Studies in Natural Products Chemistry - 1st Edition - ISBN: 9780444893666, 9781483193243

Studies in Natural Products Chemistry, Volume 12

1st Edition

Stereoselective Synthesis

Editors: Atta-ur-Rahman
eBook ISBN: 9781483193243
Hardcover ISBN: 9780444893666
Imprint: Elsevier
Published Date: 3rd March 1993
Page Count: 540
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Table of Contents




Synthetic Routes to the Oxahydrindene Subunit of the Avermectinmilbemycin Family of Antiparasitic Agents: A Review

A New Tandem Process and its Application to the Syntheses of Macrolide Antibiotics

Stereoselective Synthetic and Mechanistic Chemistry of Bicyclomycin

The Role of Isocyanides in the Synthesis of β-Lactam Antibiotics and Related Compounds

Synthesis of the 1β-Methylcarbapenem Key Intermediates

Chemical Studies of the Taxane Diterpenes

Recent Advances in the Synthesis of Tumor-Promoting Diterpenes

Hydroxylated Indolizidines and Their Synthesis

A Survey of Indolo [2,3-a] Carbazole Alkaloids and Related Natural Products

Synthetic Methodology For 2-Amino Alcohols of Biological Interest

Stereoselective Synthesis of Natural Products Via Cationic and Radical Intermediates

Subject Index


Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins; two-stage coupling process of macrolide antibiotics synthesis; and synthesis of the rifamycin S ansa-chain compound. The complete synthesis of erythromycin A is also covered. The role of isocyanides in the synthesis of beta lactam antibiotics and the characteristics of the beta lactam antibiotics are discussed. The development of an A-Ring annulation strategy for taxane synthesis is also presented. A chapter is devoted to the advances in the synthesis of tumor-promoting diterpenes.
The book can provide useful information to chemists, biologists, students, and researchers.


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