Substance Abuse and Addiction Research

Substance Abuse and Addiction Research

Methodology, Mechanisms, and Therapeutics

1st Edition - January 1, 2023

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  • Editors: Alan Kaye, Richard Urman
  • Paperback ISBN: 9780323988148

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Substance Abuse and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on the research methodology for substance abuse and addiction intended for researchers and consumers of research information at all levels. The book is divided into 4 major sections: Introduction; Research Methodology for clinical trials, animal research and retrospective studies; Mechanisms of Abuse and Addiction; and Investigative Therapeutics: Designing and Measuring Outcomes. It serves a source that addresses all aspects of research design, methods and analysis within the context of the field of opioids, alcohol and other substances.The book discusses in detail the research methods used in designing prevention, screening, pharmacological management and health services needed for substance abuse and addiction of all major illicit and prescribed drugs, foods, alcohol, and tobacco products. Research design and useful tips are provided for researchers and consumers of the literature, describing various biological models, specialist and analytical methods. The background on the development of the discipline in question, its key features and applications, how the methods compare to other methods/analyses and their advantages and limitations.The book covers what is known in the field of quantitative and qualitative research methods, provide future directions and introduce new models for investigation. It is organized around a translational science framework, and the contents addresses substance use/addiction research in the context of epidemiology, etiology, intervention efficacy and effectiveness, and implementation of evidence-informed interventions. Most chapters will also include specific examples/case studies so that the reader can apply the knowledge to formulating a plan to solve an actual research question.With a focus on translational science, a discussion of specific drugs that are commonly abused is included, such as opioids, club drugs, cocaine, marijuana, amphetamines, alcohol, and tobacco. The study of both conventional and nonconventional techniques is described, including psychotherapy. The expansion of non-pharmacological therapies such as hypnosis, music therapy, relaxation, hypnosis, and transcutaneous nerve stimulation will also be described.This practical guide on substance use/addiction research will be of value to experienced researchers as well as those new to the field. It will explore various approaches to study design in animal and human models, participant recruitment and retention, measurement and analysis, and the processes involved in the dissemination, diffusion, and implementation of evidence-informed innovations. Above all, the book has plenty of references and existing technical resources and measurement tools that the reader can utilize in their work.

Key Features

  • Practical, easy to read text designed to appeal to both experienced and beginner researchers in the field of substance abuse/addiction science
  • A concise, well-organized handbook, which is a complete guide to methodology in conducting substance abuse/addiction research
  • Contributors include experts from leading academic institutions
  • Ample diagrams, tables and figures to help organize the information for easy reference, along with a list and explanation of existing useful measurement tools, websites, statistical methods, and other resources
  • Sample case studies and proposed approaches to solidify knowledge and demonstrate real-life research problems; both animal and human study designs and methods are discussed


All researchers and clinician-scientists in the field of addiction science and substance abuse, including addiction counsellors, psychiatrists, psychologists, addiction medicine physicians, interventionalists, pain management specialists, and substance abuse social workers, intended for both seasoned researchers and clinicians as well as students and trainees at all levels undergraduate, graduate, post-graduate

Table of Contents

  • Basics of Research Methodology
    1. Reliability and validity in substance abuse and addiction research
    2. Animal models
    a. animal behavior principles
    b. animal drug self-administration
    c. drug discrimination
    d. other topics in animal research
    3. Translational research strategies
    a. human drug administration
    b. measuring drug effects
    4. Experimental design in clinical trials Part 1
    a. definitions, design, intervention
    b. comparison conditions
    5. Experimental design in clinical trials Part 2
    a. target population and recruitment;
    b. sample size; outcome measures
    c. statistical analysis;
    d. scales in addiction;
    e. modes of data collection (e.g., surveys, interviews)
    6. Qualitative and quantitative methods
    a. theory
    b. collecting and organizing data
    7. Ethical issues in opioids, alcohol, other drugs and addiction-related research:
    a. general ethical frameworks
    b. addiction-specific ethical issues
    c. ethics in other countries
    d. funding related ethical issues influence research
    8. Informatics
    a. strategies through infrastructure
    b. general concepts
    9. Artificial intelligence and machine learning
    10. Epidemiology and health services research methods
    a. data acquisition
    b. data analysis
    11. Imaging
    a. techniques
    b. analysis
    12. Systematic review and meta-analysis
    Mechanisms of abuse and addiction
    13. Abuse and addiction
    a. definitions
    b. demographics
    c. general concepts
    14. Assessment of addiction/pain and neurobiology
    15. Physiological considerations in opioid addiction
    a. normal physiology and anatomy
    b. pathophysiological considerations
    c. pain and addiction intersection
    16. Basic pharmacology - opioid substances
    17. Basic pharmacology - non-opioid substances
    18. Types of addiction
    a. Opioids
    b. alcohol
    c. tobacco
    d. food
    e. non-opioid prescription drugs
    f. cocaine
    g. amphetamines
    h. gambling and gaming disorders
    i. behavioral addition (compulsive behaviors)
    19. Substance use
    a. measuring signs and symptoms,
    b. conducting screening and monitoring
    20. Special study populations
    a. elderly,
    b. pediatrics
    c. pregnancy
    d. healthcare professionals
    Investigative Therapeutics: Designing studies and measuring outcomes
    21. General therapy strategies in substance addiction
    a. recovery groups
    b. relaxations techniques
    c. opioid-sparing drugs
    d. weaning controlled substances
    e. withdrawal treatment
    22. Alternative Therapy Strategies in Addiction
    a. acupuncture
    b. neurostimulation
    c. hypnosis
    23. Drug testing and adherence monitoring
    24. Pharmacogenetics - Genes, genetics, genomics and epigenetics
    a. animal studies
    b. human investigations
    25. Novel therapeutic strategies effectiveness
    a. Medically supervised withdrawal for opioid dependence
    b. buprenorphine/methadone
    26. Methods of psychosocial interventions
    a. Psychodynamic therapy
    b. Cognitive-behavioral therapy
    c. Interpersonal psychotherapy
    d. Problem solving therapy
    e. Community-based treatment
    27. Principles of vaccine development
    28. Drug policy analysis
    a. alcohol and drug treatment policy in public health
    b. policy frameworks and special legislative provisions
    c. criminal justice system and substance use disorders
    29. Implementation science: Theories, models and frameworks
    30. Designing and testing population-based prevention programs
    a. measuring effectiveness
    b. analysing availability and coverage of prevention services
    c. prevention services in special populations and harm reduction
    d. screening and brief intervention programs
    e. groups and agencies involved in prevention programs
    31. New vistas in research:
    a. ultrarapid detoxification
    b. other novel strategies

Product details

  • No. of pages: 500
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: January 1, 2023
  • Imprint: Academic Press
  • Paperback ISBN: 9780323988148

About the Editors

Alan Kaye

Richard Urman

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