis
Mechanisms of abuse and addiction
13. Abuse and addiction
a. definitions
b. demographics
c. general concepts
14. Assessment of addiction/pain and neurobiology
15. Physiological considerations in opioid addiction
a. normal physiology and anatomy
b. pathophysiological considerations
c. pain and addiction intersection
16. Basic pharmacology - opioid substances
17. Basic pharmacology - non-opioid substances
18. Types of addiction
a. Opioids
b. alcohol
c. tobacco
d. food
e. non-opioid prescription drugs
f. cocaine
g. amphetamines
h. gambling and gaming disorders
i. behavioral addition (compulsive behaviors)
19. Substance use
a. measuring signs and symptoms,
b. conducting screening and monitoring
20. Special study populations
a. elderly,
b. pediatrics
c. pregnancy
d. healthcare professionals
Investigative Therapeutics: Designing studies and measuring outcomes
21. General therapy strategies in substance addiction
a. recovery groups
b. relaxations techniques
c. opioid-sparing drugs
d. weaning controlled substances
e. withdrawal treatment
22. Alternative Therapy Strategies in Addiction
a. acupuncture
b. neurostimulation
c. hypnosis
23. Drug testing and adherence monitoring
24. Pharmacogenetics - Genes, genetics, genomics and epigenetics
a. animal studies
b. human investigations
25. Novel therapeutic strategies effectiveness
a. Medically supervised withdrawal for opioid dependence
b. buprenorphine/methadone
26. Methods of psychosocial interventions
a. Psychodynamic therapy
b. Cognitive-behavioral therapy
c. Interpersonal psychotherapy
d. Problem solving therapy
e. Community-based treatment
27. Principles of vaccine development
28. Drug policy analysis
a. alcohol and drug treatment policy in public health
b. policy frameworks and special legislative provisions
c. criminal justice system and substance use disorders
29. Implementation science: Theories, models and frameworks
30. Designing and testing population-based prevention programs
a. measuring effectiveness
b. analysing availability and coverage of prevention services
c. prevention services in special populations and harm reduction
d. screening and brief intervention programs
e. groups and agencies involved in prevention programs
31. New vistas in research:
a. ultrarapid detoxification
b. other novel strategies
Product details
- No. of pages: 446
- Language: English
- Copyright: © Academic Press 2023
- Published: February 10, 2023
- Imprint: Academic Press
- Paperback ISBN: 9780323988148
- eBook ISBN: 9780323986274
About the Editors
Alan Kaye
Alan David Kaye, MD, PhD, is the Professor and Chairman of the Department of Anesthesiology at LSU Health Sciences Center in New Orleans since January 2005. He is Board Certified as a Consultant in Anesthesiology and has a special certificate in Pain Management for the American Board of Anesthesiology. He is also a Diplomate of the American Board of Pain Medicine and the American Board of Interventional Pain Physicians. His PhD is in pharmacology, and he was awarded first place in the National Student Research Forum as a resident. He has authored or co-authored over 150 abstracts and 200 manuscripts and book chapters in the fields of pulmonary vascular pharmacology and anesthesiology. He serves on a number of national committees including as a National Board of Directors of ASIPP and ABIPP. He is editor-in-chief of the journal Pain Physicians and is on the FDA Advisory Board on Anesthetics and Analgesics.
Affiliations and Expertise
Department of Anesthesiology, School of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Department of Pharmacology, Toxicology, and Neuroscience, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Louisiana Addiction Research Center, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Departments of Anesthesiology and Pharmacology, School of Medicine, Louisiana State University Health Sciences Center at New Orleans, New Orleans, LA, United States;
Departments of Anesthesiology and Pharmacology, Tulane School of Medicine, New Orleans, LA, United States
Richard Urman
Richard D. Urman, MD, MBA, FASA is a staff anesthesiologist at the Brigham and Women’s Hospital in Boston, MA and Associate Professor of Anesthesia at Harvard Medical School. He currently serves as Associate Chair for Dana-Farber Cancer Institute, as well as Medical Director of Sedation for Interventional Medicine, Director, Center for Perioperative Research (C.P.R.), and Perioperative Medicine Fellowship Director. He is also the founder of the Incubator for Patient Safety and Outcomes (IPSO).
Dr. Urman received his MD from Harvard Medical School and MBA from Harvard Business School, and completed a residency in anesthesia at Beth Israel Deaconess Medical Center. On the national level, Dr. Urman currently serves on various committees of the American Society of Anesthesiologists (ASA) including as Chair of the subcommittee on Patient Safety and Practice Management, Foundation of Anesthesia Education and Research (FAER), Society for Preoperative Assessment and Quality Improvement, and Enhanced Recovery After Surgery-USA.
Affiliations and Expertise
Associate Chair for Dana-Farber Cancer Institute; Associate Professor and Director of the Perioperative Medicine Fellowship in the Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Elyse Cornett
Affiliations and Expertise
Department of Anesthesiology, School of Medicine, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Department of Pharmacology, Toxicology & Neuroscience, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Louisiana Addiction Research Center, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, United States;
Department of Anesthesiology, School of Medicine, Louisiana State University Health Sciences Center at New Orleans, New Orleans, LA, United States
Amber Edinoff
Affiliations and Expertise
Harvard Medical School, Massachusetts General Hospital, Department of Psychiatry, Boston, MA, United States
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