
Studies in Natural Products Chemistry
Description
Key Features
- Focuses on the chemistry of bioactive natural products
- Contains contributions by leading authorities in the field
- Presents sources of new pharmacophores
Readership
Natural product chemists, medicinal chemists, pharmacologists as well as academic and industry researchers
Table of Contents
Chapter 1: Pharmacology and Structure-Activity Relationship of Natural Products With Psychoactive Effects From Salvia divinorum, Mitragyna speciosa, and Ayahuasca
- Abstract
- Introduction
- Psychoactive Principle and Related Pharmacology of S. divinorum, M. speciosa, and Ayahuasca
- Structure-Activity Relationship of Salvinorin A, Mitragynine, and DMT
Chapter 2: Recent Developments on the Synthesis and Applications of Betulin and Betulinic Acid Derivatives as Therapeutic Agents
- Abstract
- Introduction
- Functionalization at the C28 Position
- Functionalization at the C20 Alkene Site
- Functionalization of the A-Ring
- Functionalization of the E-Ring
- Acknowledgements
Chapter 3: Synthetic Approaches to the Naturally Occurring Anticancer Amaryllidaceae Alkaloids trans-dihydrolycoricidine and trans-dihydronarciclasine
- Abstract
- Introduction
- Synthetic Structure-Activity Studies: Illumination of the Anticancer Amaryllidaceae Pharmacophore
- Summary of Strategies Toward the Total Synthesis of trans-dihydrolycoricidine 3
- Summary of Strategies Toward the Total Synthesis of trans-dihydronarciclasine 6
- Conclusions
Chapter 4: Total Synthesis of Schisandra Nortriterpenoids: History, Progress, and Perspective
- Abstract
- Introduction
- Synthesis of Schisandra Nortriterpenoids
- Concluding Remarks
Chapter 5: Chemical Synthesis of Meridianins and Related Derivatives
- Abstract
- Introduction
- Synthesis of Meridianins
- 2000–2005
- 2006–2010
- 2011–2016
- Conclusion
- Acknowledgments
Chapter 6: Biologically Active Isothiocyanates: Protecting Plants and Healing Humans
- Abstract
- Introduction
- General Synthetic Methods
- Biologically Active ITCs
- Conclusions
- Acknowledgements
Chapter 7: Curcumin, a Multitarget Phytochemical: Challenges and Perspectives
- Abstract
- Introduction
- Curcumin Molecular Features
- Antitumor Activity
- Curcumin Antioxidant Activity
- Curcumin Anti-HIV
- Antifungal Activity
- Curcumin Analogs
- Nanotechnological Approaches to Curcumin Delivery
- Concluding Remarks
Chapter 8: Bioactive Coumarins and Xanthones From Calophyllum Genus and Analysis of Their Druglikeness and Toxicological Properties
- Abstract
- Introduction
- Botanical Background of Calophyllum Genus
- Chemistry of Calophyllum Genus
- Chemoinformatics and Toxicoinformatics in Natural Products and Drug Discovery
- Molecular Properties of Coumarins and Xanthones From Calophyllum Species
- Conclusions
- Acknowledgments
- Appendix
Chapter 9: Structure and Biological Functions of d-Glucans and Their Applications
- Abstract
- Introduction
- Relationship Between Glucan Structure and Immunomodulatory Activity
- Relationship Between Glucan Structure and Antioxidant Activity
- Commercial Glucans: Technology Applications and Health Benefits
- Applications of Glucans in Food Products
- Applications of Glucans in Cosmetics
- Potential Applications of Glucans in the Pharmaceutical and Medical Sectors
- Applications of Glucans in Other Sectors
- Advances and Future Perspectives of Glucans
Chapter 10: Chemistry, Bioactivity, and the Structure-Activity Relationship of Cephalotaxine-Type Alkaloids From Cephalotaxus sp.
- Abstract
- Introduction
- Chemistry
- Bioactivity
- Synthesis
- Concluding Remarks
- Acknowledgments
Chapter 11: Analysis of the Protein Binding Sites for Thiamin and Its Derivatives to Elucidate the Molecular Mechanisms of the Noncoenzyme Action of Thiamin (Vitamin B1)
- Abstract
- Introduction
- Overview of the Naturally Occurring Thiamin Compounds and Their Metabolism
- Pharmacological Forms of Thiamin and Their Target Proteins and Pathways
- Thiamin Antagonists
- Noncanonical Thiamin-Binding Proteins
- Analysis of Protein Binding Sites for Thiamin and Derivatives
- Conclusions
- Acknowledgment
Product details
- No. of pages: 454
- Language: English
- Copyright: © Elsevier 2017
- Published: April 21, 2017
- Imprint: Elsevier
- Hardcover ISBN: 9780444639301
- eBook ISBN: 9780444639363
About the Editor
Atta-ur-Rahman

Affiliations and Expertise
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