Studies in Natural Products Chemistry

Studies in Natural Products Chemistry

Stereoselective Synthesis

1st Edition - March 3, 1993

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  • Editor: Atta-ur-Rahman
  • eBook ISBN: 9781483193243
  • Hardcover ISBN: 9780444893666

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Description

Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins; two-stage coupling process of macrolide antibiotics synthesis; and synthesis of the rifamycin S ansa-chain compound. The complete synthesis of erythromycin A is also covered. The role of isocyanides in the synthesis of beta lactam antibiotics and the characteristics of the beta lactam antibiotics are discussed. The development of an A-Ring annulation strategy for taxane synthesis is also presented. A chapter is devoted to the advances in the synthesis of tumor-promoting diterpenes. The book can provide useful information to chemists, biologists, students, and researchers.

Table of Contents


  • Preface

    Foreword

    Contributors

    Synthetic Routes to the Oxahydrindene Subunit of the Avermectinmilbemycin Family of Antiparasitic Agents: A Review

    A New Tandem Process and its Application to the Syntheses of Macrolide Antibiotics

    Stereoselective Synthetic and Mechanistic Chemistry of Bicyclomycin

    The Role of Isocyanides in the Synthesis of β-Lactam Antibiotics and Related Compounds

    Synthesis of the 1β-Methylcarbapenem Key Intermediates

    Chemical Studies of the Taxane Diterpenes

    Recent Advances in the Synthesis of Tumor-Promoting Diterpenes

    Hydroxylated Indolizidines and Their Synthesis

    A Survey of Indolo [2,3-a] Carbazole Alkaloids and Related Natural Products

    Synthetic Methodology For 2-Amino Alcohols of Biological Interest

    Stereoselective Synthesis of Natural Products Via Cationic and Radical Intermediates

    Subject Index


Product details

  • No. of pages: 540
  • Language: English
  • Copyright: © Elsevier 1993
  • Published: March 3, 1993
  • Imprint: Elsevier
  • eBook ISBN: 9781483193243
  • Hardcover ISBN: 9780444893666

About the Editor

Atta-ur-Rahman

Atta-ur-Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 930 publications in several fields of organic chemistry.

Affiliations and Expertise

Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan

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