Studies in Natural Products Chemistry
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Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Studies in Natural Products Chemistry covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.
Key Features
- Focuses on the chemistry of bioactive natural products
- Contains contributions by leading authorities in the field
- Presents sources of new pharmacophores
Readership
Natural product chemists working in academia and industry. Medicinal chemists and pharmacologists in academia and industry
Table of Contents
- Cover
- Title page
- Table of Contents
- Copyright
- Contributors
- Preface
- Chapter 1: Recent advances of the stereoselective bimodal glycosylations for the synthesis of various glucans
- Abstracts
- Introduction
- Bimodal approach toward d-glucan synthesis using 2-O-TAB group
- Application of 2-O-TAB group toward stereoselective mannosylation
- Synthesis of various d-glucan using 2-O-TAB approach
- Acknowledgment
- References
- Chapter 2: Plant-derived diterpenes for breast cancer treatment: New perspectives and recent advances
- Abstract
- Introduction
- Identification of new diterpenes with anti-breast cancer activity
- Diterpenes with antiproliferative activity
- Inhibition of tumor angiogenesis and metastasis by diterpenes
- Induction of cell death mechanisms by diterpenes
- Diterpenes as a therapeutic option in drug-resistant cell lineages
- Nanotechnology as an enhancer of diterpene activity
- Sites of interaction and structure–activity relationship
- Conclusion
- References
- Chapter 3: Flavonoids and anticancer activity: Structure–activity relationship
- Abstract
- Introduction
- General aspects of flavonoids
- Classification of flavonoids
- Overview of SAR studies of flavonoids
- The role of epigenetic modifications in SAR studies
- Multidrug residence (MDR) and SAR
- Recent three-dimensional quantitative structure–activity relationship (3D-QSAR) studies on flavonoids
- Conclusion
- References
- Chapter 4: Bioactive dihydrophenanthrenes from plants
- Abstract
- Introduction
- Biosynthesis of dihydrophenanthrenes
- Separation and identification of dihydrophenanthrenes
- Structural types
- Biological activities
- Conclusions
- References
- Chapter 5: Metabolomics applied to the discovery of new bioactive pharmaceuticals in complex matrices
- Abstract
- Introduction
- Analytical challenges on complex mixtures
- Analytical methods
- Bioinformatic tools
- Biological models
- Conclusion
- Acknowledgment
- References
- Chapter 6: Biosynthesis of polyunsaturated fatty acids by metabolic engineering of yeast Yarrowia lipolytica
- Abstract
- Introduction
- Genetic engineering strategy inducing PUFA production
- Biosynthesis of microbial PUFAs
- Biosynthesis of lipids in modified Yarrowia lipolytica
- Enhanced PUFA production using different carbon sources
- Pilot—Scale process for microbial PUFA production
- Engineering Y. lipolytica for production of lipid compounds other than PUFAs
- Engineering Y. lipolytica for biodiesel production
- Conclusion
- Acknowledgment
- References
- Chapter 7: Aspergillus versicolor as a source of diversified metabolic products with pharmacological activities
- Abstract
- Introduction
- Isolation of secondary metabolites
- Conclusion
- References
- Chapter 8: Antihyperuricemic peptides: A review focused on xanthine oxidase inhibitory activities
- Abstract
- Introduction
- Preparation and properties of antihyperuricemic peptides
- The interactions between XOD and antihyperuricemic peptides
- Conclusion and perspectives
- References
- Chapter 9: Novel cold process applications for the preservation of bioactive components of several natural functional foods
- Abstract
- Introduction
- General considerations about novel LTHV-assisted fluidized bed drying
- Conclusion
- References
- Chapter 10: Advances in biological activities of essential oils
- Abstract
- Introduction
- Encapsulation of essential oils
- Interactions of essential oils
- ACE-inhibitory activities of essential oils
- α-Amylase and α-glucosidase inhibitory activities of essential oils
- Xanthine oxidase inhibitory activities of essential oils
- Conclusions
- References
- Chapter 11: Natural polymers for wound dressing applications
- Abstract
- Introduction
- Commonly used polymers and elements in fabrication of wound dressings
- Novel strategies in fabrication of wound dressings
- Commercial wound dressings by natural polymers
- Conclusions and future outlook
- References
- Chapter 12: Insight into coronaviruses and natural products-based approach for COVID-19 treatment
- Abstract
- Introduction
- Coronavirus
- Potential therapeutic targets for COVID-19 treatment
- Anticoronaviral natural products
- Molecular docking and pharmacokinetic study: For support
- Conclusion
- References
- Index
Product details
- No. of pages: 498
- Language: English
- Copyright: © Elsevier 2022
- Published: July 19, 2022
- Imprint: Elsevier
- Hardcover ISBN: 9780323910996
- eBook ISBN: 9780323911009
About the Editor
Atta-ur Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.
Affiliations and Expertise
Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan
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