First published on January 1, 1972

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  • Editor: Geoffrey Bourne
  • eBook ISBN: 9780323161800

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The Biochemistry and Physiology of Bone, Second Edition: Volume I: Structure focuses on the nature and behavior of bone cells, the structure of the organic matrix of bone, mineral organization, and bone strength. It explores the histology of bone, the pathological calcification and radiation effects on bone, particularly, the morphology and cytochemistry as well as the functional significance of osteoblasts, the mode of action of the osteoclast, the ultrastructure of bone, and the mechanical engineering problems presented by bone. Organized into nine chapters, this edition begins with an overview of the general histology of bone, including tissues related to bone and its elementary constituents. It then discusses the origin of osteoblasts, the role of the osteoclast in the mechanism whereby calcium is unlocked from the skeleton under the influence of the parathyroid hormone, and the physiological and pathological effects of vitamins and hormones on skeletal tissue in vitro. It also explains the chemical composition of bone and the chemistry of bone collagen, the relationship between bone mineral and the organic matrix, the macromolecular organization of apatite and collagen, and the examinations of bone by scanning electron microscopy. The book concludes with a chapter on the shape, strength, and elasticity of bone. This book is a valuable source of information for anatomists, orthopedists, biochemists, cell biologists, physiologists, biomedical engineers, pathologists, clinicians, graduate students, professors, and others interested in the biochemical and physiological aspects of bone.

Table of Contents

  • List of Contributors

    Preface to Second Edition

    Preface to First Edition

    Contents of Other Volumes

    Chapter 1. General Histology of Bone

    I. Introduction

    II. Tissues Related to Bone

    III. Elementary Constituents of Bone

    IV. The Osteocytes V. Elementary Types of Bone

    VI. Higher Organization of Bone

    VII. Lamellation

    VIII. "Membrane" and "Cartilage" Bone and Bones

    IX. Evolution of Bone and Cartilage


    Chapter 2. The Osteoblast

    I. Introduction

    II. General Morphology

    III. Cytochemistry

    IV. The Functional Significance of Osteoblasts

    V. Origin of Osteoblasts


    Chapter 3. The Osteoclast

    I. Introduction

    II. Appearance

    III. Function

    IV. Mode of Action

    V. The Osteoclast and Parathyroid Hormone

    VI. Origin, Life-span, and Fate


    Chapter 4. Skeletal Tissue in Culture

    I. Introduction

    II. Historical Aspects

    III. Techniques for the Growth of Skeletal Elements in Vitro

    IV. Metabolism of Skeletal Tissue in Vitro

    V. Physiological and Pathological Effects of Vitamins and Hormones on Skeletal Tissue in Vitro

    VI. Effects of Miscellaneous Substances on Skeletal Tissue in Vitro

    VII. Conclusions and Outlook


    Chapter 5. The Organic Matrix of Bone

    I. Introduction

    II. The Chemical Composition of Bone

    III. The Chemistry of Bone Collagen

    IV. The Glycosaminoglycans (Acid Mucopolysaccharides) of Bone

    V. The Glycoproteins of Bone

    VI. The Lipids of Bone

    VII. The Peptides of Bone

    VIII. Molecular Interactions and Function


    Chapter 6. The Ultrastructure of Bone

    I. Introduction

    II. The Organic Matrix of Bone

    III. The Bone Mineral

    IV. The Relationship between Mineral and Matrix

    V. The Bone Cells


    Chapter 7. Aspects of the Molecular Structure of Bone

    I. Introduction

    II. The Inorganic Phase of Bone

    III. Macromolecular Organization of Apatite and Collagen

    IV. Concluding Remarks


    Chapter 8. Scanning Electron Microscope Studies of Bone

    I. Introduction

    II. The Scanning Electron Microscope

    III. Preparation of Bone Specimen for the Scanning Electron Microscope

    IV. Adult Bone

    V. Fetal Bone

    VI. Endochondral Ossification

    VII. Characteristics of Fractured Surfaces

    VIII. Discussion


    Chapter 9. Bone as a Mechanical Engineering Problem

    I. Introduction

    II. Shape and Size

    III. Growth of the Skull

    IV. Cancellous Bone

    V. Bone Strength

    VI. Microstrength of Bone

    VII. Hormonal Effects

    VIII. Nervous Influences on Bone

    IX. Strength of Healing Fractures


    Author Index

    Subject Index

Product details

  • No. of pages: 392
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 1, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9780323161800

About the Editor

Geoffrey Bourne

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