Studies in Natural Products Chemistry

Studies in Natural Products Chemistry

1st Edition - May 17, 2022

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  • Editor: Atta-ur-Rahman
  • eBook ISBN: 9780323910989
  • Hardcover ISBN: 9780323910972

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Description

Studies in Natural Products Chemistry, Volume 73 covers the synthesis, testing and recording of medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over millennia through genetic effects. With rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and determine the structures and biological activity of natural products. Hence, these new discoveries have created new avenues and applications for their use.

Key Features

  • Focuses on the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • Presents sources of new pharmacophores

Readership

Natural product chemists working in academia and industry. Medicinal chemists and pharmacologists in academia and industry

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Studies in Natural Products Chemistry
  • Copyright
  • Contributor
  • Preface
  • Chapter 1. Recent advances in pluramycins, biological activity, and synthetic strategies
  • 1. Introduction
  • 2. Biological activities of the pluramycin family
  • 3. Biosynthesis
  • 4. Recent synthetic reports of pluramycins
  • 5. Conclusion
  • Abbreviations
  • Chapter 2. Anticancer naphthoquinone derivatives: an updated patent review (2012–19)
  • 1. Introduction
  • 2. Naphthoquinone patents
  • 3. Conclusion
  • Chapter 3. Recent patents on anticancer potential of sesquiterpene lactones
  • 1. Introduction
  • 2. Sesquiterpene lactones
  • 3. Sesquiterpene lactone nucleus
  • 4. Anticancer properties of sesquiterpene lactones
  • 5. Germacranolides
  • 6. Pseudoguaianolides
  • 7. Guaianolides
  • 8. Eudesmanolide
  • 9. Elemanolides
  • 10. Other sesquiterpenes
  • 11. Conclusion
  • Chapter 4. Resveratrol: a potential drug candidate with multispectrum therapeutic application
  • 1. Introduction
  • 2. SAR of resveratrol and its analogues
  • 3. Biological activities of resveratrol and its derivatives (preclinical and clinical studies)
  • 4. Mechanism of action through which resveratrol exerts its biological effects
  • 5. Side effects
  • 6. Conclusion and future perspectives
  • Abbreviations
  • Chapter 5. Recent developments on bioactivities of mushrooms: structure–activity nexus therapeutic potentials
  • 1. Introduction
  • 2. Methodology
  • 3. Chemistry and bioactive components in mushrooms
  • 4. Reported activities against notable diseases
  • 5. Structure–activity relationship of natural bioactives from mushrooms
  • 6. Results and discussion
  • 7. Conclusion
  • Abbreviations
  • Chapter 6. Coumarin derivatives: biomedicinal properties and interactions with carrier proteins
  • 1. Introduction
  • 2. Carrier proteins: serum albumins
  • 3. Coumarin derivatives: structure and functions
  • 4. Experimental methods to study protein–ligand interactions
  • 5. Binding of coumarins with serum albumins
  • 6. Structure–activity relationship
  • 7. Conclusion
  • Chapter 7. Advances in the green extraction methods and pharmaceutical applications of bioactive pectins from unconventional sources: a review
  • Highlights
  • 1. Introduction
  • 2. Unconventional pectic polysaccharides
  • 3. Unconventional pectin extraction methods
  • 4. Conventional and emerging analytical techniques
  • 5. Structural and chemical modifications of unconventional pectin
  • 6. Applications of unconventional pectins for desirable biological effects
  • 7. Trends and future opportunities
  • 8. Conclusion
  • Abbreviations
  • Chapter 8. Bioactive stilbenes from plants
  • 1. Introduction
  • 2. Structure types
  • 3. Molecular identification of stilbenes
  • 4. Biological activities
  • 5. Conclusion
  • Chapter 9. Curcumin as a privileged scaffold molecule for various biological targets in drug development
  • 1. Introduction
  • 2. Chemistry and SAR of curcumin and its analogs
  • 3. Therapeutic effects of curcumin (preclinical studies in vitro and in vivo)
  • 4. Curcumin in clinical trials
  • 5. Novel delivery strategies employed to overcome bioavailability of curcumin
  • 6. Conclusion
  • Abbreviations
  • Chapter 10. The potential use of agro-industrial by-products as sources of bioactive compounds: a nanotechnological approach
  • 1. Introduction
  • 2. Agro-industrial by-products as food additives
  • 3. Ethanol and fuel production
  • 4. Antibiotic production
  • 5. Feed production
  • 6. Other usages of agro-industrial by-products
  • 7. Applications of agro-industrial wastes in nanotechnology
  • 8. Conclusion
  • Chapter 11. Marine-derived antidiabetic compounds: an insight into their sources, chemistry, SAR, and molecular mechanisms
  • 1. Introduction
  • 2. Marine sources as upcoming antidiabetic agents
  • 3. Marine-derived molecules with target selective activity
  • 4. Chemistry and SAR analysis of some selective marine antidiabetic leads
  • 5. Molecular investigations on diabetic targets
  • 6. Upcoming challenges and future prospects
  • 7. Conclusion
  • Index

Product details

  • No. of pages: 544
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: May 17, 2022
  • Imprint: Elsevier
  • eBook ISBN: 9780323910989
  • Hardcover ISBN: 9780323910972

About the Editor

Atta-ur-Rahman

Atta-ur-Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 930 publications in several fields of organic chemistry.

Affiliations and Expertise

Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan

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