Description

Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up to the pharmaceutical industry exciting opportunities in the field of new drug development. The series covers all of the above as well as the synthesis, testing and recording of the medicinal properties of natural products.

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • A valuable source for researchers in natural product and medicinal chemistry

Readership

Natural product chemists, medicinal chemists, pharmacologists as well as researchers particularly those in academia and in the pharmaceutical industry

Table of Contents

Contributors

Preface

Chapter 1. Bioprospecting in the Berkeley Pit: The Use of Signal Transduction Enzyme Inhibition Assays to Isolate Bioactive Secondary Metabolites from the Extremophilic Fungi of an Acid Mine Waste Lake

Abbreviations

Introduction

Bioprospecting in an EPA Superfund Site

Use of Signal Transduction Enzymes in Drug Discovery

Isolation of Secondary Metabolites

The Induced Inflammasome Assay

Conclusions

Acknowledgments

References

Chapter 2. Natural and Synthetic Chalcones: Tools for the Study of Targets of Action—Insulin Secretagogue or Insulin Mimetic?

Abbreviations

Introduction

Acknowledgments

References

Chapter 3. Natural Matrix Metalloproteinase Inhibitors: Leads from Herbal Resources

Abbreviations

Introduction

Discussion and Conclusion

Acknowledgments

References

Chapter 4. Materials Science and Engineering of Mucin: A New Aspect of Mucin Chemistry

Abbreviations

Introduction

Mucins in Humans and Other Mammals

Physicochemical Investigations on Mucins

Mucin Chemistry

Structural Aspects of Mucin

Glycoforms of Mucin

Roadmap of Mucin Chemistry

Artificial Mucins

Jellyfish Mucin

Conclusion

References

Chapter 5. Recent Advances in the Synthetic Studies of Pestalotiopsin A and Related Caryophyllene-Type Sesquiterpenoids

Abbreviations

Introduction

Synthetic Studies of Pestalotiopsin A Reported by the Procter Group

Synthetic Studies of Pestalotiopsin A Reported by the Paquette Group

Total Synthesis of Both Enantiomers of Pestalotiopsin A Completed by the Tadano Group

Biological Activities of Pestalotiopsin A and Related Compounds

Acknowledgments

References

Chapter 6. Emerging Targets in the Bioact

Details

No. of pages:
504
Language:
English
Copyright:
© 2013
Published:
Imprint:
Elsevier
eBook ISBN:
9780444626097
Print ISBN:
9780444626158