Studies in Natural Products Chemistry, Volume 38

1st Edition

Editors: Atta-ur- Rahman
Hardcover ISBN: 9780444595300
eBook ISBN: 9780444595386
Imprint: Elsevier
Published Date: 3rd September 2012
Page Count: 544
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Table of Contents



Studies in Natural Products Chemistry edited by Atta-ur-Rahman

Chapter 1 Phytoestrogens: “Estrogene-Like” Phytochemicals



Absorption and Bioavailability of Phytoestrogens

Phytoestrogens “Estrogen-Like” Activities

Health and Phytoestrogens

Dietary Supplements

Safety Aspects


Chapter 2 The Discovery and Synthesis of Brevisamide


Total Syntheses of Brevisamide

Formal Total Syntheses of Brevisamide

Biosynthesis of Brevisamide


Chapter 3 Recent Asymmetric Syntheses of Tetrahydroisoquinolines Using “Named” and Some Other Newer Methods

Asymmetric Bischler–Napieralski Cyclization–Reduction Syntheses

Asymmetric Pomeranz–Fritsch and Related Reactions

Asymmetric Pictet–Spengler Syntheses

Metal-Catalyzed Cyclizations


Chapter 4 1-Methoxy-Canthin-6-One and Related β-Carbolines: From Natural Compound to Synthesis and Biological Activities


1-Methoxy-Canthin-6-One: Extraction from Natural Source

1-Methoxy-Canthin-6-One: Synthetic Procedures

Biological Properties of 1-Methoxy-Canthin-6-One and Related β-Carbolines


Chapter 5 Fern Acylphloroglucinols: Structure, Location, and Biological Effects


Structural Features of Fern Acylphloroglucinols

Acylphloroglucinols from Dryopteris and Related Genera


Dimers and Polymers

Terpenylated Acylphloroglucinols

Elaphoglossum Acylphloroglucinols

Phytochemical and Botanical Considerations

Improvement of Detection and Isolation Procedures

Final Remarks

Chapter 6 Mitogen-Activated Protein Kinase and Natural Phenolic Compounds in Cardiovascular Remodeling


Cardiac Remod


Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate, and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products.

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • A valuable resource for natural product and medicinal chemistry


Natural product chemists, medicinal chemists, pharmacologists as well as researchers, particularly those in academia and in the pharmaceutical industry


No. of pages:
© Elsevier 2012
eBook ISBN:
Hardcover ISBN:


"There is a good mix of chemistry, structure elucidation, synthesis, and biology in the various chapters, thereby appealing to a diverse readership. The diagrams are clear and the writing excellent. In summary, this is another excellent volume in a very valuable series on natural products for which Professor Atta-ur-Rahman is to be congratulated...... an important and essential asset for those libraries supporting the efforts of natural product research groups." --Geoffrey A. Cordell, University of Illinois, Chicago, USA, PHYTOCHEMISTRY, Vol.65, 2004

About the Editors

Atta-ur- Rahman Editor

Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan. Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions. He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003–06), and was again elected President of Pakistan Academy of Sciences in January 2011. He was the Federal Minister for Science and Technology (14 March 2000 – 20 November 2002), Federal M

Affiliations and Expertise

University of Karachi, Pakistan