Studies in Natural Products Chemistry

Studies in Natural Products Chemistry

1st Edition - February 17, 2017

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  • Editor: Atta-ur-Rahman
  • eBook ISBN: 9780444639370
  • Hardcover ISBN: 9780444639318

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Description

Studies in Natural Products Chemistry covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry.

Key Features

  • Focuses on the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • Presents sources of new pharmacophores

Readership

Natural product chemists, medicinal chemists, pharmacologists as well as academic and industry researchers

Table of Contents

  • Chapter 1. Natural Environments for Nanoparticles Synthesis of Metal, Metal Oxides, Core–Shell and Bimetallic Systems

    Introduction

    Key Concepts of Biological Nanosynthesis, State of the Art

    Biosynthesis of NPs by Bacteria

    Biosynthesis of NPs by Fungi

    Biosynthesis of NPs in Plant Extracts

    Core@Shell and Mixed NPs

    Mechanistic Concepts

    Summary

    Terms, Abbreviations, and Acronyms

    Chapter 2. 2-Aminoimidazoles: Synthesis by Ring Transformation Reactions

    Introduction

    Synthesis of Aminoimidazoles From Aminooxazoles

    Synthesis of Fused Aminoimidazoles From Aminooxazoles

    Synthesis of Aminoimidazoles From Other Azoles

    Synthesis of Aminoimidazoles From Imidazopyrimidines

    Synthesis of Aminoimidazoles From Other Heterocycles

    Conclusion

    Chapter 3. Strategies for Total Synthesis of Furanocembranolides and Related Natural Products From Marine Organisms

    Introduction

    Synthesis of Acerosolide

    Synthesis of Bipinnatin J

    Synthesis of Rubifolide

    Synthesis of Deoxypukalide

    Further Synthetic Studies Toward Furanocembranolides

    Furanocembranolid Derivatives and Related Compounds

    Concluding Remarks

    Chapter 4. Phyllobilins: A New Group of Bioactive Compounds

    Introduction

    Catabolism of Chlorophyll Pigments

    The PaO/Phyllobilin Pathway

    Regulation of the PaO/Phyllobilin Route

    Structural Characteristics of the FCCs and DFCCs

    Transport Into Vacuole and Isomerization to NCCs and DNCCs

    Further Linear Chlorophyll Catabolites

    Methods of Analysis of Phyllobilins

    Extraction Procedures From Vegetal Tissues

    Analytical and Semipreparative HPLC Methodologies

    Structural Elucidation and Identification: Nuclear Magnetic Resonance

    Structural Elucidation and Identification: Mass Spectrometry

    Biological Properties of Phyllobilins

    Chlorophyll Metabolism in Animals

    Concluding Remarks

    Abbreviations

    Chapter 5. Artemisinin the Nobel Molecule: From Plant to Patient

    Introduction

    From the Plant: ART Biosynthesis

    To the Patient

    Conclusion

    Abbreviations

    Chapter 6. Bioactive Polyphenols for Diabetes and Inflammation in Psoriasis Disease

    Introduction

    Polyphenols From Forest Resources

    Physiopathology of Diabetes Mellitus

    Impact of Forest Biomass Polyphenols on Type 2 Diabetes Mellitus

    Current Concepts of Psoriasis Pathogenesis

    Natural Treatments for Psoriasis: Role of Forest Biomass Polyphenols

    Research Perspective

    Concluding Remarks

    Abbreviation

    Chapter 7. Nonhalogenated Heterotricyclic Sesquiterpenes From Marine Origin I: Fused Systems

    Introduction

    Fused Heterocyclic Sesquiterpenes

    Conclusion

    Abbreviations

    Chapter 8. Phytochemicals With Antileishmanial Activity: Prospective Drug Targets

    Introduction

    Inhibition of Parasite Proteins as Prospective Drug Targets

    Inhibition of Metabolic Pathway of Parasite as Prospective Drug Targets

    Conclusion

    Abbreviations

    Chapter 9. Parthenolide and Parthenolide-Like Sesquiterpene Lactones as Multiple Targets Drugs: Current Knowledge and New Developments

    Introduction

    New Sources of Parthenolide

    Pharmacology of Parthenolide

    Synergistic Effects to Improving the Chemosensitivity to Parthenolide

    Parthenolide Delivery

    Pharmacology of Parthenolide-Like Sesquiterpene Lactones

    Concluding Remarks

    Abbreviations

    Chapter 10. Alkaloids From Apocynaceae: Origin, Pharmacotherapeutic Properties, and Structure-Activity Studies

    Introduction

    Anticancer Activities of Apocynaceaeous Alkaloids

    Neuroprotective and Psychoactive Activities of Apocynaceaeous Alkaloids

    Biocidal Activities of Apocynaceaeous Alkaloids

    Other Pharmacological Properties of Apocynaceaeous Alkaloids

    Structure Activity Relationships

    Derivatives and Synthetic Analogues

    Concluding Remarks

    Abbreviations

Product details

  • No. of pages: 514
  • Language: English
  • Copyright: © Elsevier 2017
  • Published: February 17, 2017
  • Imprint: Elsevier
  • eBook ISBN: 9780444639370
  • Hardcover ISBN: 9780444639318

About the Editor

Atta-ur-Rahman

Atta-ur-Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 930 publications in several fields of organic chemistry.

Affiliations and Expertise

Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan

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