Description

Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate, and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products.

"There is a good mix of chemistry, structure elucidation, synthesis, and biology in the various chapters, thereby appealing to a diverse readership. The diagrams are clear and the writing excellent. In summary, this is another excellent volume in a very valuable series on natural products for which Professor Atta-ur-Rahman is to be congratulated...... an important and essential asset for those libraries supporting the efforts of natural product research groups."

Geoffrey A. Cordell, University of Illinois, Chicago, USA, PHYTOCHEMISTRY, Vol.65, 2004

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • A valuable resource for natural product and medicinal chemistry
  • Readership

    Natural product chemists, medicinal chemists, pharmacologists as well as researchers, particularly those in academia and in the pharmaceutical industry

    Table of Contents

    Contributors

    Preface

    Studies in Natural Products Chemistry edited by Atta-ur-Rahman

    Chapter 1 Phytoestrogens: “Estrogene-Like” Phytochemicals

    Introduction

    Phytoestrogens

    Absorption and Bioavailability of Phytoestrogens

    Phytoestrogens “Estrogen-Like” Activities

    Health and Phytoestrogens

    Dietary Supplements

    Safety Aspects

    Conclusion

    Chapter 2 The Discovery and Synthesis of Brevisamide

    Introduction

    Total Syntheses of Brevisamide

    Formal Total Syntheses of Brevisamide

    Biosynthesis of Brevisamide

    Summary

    Chapter 3 Recent Asymmetric Syntheses of Tetrahydroisoquinolines Using “Named” and Some Other Newer Methods

    Asymmetric Bischler–Napieralski Cyclization–Reduction Syntheses

    Asymmetric Pomeranz–Fritsch and Related Reactions

    Asymmetric Pictet–Spengler Syntheses

    Metal-Catalyzed Cyclizations

    Conclusions

    Chapter 4 1-Methoxy-Canthin-6-One and Related β-Carbolines: From Natural Compound to Synthesis and Biological Activities

    Introduction

    1-Methoxy-Canthin-6-One: Extraction from Natural Source

    1-Methoxy-Canthin-6-One: Synthetic Procedures

    Biological Properties of 1-Methoxy-Canthin-6-One and Related β-Carbolines

    Conclusion

    Chapter 5 Fern Acylphloroglucinols: Structure, Location, and Biological Effects

    Introduction

    Structural Features of Fern Acylphloroglucinols

    Acylphloroglucinols from Dryopteris and Related Genera

    Monomers

    Dimers and Polymers

    Terpenylated Acylphloroglucinols

    Elaphoglossum Acylphloroglucinols

    Phytochemical and Botanical Considerations

    Improvement of Detection and Isolation Procedures

    Final Remarks

    Chapter 6 Mitogen-Activated Protein Kinase and Natural Phenolic Compounds in Cardiovascular Remodeling

    Introduction

    Cardiac Remod

    Details

    No. of pages:
    544
    Language:
    English
    Copyright:
    © 2012
    Published:
    Imprint:
    Elsevier
    Print ISBN:
    9780444595300
    Electronic ISBN:
    9780444595386

    About the editor

    Atta-ur- Rahman

    Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan. Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions. He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003–06), and was again elected President of Pakistan Academy of Sciences in January 2011. He was the Federal Minister for Science and Technology (14 March 2000 – 20 November 2002), Federal M

    Affiliations and Expertise

    University of Karachi, Pakistan