Studies in Natural Products Chemistry

Studies in Natural Products Chemistry

1st Edition - July 30, 2012

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  • Editor: Atta-ur- Rahman
  • eBook ISBN: 9780444595157

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Description

Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 37 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable source for researchers and engineers working in natural products and medicinal chemistry.

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • A valuable source for researchers and engineers working in natural product and medicinal chemistry

Readership

Natural product chemists, medicinal chemists, pharmacologists as well as researchers in academia and the pharmaceutical industry

Table of Contents

  • Contributors

    Preface

    Studies in Natural Products Chemistry

    Chapter 1 Botanical Medicines for Diuresis

    Introduction

    Methods

    Findings

    Discussion

    Conclusion

    Chapter 2 The Artemisia L. Genus

    Introduction

    Ethnopharmacological Uses of Artemisia Species

    Sesquiterpene Lactones from Artemisia Genus

    Pharmacological Activity of Artemisia Genus

    Anti-inflammatory and Immunosuppressive Activities

    Antitumour Activity

    Abbreviations

    Chapter 3 Secondary Metabolites with Antinematodal Activity from Higher Plants

    Introduction

    Aliphatics

    Polyacetylenes

    Polythiophenes

    Furans and Tetrahydrofurans

    Terpenoids

    Quassinoids

    Steroids

    Phenols and Phenolic Acids

    Phenylpropanoids and Lignans

    Flavonoids

    Coumarins

    Lactones

    Alkaloids

    Isothiocyanates and Glucosinolates

    Cyanogenic Glycosides

    Other Compounds

    Concluding Remarks

    Chapter 4 Beneficial Health Effects of Bioactive Compounds Present in Spices and Aromatic Herbs

    Introduction

    Monoterpenes

    Phenolics Acids

    Flavonoids

    Conclusions

    Chapter 5 Bioactive Plant Isoprenoids

    Overview of Terpenoids

    Menthol (Monoterpene)

    Artemisinin (Sesquiterpene)

    Taxol (Diterpene)

    Ginsenosides (triterpenes)

    Carotenoids (Tetraterpenes)

    Abbreviations

    Chapter 6 Trypanocidal Monoterpenes

    Introduction

    Structure–Activity Relationships for Trypanocidal Monoterpenes

    Conclusion

    Abbreviations

    Chapter 7 Plant and Fungi 3,4-Dihydroisocoumarins

    Introduction

    Plants

    Fungi

    Marine Source

    Pharmacological and Biological Activity

    DHIC from Animal Origin

    Chapter 8 The Modern Analytical Determination of Botanicals and Similar Novel Natural Products by the HPTLC Fingerprint Approach

    Introduction

    The HPTLC World

    Case Studies

    Conclusions

    Chapter 9 Natural Antioxidants (NAO) of Plants Acting as Scavengers of Free Radicals

    Introduction

    Oxidative Damage due to Photochemical Reaction: Formation of Singlet Oxygen (1O2)

    Oxidative Damage due to Non-photochemical Reaction: Formation of Free Radicals and ROS

    Antioxidants

    ROS and Free Radicals

    Cellular Antioxidant Enzyme Systems

    Natural Antioxidants (NAO) of Plants

    Conclusion

    Chapter 10 Bioactive Natural Products as Potential Candidates to Control Aedes aegypti, the Vector of Dengue

    Introduction

    Natural Insecticides Derived from Plants

    Natural Insecticides Derived from Fungi

    Natural Insecticides Derived from Bacteria

    Natural Insecticides Derived from Other Organisms

    Biocontrol Agents

    Bioassay Against Aedes aegypti Larvae

    Conclusions

    Abbreviations

    Subject Index

Product details

  • No. of pages: 438
  • Language: English
  • Copyright: © Elsevier 2012
  • Published: July 30, 2012
  • Imprint: Elsevier
  • eBook ISBN: 9780444595157

About the Editor

Atta-ur- Rahman

Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan.

Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions.

He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003–06), and was again elected President of Pakistan Academy of Sciences in January 2011.

He was the Federal Minister for Science and Technology (14 March 2000 – 20 November 2002), Federal Minister of Education (2002) and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. The Austrian government also honoured him with its highest civil award ("Das Große Goldene Ehrenzeichen am Bande", 2007) in recognition of his eminent contributions.

Prof. Atta-ur-Rahman was the Coordinator General of COMSTECH, an OIC Ministerial Committee comprising the 57 Ministers of Science & Technology from 57 OIC member countries during 1996-2012. He is also the Patron of International Centre of Chemical and Biological Sciences (which comprises a number of institutes, including the Hussain Ebrahim Jamal Research Institute of Chemistry and the Dr. Panjwani Center of Molecular Medicine and Drug Development) at Karachi University.

He established a research center on Genomics in Karachi University. In recognition of the eminent contributions of Prof. Atta-ur-Rahman, a number of institutions have been named after him within and outside Pakistan. These include a natural product chemistry institute (Atta-ur-Rahman Research Institute of Natural Product Discovery, RiND) at the University of Technology Mara in Malaysia, Atta-ur-Rahman School of Applied Biosciences at National University of Science & Technology in Islamabad, and Dr. Atta-ur-Rahman Building at the International Centre for Chemical and Biological Sciences, University of Karachi. The Academy of Sciences in the Developing World (TWAS) based in Trieste, Italy has introduced a Dr. Atta-ur-Rahman Prize in Chemistry to a scientist from the developing world each year. The Prize carries a cash award of $ 5,000 and a Certificate.

Affiliations and Expertise

University of Karachi, Pakistan

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