Studies in Natural Products Chemistry

Studies in Natural Products Chemistry

1st Edition - November 24, 2016

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  • Editor: Atta-ur-Rahman
  • Hardcover ISBN: 9780444639325
  • eBook ISBN: 9780444639387

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Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. This series covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products.

Key Features

  • Focuses on the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • Presents sources of new pharmacophores


Natural product chemists, medicinal chemists, pharmacologists as well as academic and industry researchers

Table of Contents

    • Preface
    • Chapter 1. Potentially Chemopreventive Triterpenoids and Other Secondary Metabolites From Plants and Fungi
      • Introduction
      • EBV-EA Induction Test
      • Two-Stage Carcinogenesis Test on Mouse Skin
      • Plant and Fungal Materials Investigated
      • Inhibitory Effects on TPA-Induced EBV-EA Activation
      • Inhibitory Effects on Mouse Skin Carcinogenesis
      • Chemopreventive Effects of Triterpenoids
      • Chemopreventive Effects of Diterpenoids
      • Chemopreventive Effects of Steroids
      • Chemopreventive Effects of Chalcones
      • Chemopreventive Effects of Flavonoids
      • Chemopreventive Effects of Phloroglucinols
      • Chemopreventive Effects of Other Secondary Metabolic Compounds
      • Chemopreventive Effects of Fatty Acids
      • Toxicity, Side Effects, and Improvement of Bioavailability of Triterpenoids
      • Potential Mechanisms of Chemoprevention
      • Concluding Remarks
      • Abbreviations
    • Chapter 2. Structural Diversity, Natural Sources and Pharmacological Potential of Naturally Occurring A-Seco-Triterpenoids
      • Introduction
      • Isolation and Structure Elucidation
      • Seco-Triterpenoids as Biomarkers
      • Biosynthesis
      • Biological Activity
      • Antitumor Activity
      • Effects of A-seco-triterpenoids on the Immune System
      • Antiviral Activity
      • Antibacterial Activity
      • Other Types of Biological Activity
      • The Main Approaches to Synthesis of A-seco-triterpenoids
      • Conclusion
      • A-Seco-Lanostane Triterpenoids
      • A-Seco-Cycloartane Triterpenoids
      • A-Seco-Dammarane Triterpenoids
      • A-Seco-Tirucallane Triterpenoids
      • Schisandra Nortriterpenoids
      • Other Tetracyclic A-Seco-Triterpenoids
      • A-Seco-Oleanane Triterpenoids
      • A-Seco-Ursane Triterpenoids
      • A-Seco-Friedelane Triterpenoids
      • A-Seco-Lupane Triterpenoids
      • Other Pentacyclic A-Seco-Triterpenoids
      • Other A-Seco-Triterpenoids
      • Abbreviations
    • Chapter 3. Kaurenoic Acid: A Diterpene With a Wide Range of Biological Activities
      • Introduction
      • Biosynthesis of Kaurenoic Acid
      • Pharmacological Effects of Kaurenoic Acid
      • Microbiological and Insecticide Effect of Kaurenoic Acid
      • Platforms to Produce Kaurenoid Compounds
      • Concluding Remarks
      • Abbreviations
    • Chapter 4. Review of Patents Based on Triterpene Glycosides of Sea Cucumbers
      • Introduction
      • Methods of Triterpene Glycoside Isolation
      • Inclusion of Triterpene Glycosides in Functional Food and Other Products
      • Immunostimulatory Means
      • Sea Cucumber Glycosides and Cancer
      • Conclusions
    • Chapter 5. Bioactive Dietary Compounds Regulate Mitochondrial Apoptosis Signaling in Ambivalent Way to Function as Neuroprotective or Antitumor Agents
      • Introduction
      • Mitochondria Regulate Cell Survival and Death
      • Phytochemicals Suppress and Promote MPT in Apoptosis
      • Molecular Mechanism Behind Ambivalent Functions of Phytochemicals
      • Conclusion
      • Abbreviations
    • Chapter 6. Dietary Carotenoids for Reduction of Cancer Risk
      • Introduction
      • Classification, Sources, and Metabolism of Dietary Carotenoids
      • Epidemiologic Studies
      • Oxidative Cleavage Reactions
      • Effect on Cancer Cells In Vitro
      • Reduction of Cancer Development in Animal Models
      • Dietary Interventional Studies With Carotenoids
      • Conclusion Remarks
    • Chapter 7. Dihydrochalcones: Occurrence in the Plant Kingdom, Chemistry and Biological Activities
      • Introduction
      • Occurrence in the Plant Kingdom
      • Chemistry
      • Biological Activities
      • Conclusion
      • Abbreviations
    • Chapter 8. Synthetic Advances in the Indane Natural Product Scaffolds as Drug Candidates: A Review
      • Introduction
      • Synthesis
      • Biological Activities
      • Concluding Remarks
      • Abbreviations
    • Chapter 9. Garcinoic Acid: A Promising Bioactive Natural Product for Better Understanding the Physiological Functions of Tocopherol Metabolites
      • Introduction
      • Garcinia kola
      • Vitamin E
      • Synthesis of Vitamin E Long-Chain Metabolites
      • Bioactivity of Garcinoic Acid, Vitamin E, and Long-Chain Metabolites
      • Conclusions and Perspectives
      • Abbreviations
    • Chapter 10. Antibiotics Derived From Marine Organisms: Their Chemistry and Biological Mode of Action
      • Introduction
      • Sources of Marine Antibiotics
      • Chemistry and Activities of Marine Antibiotics
      • Mode of Action
      • Opinion and Conclusion
    • Index

Product details

  • No. of pages: 552
  • Language: English
  • Copyright: © Elsevier 2016
  • Published: November 24, 2016
  • Imprint: Elsevier
  • Hardcover ISBN: 9780444639325
  • eBook ISBN: 9780444639387

About the Editor


Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 930 publications in several fields of organic chemistry.

Affiliations and Expertise

Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan

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